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MX2025000220A - Metodo de conjugacion de cys-acm - Google Patents

Metodo de conjugacion de cys-acm

Info

Publication number
MX2025000220A
MX2025000220A MX2025000220A MX2025000220A MX2025000220A MX 2025000220 A MX2025000220 A MX 2025000220A MX 2025000220 A MX2025000220 A MX 2025000220A MX 2025000220 A MX2025000220 A MX 2025000220A MX 2025000220 A MX2025000220 A MX 2025000220A
Authority
MX
Mexico
Prior art keywords
mabs
cys
conjugation
conjugates
capping
Prior art date
Application number
MX2025000220A
Other languages
English (en)
Inventor
Michal Achmatowicz
Dante ROMANINI
James R Falsey
Bradley J Herberich
Oliver R Thiel
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63371775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2025000220(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2025000220A publication Critical patent/MX2025000220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6859—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from liver or pancreas cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente divulgación se refiere a un método de tapado, reducción y oxidación de cys-AcM con el fin de proporcionar material homogéneo para reacciones de conjugación posteriores. El presente método demuestra modos robustos para fabricar conjugados de cisteína-anticuerpos modificados por ingeniería genética que ofrecen alto rendimiento y calidad del producto constante. En una modalidad específica de la invención, el método comprende utilizar un agente reductor que se selecciona de TCEP y TPPDS y en su etapa de purificación puede incluir cromatografía de interacción hidrófoba ("HIC"), ultrafiltración/diafiltración o cromatografía de interacción hidrófoba ("HIC") seguido por ultrafiltración/diafiltración. En otra modalidad preferida de la invención el agente oxidante es ácido deshidroascórbico ("DHAA").
MX2025000220A 2017-08-04 2020-01-31 Metodo de conjugacion de cys-acm MX2025000220A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541522P 2017-08-04 2017-08-04
PCT/US2018/045212 WO2019028382A1 (en) 2017-08-04 2018-08-03 CYS-MABS CONJUGATION METHOD

Publications (1)

Publication Number Publication Date
MX2025000220A true MX2025000220A (es) 2025-02-10

Family

ID=63371775

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020001327A MX2020001327A (es) 2017-08-04 2018-08-03 Metodo de conjugacion de cys-acm.
MX2025000220A MX2025000220A (es) 2017-08-04 2020-01-31 Metodo de conjugacion de cys-acm

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020001327A MX2020001327A (es) 2017-08-04 2018-08-03 Metodo de conjugacion de cys-acm.

Country Status (19)

Country Link
US (1) US20210346513A1 (es)
EP (2) EP3661562B1 (es)
JP (2) JP7504025B2 (es)
AU (1) AU2018309090B2 (es)
CA (1) CA3071852A1 (es)
DK (1) DK3661562T3 (es)
ES (1) ES2997332T3 (es)
FI (1) FI3661562T3 (es)
HR (1) HRP20241422T1 (es)
HU (1) HUE069142T2 (es)
LT (1) LT3661562T (es)
MA (1) MA68842B1 (es)
MX (2) MX2020001327A (es)
PL (1) PL3661562T3 (es)
PT (1) PT3661562T (es)
RS (1) RS66295B1 (es)
SI (1) SI3661562T1 (es)
SM (1) SMT202400503T1 (es)
WO (1) WO2019028382A1 (es)

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EP3661562B1 (en) * 2017-08-04 2024-10-02 Amgen Inc. Method of conjugation of cys-mabs
WO2025038435A1 (en) * 2023-08-11 2025-02-20 Amgen Inc. Methods of solid phase antibody conjugation
TW202528348A (zh) * 2023-10-31 2025-07-16 大陸商山東博安生物技術股份有限公司 Gipr阻斷型抗體及其抗體偶聯物
WO2025167838A1 (en) * 2024-02-08 2025-08-14 Suzhou Bioreinno Biotechnology Limited Company Antibodies, antibody-drug conjugates, and producing methods thereof
WO2025184315A1 (en) * 2024-02-29 2025-09-04 Amgen Inc. Glucagon receptor agonists, conjugated to glucose-dependent insulinotropic polypeptide antibodies

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Also Published As

Publication number Publication date
CA3071852A1 (en) 2019-02-07
ES2997332T3 (en) 2025-02-17
MX2020001327A (es) 2020-03-20
HUE069142T2 (hu) 2025-02-28
FI3661562T3 (fi) 2024-12-09
MA68842B1 (fr) 2025-01-31
EP3661562B1 (en) 2024-10-02
SMT202400503T1 (it) 2025-01-14
HRP20241422T1 (hr) 2025-01-03
PT3661562T (pt) 2024-12-13
EP4464719A3 (en) 2025-03-05
EP3661562A1 (en) 2020-06-10
AU2018309090B2 (en) 2023-03-30
PL3661562T3 (pl) 2025-02-24
AU2018309090A1 (en) 2020-02-20
SI3661562T1 (sl) 2025-01-31
EP4464719A2 (en) 2024-11-20
RS66295B1 (sr) 2025-01-31
JP2024095687A (ja) 2024-07-10
US20210346513A1 (en) 2021-11-11
LT3661562T (lt) 2024-10-25
DK3661562T3 (da) 2024-12-16
JP7504025B2 (ja) 2024-06-21
WO2019028382A1 (en) 2019-02-07
JP2020529986A (ja) 2020-10-15

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