MX2024006270A - Nueva composicion farmaceutica oral y regimen de dosificacion para la terapia de enfermedades pulmonares intersticiales fibrosantes progresivas. - Google Patents
Nueva composicion farmaceutica oral y regimen de dosificacion para la terapia de enfermedades pulmonares intersticiales fibrosantes progresivas.Info
- Publication number
- MX2024006270A MX2024006270A MX2024006270A MX2024006270A MX2024006270A MX 2024006270 A MX2024006270 A MX 2024006270A MX 2024006270 A MX2024006270 A MX 2024006270A MX 2024006270 A MX2024006270 A MX 2024006270A MX 2024006270 A MX2024006270 A MX 2024006270A
- Authority
- MX
- Mexico
- Prior art keywords
- oral pharmaceutical
- pharmaceutical composition
- interstitial lung
- lung diseases
- therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Una composición farmacéutica oral que consiste esencialmente en el inhibidor de la PDE4B de fórmula III (ver Fórmula) a la dosis de 18 mg o 9 mg y opcionalmente, uno o más vehículos o excipientes farmacéuticamente aceptables para usar en el tratamiento de un paciente que sufre de una o más enfermedades pulmonares intersticiales fibrosantes progresivas (PF-ILD), en donde esta composición farmacéutica oral se administrará al paciente dos veces al día. La invención se refiere además a composiciones farmacéuticas orales que comprenden el inhibidor de la PDE4B de fórmula III a la dosis de 18 mg o 9 mg y una dosis terapéuticamente eficaz de un segundo ingrediente activo seleccionado entre nintedanib o pirfenidona, en donde estas composiciones farmacéuticas orales se administran al paciente dos veces al día.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163287642P | 2021-12-09 | 2021-12-09 | |
| EP21218202 | 2021-12-29 | ||
| EP22177750 | 2022-06-08 | ||
| PCT/EP2022/084968 WO2023104958A1 (en) | 2021-12-09 | 2022-12-08 | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024006270A true MX2024006270A (es) | 2024-06-11 |
Family
ID=84785289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024006270A MX2024006270A (es) | 2021-12-09 | 2022-12-08 | Nueva composicion farmaceutica oral y regimen de dosificacion para la terapia de enfermedades pulmonares intersticiales fibrosantes progresivas. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20230181590A1 (es) |
| EP (2) | EP4494700A3 (es) |
| JP (1) | JP2024543161A (es) |
| KR (2) | KR20240121251A (es) |
| AU (2) | AU2022407131C1 (es) |
| CA (1) | CA3234847A1 (es) |
| CL (2) | CL2024001520A1 (es) |
| DK (1) | DK4426307T3 (es) |
| ES (1) | ES3041145T3 (es) |
| FI (1) | FI4426307T3 (es) |
| HR (1) | HRP20251043T1 (es) |
| HU (1) | HUE073199T2 (es) |
| IL (1) | IL312740A (es) |
| LT (1) | LT4426307T (es) |
| MX (1) | MX2024006270A (es) |
| PL (1) | PL4426307T3 (es) |
| RS (1) | RS67225B1 (es) |
| SI (1) | SI4426307T1 (es) |
| TW (1) | TW202339731A (es) |
| WO (1) | WO2023104958A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4570804A1 (en) * | 2022-08-09 | 2025-06-18 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| CN119857088A (zh) * | 2025-01-22 | 2025-04-22 | 杭州畅溪制药有限公司 | 复方吸入粉雾剂及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004057645A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057595A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057594A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057618A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| CN101163706A (zh) | 2005-04-21 | 2008-04-16 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的二氢噻吩并嘧啶 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| RU2500681C2 (ru) | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| EP2610258B1 (de) | 2007-10-19 | 2014-08-27 | Boehringer Ingelheim International Gmbh | Substituierte Piperidino-Dihydrothienopyrimidine |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| FI3700529T3 (fi) | 2017-10-23 | 2025-09-18 | Boehringer Ingelheim Int | Uusi aktiivisten aineiden yhdistelmä etenevien fibrotisoivien interstitiaalisten keuhkosairauksien (pf-ild) hoitoon |
-
2022
- 2022-12-08 MX MX2024006270A patent/MX2024006270A/es unknown
- 2022-12-08 ES ES22835249T patent/ES3041145T3/es active Active
- 2022-12-08 RS RS20250900A patent/RS67225B1/sr unknown
- 2022-12-08 SI SI202230167T patent/SI4426307T1/sl unknown
- 2022-12-08 DK DK22835249.8T patent/DK4426307T3/da active
- 2022-12-08 LT LTEPPCT/EP2022/084968T patent/LT4426307T/lt unknown
- 2022-12-08 EP EP24218458.8A patent/EP4494700A3/en active Pending
- 2022-12-08 IL IL312740A patent/IL312740A/en unknown
- 2022-12-08 PL PL22835249.8T patent/PL4426307T3/pl unknown
- 2022-12-08 JP JP2024531320A patent/JP2024543161A/ja active Pending
- 2022-12-08 EP EP22835249.8A patent/EP4426307B1/en active Active
- 2022-12-08 WO PCT/EP2022/084968 patent/WO2023104958A1/en not_active Ceased
- 2022-12-08 US US18/063,190 patent/US20230181590A1/en not_active Abandoned
- 2022-12-08 KR KR1020247020831A patent/KR20240121251A/ko active Pending
- 2022-12-08 TW TW111147108A patent/TW202339731A/zh unknown
- 2022-12-08 AU AU2022407131A patent/AU2022407131C1/en active Active
- 2022-12-08 CA CA3234847A patent/CA3234847A1/en active Pending
- 2022-12-08 HU HUE22835249A patent/HUE073199T2/hu unknown
- 2022-12-08 FI FIEP22835249.8T patent/FI4426307T3/fi active
- 2022-12-08 HR HRP20251043TT patent/HRP20251043T1/hr unknown
- 2022-12-08 KR KR1020257040911A patent/KR20260004530A/ko active Pending
-
2024
- 2024-02-23 US US18/585,280 patent/US20250025466A1/en active Pending
- 2024-05-20 CL CL2024001520A patent/CL2024001520A1/es unknown
- 2024-11-26 CL CL2024003616A patent/CL2024003616A1/es unknown
-
2025
- 2025-07-11 AU AU2025205402A patent/AU2025205402A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RS67225B1 (sr) | 2025-10-31 |
| JP2024543161A (ja) | 2024-11-19 |
| AU2025205402A1 (en) | 2025-07-31 |
| AU2022407131B2 (en) | 2025-06-19 |
| US20230181590A1 (en) | 2023-06-15 |
| AU2022407131C1 (en) | 2025-10-30 |
| AU2022407131A1 (en) | 2024-04-11 |
| CL2024003616A1 (es) | 2025-03-21 |
| CA3234847A1 (en) | 2023-06-15 |
| HUE073199T2 (hu) | 2026-01-28 |
| KR20240121251A (ko) | 2024-08-08 |
| SI4426307T1 (sl) | 2025-12-31 |
| ES3041145T3 (en) | 2025-11-07 |
| DK4426307T3 (da) | 2025-09-15 |
| KR20260004530A (ko) | 2026-01-08 |
| TW202339731A (zh) | 2023-10-16 |
| US20250025466A1 (en) | 2025-01-23 |
| EP4494700A2 (en) | 2025-01-22 |
| FI4426307T3 (fi) | 2025-09-10 |
| EP4426307A1 (en) | 2024-09-11 |
| WO2023104958A1 (en) | 2023-06-15 |
| HRP20251043T1 (hr) | 2025-10-24 |
| LT4426307T (lt) | 2025-09-10 |
| EP4426307B1 (en) | 2025-07-02 |
| IL312740A (en) | 2024-07-01 |
| EP4494700A3 (en) | 2025-04-16 |
| PL4426307T3 (pl) | 2025-11-17 |
| CL2024001520A1 (es) | 2024-11-22 |
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