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MX2024003214A - Derivados de idebenona y su uso en el tratamiento de plantas. - Google Patents

Derivados de idebenona y su uso en el tratamiento de plantas.

Info

Publication number
MX2024003214A
MX2024003214A MX2024003214A MX2024003214A MX2024003214A MX 2024003214 A MX2024003214 A MX 2024003214A MX 2024003214 A MX2024003214 A MX 2024003214A MX 2024003214 A MX2024003214 A MX 2024003214A MX 2024003214 A MX2024003214 A MX 2024003214A
Authority
MX
Mexico
Prior art keywords
plant treatment
treatment
idebenone derivatives
formula
idebenone
Prior art date
Application number
MX2024003214A
Other languages
English (en)
Inventor
Mark Wood
Matthew Whiteman
Roberta Torregrossa
Original Assignee
Mitorx Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitorx Therapeutics Ltd filed Critical Mitorx Therapeutics Ltd
Publication of MX2024003214A publication Critical patent/MX2024003214A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La invención se refiere a un compuesto de fórmula (I) (ver formula) que comprende un grupo de dirección mitocondrial unido a un grupo capaz de liberar sulfuro de hidrógeno para uso en el tratamiento del cuerpo humano o animal o de tejidos y células derivados de los mismos y al uso en el tratamiento de plantas y a nuevos compuestos relacionados.
MX2024003214A 2021-09-14 2022-09-14 Derivados de idebenona y su uso en el tratamiento de plantas. MX2024003214A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2113117.2A GB2610815A (en) 2021-09-14 2021-09-14 Compounds
PCT/GB2022/052325 WO2023041906A1 (en) 2021-09-14 2022-09-14 Idebenone derivatives and their use in treating plants

Publications (1)

Publication Number Publication Date
MX2024003214A true MX2024003214A (es) 2024-07-30

Family

ID=78149340

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024003214A MX2024003214A (es) 2021-09-14 2022-09-14 Derivados de idebenona y su uso en el tratamiento de plantas.

Country Status (10)

Country Link
US (1) US20240400536A1 (es)
EP (1) EP4396174A1 (es)
JP (1) JP2024535017A (es)
KR (1) KR20240108380A (es)
CN (1) CN118234716A (es)
AU (1) AU2022347098A1 (es)
CA (1) CA3231394A1 (es)
GB (1) GB2610815A (es)
MX (1) MX2024003214A (es)
WO (1) WO2023041906A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025104452A1 (en) 2023-11-17 2025-05-22 Mitorx Therapeutics Ltd Compounds for use in treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664069B8 (en) * 2003-08-22 2015-07-01 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
US8263094B2 (en) 2008-09-23 2012-09-11 Eastman Chemical Company Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof

Also Published As

Publication number Publication date
CN118234716A (zh) 2024-06-21
GB202113117D0 (en) 2021-10-27
JP2024535017A (ja) 2024-09-26
KR20240108380A (ko) 2024-07-09
EP4396174A1 (en) 2024-07-10
CA3231394A1 (en) 2023-03-23
GB2610815A (en) 2023-03-22
WO2023041906A1 (en) 2023-03-23
US20240400536A1 (en) 2024-12-05
AU2022347098A1 (en) 2024-04-04

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