MX2024001613A - Derivado de oxaspiro, metodo de preparacion del mismo y uso del mismo. - Google Patents
Derivado de oxaspiro, metodo de preparacion del mismo y uso del mismo.Info
- Publication number
- MX2024001613A MX2024001613A MX2024001613A MX2024001613A MX2024001613A MX 2024001613 A MX2024001613 A MX 2024001613A MX 2024001613 A MX2024001613 A MX 2024001613A MX 2024001613 A MX2024001613 A MX 2024001613A MX 2024001613 A MX2024001613 A MX 2024001613A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- method therefor
- oxaspiro
- derivative
- oxaspiro derivative
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un derivado de oxaespiro y a su método de preparación y uso; específicamente, se proporcionan un compuesto representado por la fórmula general (I), un estereoisómero del mismo, un tautómero del mismo o una sal farmacéuticamente aceptable del mismo y un método de preparación del mismo, el uso del mismo para activar la actividad de un receptor opioide, y el uso del mismo en la preparación de un fármaco analgésico. (ver Fórmula).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110888850 | 2021-08-02 | ||
| CN202110895052 | 2021-08-02 | ||
| PCT/CN2022/109503 WO2023011422A1 (zh) | 2021-08-02 | 2022-08-01 | 氧杂螺环类衍生物、制备方法及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024001613A true MX2024001613A (es) | 2024-02-27 |
Family
ID=85154442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024001613A MX2024001613A (es) | 2021-08-02 | 2022-08-01 | Derivado de oxaspiro, metodo de preparacion del mismo y uso del mismo. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240398772A1 (es) |
| EP (1) | EP4375286A4 (es) |
| JP (1) | JP7710599B2 (es) |
| KR (1) | KR20240042486A (es) |
| CN (1) | CN117751126A (es) |
| AU (1) | AU2022322838B2 (es) |
| CA (1) | CA3227380A1 (es) |
| IL (1) | IL310506A (es) |
| MX (1) | MX2024001613A (es) |
| TW (1) | TW202321258A (es) |
| WO (1) | WO2023011422A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1675847B1 (en) | 2003-10-01 | 2012-12-05 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| PL3290415T3 (pl) | 2011-03-23 | 2021-07-19 | Trevena, Inc. | Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania |
| US10442793B2 (en) * | 2015-10-15 | 2019-10-15 | Jiangsu Hengrui Medicine Co., Ltd | Oxa spiro derivative, preparation method therefor, and applications thereof in medicines |
| EP3722283A1 (en) * | 2016-01-13 | 2020-10-14 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CN109206417B (zh) * | 2017-07-04 | 2023-01-03 | 四川海思科制药有限公司 | 阿片受体激动剂及其应用 |
| US11124523B2 (en) | 2017-10-13 | 2021-09-21 | Shandong Luye Pharmaceutical Co., Ltd. | 2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof |
| WO2019205983A1 (zh) * | 2018-04-28 | 2019-10-31 | 四川科伦博泰生物医药股份有限公司 | 氧杂螺环类化合物及其制备方法和用途 |
| EP4092031A4 (en) * | 2020-01-17 | 2024-02-21 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Azabicyclic substituted oxaspiro derivative, preparation method therefor and medical use thereof |
-
2022
- 2022-08-01 TW TW111128749A patent/TW202321258A/zh unknown
- 2022-08-01 US US18/292,775 patent/US20240398772A1/en active Pending
- 2022-08-01 MX MX2024001613A patent/MX2024001613A/es unknown
- 2022-08-01 CA CA3227380A patent/CA3227380A1/en active Pending
- 2022-08-01 IL IL310506A patent/IL310506A/en unknown
- 2022-08-01 CN CN202280052788.3A patent/CN117751126A/zh active Pending
- 2022-08-01 AU AU2022322838A patent/AU2022322838B2/en active Active
- 2022-08-01 KR KR1020247007142A patent/KR20240042486A/ko active Pending
- 2022-08-01 JP JP2024506537A patent/JP7710599B2/ja active Active
- 2022-08-01 EP EP22852134.0A patent/EP4375286A4/en active Pending
- 2022-08-01 WO PCT/CN2022/109503 patent/WO2023011422A1/zh not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022322838A1 (en) | 2024-02-15 |
| TW202321258A (zh) | 2023-06-01 |
| US20240398772A1 (en) | 2024-12-05 |
| CN117751126A (zh) | 2024-03-22 |
| WO2023011422A1 (zh) | 2023-02-09 |
| JP7710599B2 (ja) | 2025-07-18 |
| JP2024528181A (ja) | 2024-07-26 |
| CA3227380A1 (en) | 2023-02-09 |
| KR20240042486A (ko) | 2024-04-02 |
| EP4375286A1 (en) | 2024-05-29 |
| AU2022322838B2 (en) | 2024-12-12 |
| IL310506A (en) | 2024-03-01 |
| EP4375286A4 (en) | 2024-11-27 |
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