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MX2023014444A - Modular la expresion de apolipoproteina (a). - Google Patents

Modular la expresion de apolipoproteina (a).

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Publication number
MX2023014444A
MX2023014444A MX2023014444A MX2023014444A MX2023014444A MX 2023014444 A MX2023014444 A MX 2023014444A MX 2023014444 A MX2023014444 A MX 2023014444A MX 2023014444 A MX2023014444 A MX 2023014444A MX 2023014444 A MX2023014444 A MX 2023014444A
Authority
MX
Mexico
Prior art keywords
apo
disorders
oligomeric compounds
diseases
conditions
Prior art date
Application number
MX2023014444A
Other languages
English (en)
Inventor
Nicholas J Viney
Richard S Geary
Yanfeng Wang
Zhengrong Yu
Rudy Gunawan
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2023014444A publication Critical patent/MX2023014444A/es

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Abstract

En la presente, se proporcionan compuestos oligoméricos con grupos conjugados dirigidos a apolipoproteína (a) [apo(a)]. En determinadas modalidades, los compuestos oligoméricos dirigidos a apo(a) están conjugados a N-acetilgalactosamina. Además, en la presente se describen compuestos oligoméricos conjugados dirigidos a apo(a) para usarse en la disminución de la apo(a) para tratar, prevenir o mejorar enfermedades, trastornos o afecciones relacionadas con apo(a) y/o Lp(a). Determinadas enfermedades, trastornos o afecciones relacionadas con apo(a) y/o Lp(a) incluyen enfermedades, trastornos o afecciones inflamatorios, cardiovasculares y/o metabólicos. Los compuestos oligoméricos conjugados descritos en la presente se pueden utilizar para tratar dichas enfermedades, trastornos o afecciones en un individuo que lo necesita.
MX2023014444A 2015-11-06 2018-04-26 Modular la expresion de apolipoproteina (a). MX2023014444A (es)

Applications Claiming Priority (1)

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US201562252392P 2015-11-06 2015-11-06

Publications (1)

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MX2023014444A true MX2023014444A (es) 2023-12-15

Family

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MX2018005277A MX2018005277A (es) 2015-11-06 2016-11-07 Modular la expresion de apolipoproteina (a).
MX2023014444A MX2023014444A (es) 2015-11-06 2018-04-26 Modular la expresion de apolipoproteina (a).

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Country Status (16)

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US (3) US10557137B2 (es)
EP (1) EP3370708A4 (es)
JP (3) JP7486920B2 (es)
KR (2) KR102811595B1 (es)
CN (2) CN113952353A (es)
AU (3) AU2016349625B2 (es)
BR (1) BR122023026882A2 (es)
CA (1) CA2999341A1 (es)
CL (1) CL2018001221A1 (es)
CO (1) CO2018002198A2 (es)
IL (3) IL257647B (es)
MX (2) MX2018005277A (es)
MY (1) MY203086A (es)
PE (2) PE20241347A1 (es)
WO (1) WO2017079739A1 (es)
ZA (1) ZA201801208B (es)

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DK2991656T3 (da) * 2013-05-01 2020-03-23 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
DK4119569T3 (da) * 2015-11-06 2024-08-12 Ionis Pharmaceuticals Inc Konjugerede antisense-forbindelser til anvendelse i behandling
CA2999341A1 (en) 2015-11-06 2017-05-11 Ionis Pharmaceuticals, Inc. Modulating apolipoprotein (a) expression
AU2019377275A1 (en) 2018-11-09 2021-03-25 Novartis Ag Method for reducing the risk of a cardiovascular event with conjugated antisense compounds targeting apo(a)
US20220404378A1 (en) * 2019-11-14 2022-12-22 The Regents Of The University Of California Methods and compositions for determining oxpl-associated diseases and disorders
WO2023180904A1 (en) * 2022-03-21 2023-09-28 Crispr Therapeutics Ag Methods and compositions for treating lipoprotein-related diseases

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