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MX2023011658A - Linajes hematopoyeticos derivados de celulas madre pluripotentes. - Google Patents

Linajes hematopoyeticos derivados de celulas madre pluripotentes.

Info

Publication number
MX2023011658A
MX2023011658A MX2023011658A MX2023011658A MX2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A
Authority
MX
Mexico
Prior art keywords
cells
hematopoietic
lineages
hematopoietic lineages
stem cells
Prior art date
Application number
MX2023011658A
Other languages
English (en)
Inventor
Dhvanit Shah
Original Assignee
Garuda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Garuda Therapeutics Inc filed Critical Garuda Therapeutics Inc
Publication of MX2023011658A publication Critical patent/MX2023011658A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/0602—Vertebrate cells
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  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente divulgación, en diversos aspectos y modalidades, proporciona métodos para generar células de linaje hematopoyético para la terapia con células hematopoyéticas. Los diversos linajes hematopoyéticos incluyen linfocitos T que incluyen células T progenitoras, células asesinas naturales, linfocitos B, neutrófilos, monocitos y/o macrófagos, glóbulos rojos, megacariocitos, y plaquetas. En varias modalidades, la invención proporciona procesos ex vivo eficientes para el desarrollo de linajes hematopoyéticos, que incluye, pero no se limita a, las células T progenitoras y linajes de células T, a partir de células madre pluripotentes inducidas (iPSC) humanas. Las células generadas de acuerdo con la divulgación en varias modalidades son funcionales y/o más se asemejan al linaje correspondiente aislado de sangre periférica o de órganos linfoides. La presente invención en algunos aspectos proporciona células aisladas y composiciones de células producidas por los métodos divulgados en la presente, así como métodos para la terapia celular adoptiva.
MX2023011658A 2021-03-31 2022-03-30 Linajes hematopoyeticos derivados de celulas madre pluripotentes. MX2023011658A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163168360P 2021-03-31 2021-03-31
PCT/US2022/022562 WO2022212514A1 (en) 2021-03-31 2022-03-30 Pluripotent stem cell-derived hematopoietic lineages

Publications (1)

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MX2023011658A true MX2023011658A (es) 2023-12-14

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US (1) US20240180961A1 (es)
EP (1) EP4313082A4 (es)
JP (1) JP2024514091A (es)
KR (1) KR20240037179A (es)
CN (1) CN117597435A (es)
AU (1) AU2022252247A1 (es)
BR (1) BR112023019951A2 (es)
CA (1) CA3214216A1 (es)
IL (1) IL307219A (es)
MX (1) MX2023011658A (es)
WO (1) WO2022212514A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL320067A (en) * 2022-10-05 2025-06-01 Garuda Therapeutics Inc Erythroid lineages derived from pluripotent cells
WO2024248141A1 (ja) * 2023-06-02 2024-12-05 国立大学法人京都大学 Ｔ前駆細胞の製造方法
CN116574672B (zh) * 2023-07-11 2023-10-20 北京北启生物医药有限公司 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法
WO2025219552A1 (en) * 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119799625B (zh) * 2025-03-17 2025-07-15 中国人民解放军军事科学院军事医学研究院 制备骨髓类器官的方法及其所用组合物与培养基

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107429230B (zh) * 2015-01-26 2021-11-12 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
CA3003433A1 (en) * 2015-10-27 2017-05-04 Children's Hospital Medical Center Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation
KR20250141836A (ko) * 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
CN108601356B (zh) * 2015-12-03 2023-01-10 布里格姆妇女医院 生成功能性造血干细胞的方法
JP7215994B2 (ja) * 2016-09-06 2023-01-31 ザ チルドレンズ メディカル センター コーポレーション 人工多能性幹細胞由来の免疫細胞
MX2020013217A (es) * 2018-06-07 2021-05-12 Brigham & Womens Hospital Inc Metodos para generar celulas madre hematopoyeticas.
US12378572B2 (en) * 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
US20220025330A1 (en) * 2019-01-22 2022-01-27 Washington University Compositions and methods for generating hematopoietic stem cells (hscs)
WO2021150919A1 (en) * 2020-01-23 2021-07-29 The Children's Medical Center Corporation Stroma-free t cell differentiation from human pluripotent stem cells
WO2022125947A1 (en) * 2020-12-10 2022-06-16 Garuda Therapeutics, Inc. Methods for generating hematopoietic stem cells and compositions thereof

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JP2024514091A (ja) 2024-03-28
AU2022252247A1 (en) 2023-10-26
CA3214216A1 (en) 2022-10-06
US20240180961A1 (en) 2024-06-06
WO2022212514A1 (en) 2022-10-06
EP4313082A4 (en) 2025-05-28
IL307219A (en) 2023-11-01
EP4313082A1 (en) 2024-02-07
CN117597435A (zh) 2024-02-23
KR20240037179A (ko) 2024-03-21
BR112023019951A2 (pt) 2023-11-14

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