MX2023011556A - Composición farmacéutica para prevenir o tratar la alopecia areata actuando como un antagonista funcional de s1pr1 y s1pr4. - Google Patents
Composición farmacéutica para prevenir o tratar la alopecia areata actuando como un antagonista funcional de s1pr1 y s1pr4.Info
- Publication number
- MX2023011556A MX2023011556A MX2023011556A MX2023011556A MX2023011556A MX 2023011556 A MX2023011556 A MX 2023011556A MX 2023011556 A MX2023011556 A MX 2023011556A MX 2023011556 A MX2023011556 A MX 2023011556A MX 2023011556 A MX2023011556 A MX 2023011556A
- Authority
- MX
- Mexico
- Prior art keywords
- s1pr4
- s1pr1
- preventing
- pharmaceutical composition
- alopecia areata
- Prior art date
Links
- 208000004631 alopecia areata Diseases 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 abstract 2
- 101000653757 Homo sapiens Sphingosine 1-phosphate receptor 4 Proteins 0.000 abstract 2
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 abstract 2
- 102100029803 Sphingosine 1-phosphate receptor 4 Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- -1 sphingolipid compound Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica para prevenir o tratar la alopecia areata que actúa como un antagonista funcional para los subtipos S1PR1 y S1PR4 del receptor S1P, y más particularmente, se refiere a una composición farmacéutica que contiene como un ingrediente activo un compuesto esfingolípido que actúa como antagonista funcional de S1PR1 y S1PR4, no causa efectos secundarios cardiovasculares, y es efectivo para prevenir o tratar la alopecia areata.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263418071P | 2022-10-21 | 2022-10-21 | |
| PCT/KR2023/012725 WO2024085417A1 (ko) | 2022-10-21 | 2023-08-28 | S1pr1과 s1pr4에 대한 기능적 저해제로 작용하는 원형 탈모증의 예방 또는 치료용 약학적 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023011556A true MX2023011556A (es) | 2024-07-19 |
Family
ID=89076468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023011556A MX2023011556A (es) | 2022-10-21 | 2023-08-28 | Composición farmacéutica para prevenir o tratar la alopecia areata actuando como un antagonista funcional de s1pr1 y s1pr4. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11957665B1 (es) |
| EP (1) | EP4606373A1 (es) |
| JP (1) | JP7607376B2 (es) |
| CN (1) | CN118234492A (es) |
| AU (1) | AU2023248144B2 (es) |
| CA (1) | CA3213748C (es) |
| MX (1) | MX2023011556A (es) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4596812A (en) | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| DE602004027932D1 (de) | 2003-09-22 | 2010-08-12 | S Bio Pte Ltd | Benzimidazolderivate: herstellung und pharmazeutische anwendungen |
| BRPI0810123A2 (pt) | 2007-04-23 | 2014-10-29 | Novartis Ag | Derivados de ftalazina e isoquinolina com atividades moduladoras do receptor de s1p |
| ES2652451T3 (es) * | 2013-04-04 | 2018-02-02 | Phytos Co., Ltd. | Nuevo derivado de la fitoesfingosina-1-fosfato, método de preparación del mismo, y composición para prevenir y tratar la pérdida del cabello o para estimular el crecimiento del cabello que comprende el mismo |
| KR101830244B1 (ko) * | 2016-01-20 | 2018-02-21 | 서울대학교 산학협력단 | 신규한 헤테로방향족 고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 s1p 수용체 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR102292989B1 (ko) | 2017-03-29 | 2021-08-26 | 재단법인 아산사회복지재단 | S1pr4를 타겟으로 하는 비알코올성 지방간염 예방 또는 치료용 조성물 |
| AU2021205465A1 (en) | 2020-01-06 | 2022-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| KR102540720B1 (ko) * | 2020-02-18 | 2023-06-08 | 재단법인 아산사회복지재단 | 천식 또는 기관지염 예방 또는 치료용 약학적 조성물 |
| KR102533409B1 (ko) | 2021-11-04 | 2023-05-26 | 주식회사 넥스트젠바이오사이언스 | 2-아미노-2-(2-(1-데실-1h-1,2,3-트라이아졸-4-일)에틸)프로판-1,3-다이올의 신규염 및 이를 포함하는 약학적 조성물 |
-
2023
- 2023-08-28 EP EP23772393.7A patent/EP4606373A1/en active Pending
- 2023-08-28 JP JP2023560621A patent/JP7607376B2/ja active Active
- 2023-08-28 AU AU2023248144A patent/AU2023248144B2/en active Active
- 2023-08-28 CN CN202380010914.3A patent/CN118234492A/zh active Pending
- 2023-08-28 MX MX2023011556A patent/MX2023011556A/es unknown
- 2023-08-28 CA CA3213748A patent/CA3213748C/en active Active
- 2023-09-26 US US18/474,522 patent/US11957665B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023248144A1 (en) | 2024-05-09 |
| US11957665B1 (en) | 2024-04-16 |
| JP7607376B2 (ja) | 2024-12-27 |
| US20240148698A1 (en) | 2024-05-09 |
| EP4606373A1 (en) | 2025-08-27 |
| AU2023248144B2 (en) | 2024-05-23 |
| JP2024539788A (ja) | 2024-10-31 |
| CA3213748A1 (en) | 2023-12-08 |
| CN118234492A (zh) | 2024-06-21 |
| CA3213748C (en) | 2025-02-11 |
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