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MX2023010774A - Pauta posologica de sotorasib. - Google Patents

Pauta posologica de sotorasib.

Info

Publication number
MX2023010774A
MX2023010774A MX2023010774A MX2023010774A MX2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A
Authority
MX
Mexico
Prior art keywords
sotorasib
dosing regimen
patient
total daily
daily dose
Prior art date
Application number
MX2023010774A
Other languages
English (en)
Inventor
Sandeep Dutta
Gregory Friberg
Haby Henary
Gataree Ngarmchamnanrith
Brett E Houk
Omar A Mather
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023010774A publication Critical patent/MX2023010774A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En el presente documento se proporcionan métodos de administración de una dosis diaria total de 240 mg de sotorasib a un paciente que padece un cáncer que tiene una mutación KRAS G12C. En el presente documento también se proporcionan métodos para tratar un cáncer con mutación KRAS G12C en un paciente, que comprenden la administración de una dosis diaria total de 960 mg de sotorasib al paciente, y la reducción de la dosis diaria total de sotorasib a 480 mg en un paciente que experimenta un acontecimiento adverso a la dosis de 960 mg de sotorasib.
MX2023010774A 2021-03-17 2022-03-16 Pauta posologica de sotorasib. MX2023010774A (es)

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