[go: up one dir, main page]

MX2023009615A - Moleculas de union anti-cd123 y usos de estas. - Google Patents

Moleculas de union anti-cd123 y usos de estas.

Info

Publication number
MX2023009615A
MX2023009615A MX2023009615A MX2023009615A MX2023009615A MX 2023009615 A MX2023009615 A MX 2023009615A MX 2023009615 A MX2023009615 A MX 2023009615A MX 2023009615 A MX2023009615 A MX 2023009615A MX 2023009615 A MX2023009615 A MX 2023009615A
Authority
MX
Mexico
Prior art keywords
antigen
antibody
derivative
binding fragment
binding molecules
Prior art date
Application number
MX2023009615A
Other languages
English (en)
Inventor
Paul R Hinton
Manal Amoury
Original Assignee
Igm Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igm Biosciences Inc filed Critical Igm Biosciences Inc
Publication of MX2023009615A publication Critical patent/MX2023009615A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente descripción proporciona un anticuerpo o un fragmento de unión al antígeno o derivado de este que se une específicamente a CD123. También se proporcionan polinucleótidos que codifican el anticuerpo o fragmento de unión al antígeno o derivado de este y vectores y células hospedadoras que comprenden dichos polinucleótidos. La presente descripción proporciona además métodos para producir y/o utilizar un anticuerpo o fragmento de unión al antígeno o derivado de este que se une específicamente a CD123.
MX2023009615A 2021-02-17 2022-02-17 Moleculas de union anti-cd123 y usos de estas. MX2023009615A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163150488P 2021-02-17 2021-02-17
US202163249455P 2021-09-28 2021-09-28
PCT/US2022/016683 WO2022178047A1 (en) 2021-02-17 2022-02-17 Anti-cd123 binding molecules and uses thereof

Publications (1)

Publication Number Publication Date
MX2023009615A true MX2023009615A (es) 2023-08-24

Family

ID=82931699

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023009615A MX2023009615A (es) 2021-02-17 2022-02-17 Moleculas de union anti-cd123 y usos de estas.

Country Status (9)

Country Link
US (1) US20240076392A1 (es)
EP (1) EP4294829A4 (es)
JP (1) JP2024508709A (es)
KR (1) KR20230146022A (es)
AU (1) AU2022221633A1 (es)
CA (1) CA3205834A1 (es)
IL (1) IL304485A (es)
MX (1) MX2023009615A (es)
WO (1) WO2022178047A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3560954T1 (sl) 2014-04-03 2021-11-30 Igm Biosciences, Inc. Spremenjena J-veriga
ES2806500T3 (es) 2015-01-20 2021-02-17 Igm Biosciences Inc Moléculas de unión al receptor de la superfamilia de TNF (factor de necrosis tumoral) y usos de las mismas
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
JP7058213B2 (ja) 2015-09-30 2022-04-21 アイジーエム バイオサイエンシズ インコーポレイテッド 改変ｊ鎖を有する結合分子

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2958942B1 (en) * 2013-02-20 2020-06-03 Novartis AG Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
WO2016141303A2 (en) * 2015-03-04 2016-09-09 Igm Biosciences, Inc. Cd20 binding molecules and uses thereof
TWI790206B (zh) * 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
US11242400B2 (en) * 2016-09-21 2022-02-08 Aptevo Research And Development Llc CD123 binding proteins and related compositions and methods
CN117700549A (zh) * 2016-11-16 2024-03-15 埃博灵克斯股份有限公司 能够结合CD123和TCRα/β的T细胞募集多肽
WO2020061498A1 (en) * 2018-09-20 2020-03-26 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-cd123 immunotherapy
JP2022532868A (ja) * 2019-05-04 2022-07-20 インヒブルクス インコーポレイテッド Ｃｄ１２３結合性ポリペプチド及びその使用

Also Published As

Publication number Publication date
CA3205834A1 (en) 2022-08-25
WO2022178047A1 (en) 2022-08-25
KR20230146022A (ko) 2023-10-18
AU2022221633A1 (en) 2023-08-10
US20240076392A1 (en) 2024-03-07
EP4294829A1 (en) 2023-12-27
JP2024508709A (ja) 2024-02-28
IL304485A (en) 2023-09-01
AU2022221633A9 (en) 2024-07-11
EP4294829A4 (en) 2025-03-19

Similar Documents

Publication Publication Date Title
MX2023009615A (es) Moleculas de union anti-cd123 y usos de estas.
PH12020551211A1 (en) Antibodies binding to gprc5d
WO2021018859A3 (en) Antibodies binding to gprc5d
PH12020551997A1 (en) Psma binding agents and uses thereof
NZ774111A (en) Antibodies binding to cd3
MX2022001934A (es) Moleculas de union multimericas inmunoestimuladoras.
CR20200171A (es) Contorsbodies 2 + 1 biespecíficos
MX2022007635A (es) Anticuerpos que se unen a hla-a2/mage-a4.
EP3812398A3 (en) Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123
TN2019000272A1 (en) Anti-ilt4 antibodies and antigen-binding fragments.
PH12022550195A1 (en) Proteins comprising kallikrein related peptidase 2 antigen binding domains and their uses
MY200335A (en) Bispecific binding proteins and uses thereof
EA201990321A1 (ru) Биспецифические антителоподобные связывающие белки, которые специфически связываются с cd3 и cd123
PH12019502274A1 (en) Antibodies binding to steap-1
AU2020224154A8 (en) Multifunctional molecules that bind to calreticulin and uses thereof
WO2006089230A3 (en) Human monoclonal antibodies to prostate specific membrane antigen (psma)
SA520411849B1 (ar) أجسام مضادة ومتقارنات جسم مضاد مع عقار نوعية من أجل cd123 واستخداماتها
WO2019122052A3 (en) Antibodies binding to hla-a2/wt1
EP4253959A3 (en) Anti-idiotypic antibodies directed to the antigen-binding portion of an bcma-binding molecule
PH12022550035A1 (en) Antibodies which bind to cancer cells and target radionuclides to said cells
MX2024009615A (es) Moleculas de union anti-cd38 y usos de estas
MX2022014636A (es) Construcciones de unión a mageb2.
MX2020000595A (es) Regiones de unión al antígeno contra dominios de fibronectina tipo iii y métodos para su uso.
MX2021007028A (es) Anticuerpo anti-il-17a y uso del mismo.
SG11201806597XA (en) ANTIBODY AGAINST EGFRvIII AND USE THEREOF