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MX2023009483A - Anticuerpos monoclonales para usarse para el tratamiento de sinucleinopatia. - Google Patents

Anticuerpos monoclonales para usarse para el tratamiento de sinucleinopatia.

Info

Publication number
MX2023009483A
MX2023009483A MX2023009483A MX2023009483A MX2023009483A MX 2023009483 A MX2023009483 A MX 2023009483A MX 2023009483 A MX2023009483 A MX 2023009483A MX 2023009483 A MX2023009483 A MX 2023009483A MX 2023009483 A MX2023009483 A MX 2023009483A
Authority
MX
Mexico
Prior art keywords
disease
synucleinopathy
parkinson
agents
treatment
Prior art date
Application number
MX2023009483A
Other languages
English (en)
Inventor
Tom Vink
Rik Rademaker
David Satijn
Pekka Kallunki
Karina Fog
Louise Buur Vesterager
Florence Sotty
Ibrahim John Malik
Den Brink Edward Van
Paul Parren
Stavenhagen Jeffrey B
Ann - Louise BERGSTRÖM
Montezinho Liliana Christina Pereira
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2023009483A publication Critical patent/MX2023009483A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Optics & Photonics (AREA)

Abstract

La presente invención se refiere a nuevos anticuerpos monoclonales que son capaces de unirse específicamente a un epítopo en los aminoácidos 112-117 de la alfa-sinucleína y de las especies truncadas importantes de la misma. Los anticuerpos de la invención pueden usarse para tratar una sinucleinopatía tal como la enfermedad de Parkinson (incluyendo formas idiopáticas y hereditarias de enfermedad de Parkinson), Enfermedad Difusa con Cuerpos de Lewy (DLBD), variante de enfermedad de Alzheimer con cuerpos de Lewy (LBV), enfermedad Combinada de Alzheimer y Parkinson, fallo autonómico puro y atrofia multisistémica. Los anticuerpos de la invención también pueden usarse para diagnosticar o formar imágenes de dichas sinucleinopatías.
MX2023009483A 2015-07-13 2018-01-12 Anticuerpos monoclonales para usarse para el tratamiento de sinucleinopatia. MX2023009483A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1512203.9A GB201512203D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods

Publications (1)

Publication Number Publication Date
MX2023009483A true MX2023009483A (es) 2023-08-22

Family

ID=54013851

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018000504A MX2018000504A (es) 2015-07-13 2016-07-12 Agentes, usos y metodos para el tratamiento de la sinucleinopatia.
MX2023009483A MX2023009483A (es) 2015-07-13 2018-01-12 Anticuerpos monoclonales para usarse para el tratamiento de sinucleinopatia.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018000504A MX2018000504A (es) 2015-07-13 2016-07-12 Agentes, usos y metodos para el tratamiento de la sinucleinopatia.

Country Status (40)

Country Link
US (12) US10800836B2 (es)
EP (2) EP3322722B1 (es)
JP (4) JP7012004B2 (es)
KR (2) KR20250051158A (es)
CN (2) CN115925921A (es)
AR (1) AR105336A1 (es)
AU (1) AU2016292896B2 (es)
CL (1) CL2018000075A1 (es)
CO (1) CO2017012941A2 (es)
CR (2) CR20180021A (es)
DK (1) DK3322722T3 (es)
DO (1) DOP2018000013A (es)
EA (1) EA036499B1 (es)
EC (1) ECSP18002645A (es)
ES (1) ES3028882T3 (es)
FI (1) FI3322722T3 (es)
GB (1) GB201512203D0 (es)
GE (2) GEAP202014670A (es)
HR (1) HRP20250624T1 (es)
HU (1) HUE071541T2 (es)
IL (1) IL256501B (es)
JO (1) JO3692B1 (es)
LT (1) LT3322722T (es)
MA (1) MA42439B1 (es)
MX (2) MX2018000504A (es)
MY (1) MY194944A (es)
NI (1) NI201800006A (es)
PE (1) PE20181049A1 (es)
PH (1) PH12018500016A1 (es)
PL (1) PL3322722T3 (es)
PT (1) PT3322722T (es)
RS (1) RS66840B1 (es)
RU (1) RU2765303C2 (es)
SI (1) SI3322722T1 (es)
SV (1) SV2018005612A (es)
TN (1) TN2018000005A1 (es)
TW (1) TWI729992B (es)
UA (1) UA125501C2 (es)
WO (1) WO2017009312A1 (es)
ZA (1) ZA201708607B (es)

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