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MX2023007150A - Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos. - Google Patents

Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos.

Info

Publication number
MX2023007150A
MX2023007150A MX2023007150A MX2023007150A MX2023007150A MX 2023007150 A MX2023007150 A MX 2023007150A MX 2023007150 A MX2023007150 A MX 2023007150A MX 2023007150 A MX2023007150 A MX 2023007150A MX 2023007150 A MX2023007150 A MX 2023007150A
Authority
MX
Mexico
Prior art keywords
methods
boron containing
pyrazole compounds
compositions
containing pyrazole
Prior art date
Application number
MX2023007150A
Other languages
English (en)
Inventor
Alan Long
Yasheen Zhou
Chun Yu Liu
Chunliang Liu
Shon R Pulley
Keith Andrew Newton Graham
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc
Publication of MX2023007150A publication Critical patent/MX2023007150A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe compuestos de pirazol novedosos que contienen boro, o sus sales farmacéuticamente aceptables, composiciones farmacéuticas que los contienen, y sus usos médicos. Los compuestos de la invención tienen actividad como inhibidores de cinasa Janus (JAK) y son útiles en el tratamiento o control de inflamación, enfermedades autoinmunitarias, cáncer, y otros trastornos e indicaciones donde sería deseable la modulación de JAK. También se describen métodos para tratar inflamación, enfermedades autoinmunitarias, cáncer y otras afecciones que son susceptibles a la inhibición de una cinasa Janus mediante la administración de un compuesto descrito en la presente.
MX2023007150A 2020-12-18 2021-12-13 Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos. MX2023007150A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063127329P 2020-12-18 2020-12-18
PCT/US2021/072885 WO2022133420A1 (en) 2020-12-18 2021-12-13 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof

Publications (1)

Publication Number Publication Date
MX2023007150A true MX2023007150A (es) 2023-09-04

Family

ID=79425773

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023007150A MX2023007150A (es) 2020-12-18 2021-12-13 Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos.

Country Status (11)

Country Link
US (3) US11827657B2 (es)
EP (1) EP4263559A1 (es)
JP (1) JP2023554665A (es)
CN (1) CN117242080A (es)
AR (1) AR124393A1 (es)
AU (1) AU2021401834A1 (es)
CA (1) CA3201608A1 (es)
MX (1) MX2023007150A (es)
TW (1) TW202239416A (es)
UY (1) UY39567A (es)
WO (1) WO2022133420A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023007150A (es) * 2020-12-18 2023-09-04 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos.
CN117486916B (zh) * 2023-12-29 2024-04-12 山东国邦药业有限公司 一种3,4,5-三氟苯硼酸的合成方法
CN119775295B (zh) * 2024-12-30 2025-10-17 南京林业大学 一种烷基偕二频哪醇硼酸酯化合物的合成方法

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EP2343298B9 (en) 2005-12-13 2020-05-06 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
WO2009002451A2 (en) 2007-06-22 2008-12-31 Genera, Doo Adamts4 as a blood biomarker and therapeutic target for chronis renal failure
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
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EP3894403A1 (en) 2018-12-13 2021-10-20 Intervet International B.V. Process for preparing 1-[(3r,4s)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]p yrazole-4-carboxamide
KR20250057082A (ko) 2019-04-24 2025-04-28 엘랑코 유에스 인코포레이티드 7h-피롤로[2,3-d]피리미딘 jak-억제제
JP7592628B2 (ja) 2019-05-02 2024-12-02 インターベット インターナショナル ベー． フェー． ラセミ混合物のキラル分離によるエチル３－アミノ－１－［（３ｒ，４ｓ）－４－シアノテトラヒドロピラン－３－イル］ピラゾール－４－カルボン酸塩の製造方法
MX2023007150A (es) * 2020-12-18 2023-09-04 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos.

Also Published As

Publication number Publication date
US20220194965A1 (en) 2022-06-23
CN117242080A (zh) 2023-12-15
AR124393A1 (es) 2023-03-22
AU2021401834A1 (en) 2023-07-06
WO2022133420A1 (en) 2022-06-23
AU2021401834A9 (en) 2024-09-12
US12404286B2 (en) 2025-09-02
EP4263559A1 (en) 2023-10-25
JP2023554665A (ja) 2023-12-28
US20250382312A1 (en) 2025-12-18
TW202239416A (zh) 2022-10-16
CA3201608A1 (en) 2022-06-23
UY39567A (es) 2022-07-29
US20240352045A1 (en) 2024-10-24
US11827657B2 (en) 2023-11-28

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