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MX2023002942A - Formas cristalinas de un inhibidor de kras g12c. - Google Patents

Formas cristalinas de un inhibidor de kras g12c.

Info

Publication number
MX2023002942A
MX2023002942A MX2023002942A MX2023002942A MX2023002942A MX 2023002942 A MX2023002942 A MX 2023002942A MX 2023002942 A MX2023002942 A MX 2023002942A MX 2023002942 A MX2023002942 A MX 2023002942A MX 2023002942 A MX2023002942 A MX 2023002942A
Authority
MX
Mexico
Prior art keywords
crystalline forms
kras
inhibitor
relates
present
Prior art date
Application number
MX2023002942A
Other languages
English (en)
Inventor
Patricia Andres
Cheng Yi Chen
Jennifer Nelson
Samuel Andrew
Susana Del Rio Gancedo
Tawfik Gharbaoui
Original Assignee
Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of MX2023002942A publication Critical patent/MX2023002942A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con formas cristalinas de un inhibidor de KRas G12C y sal de este. En particular, la presente invención se relaciona con formas cristalinas del inhibidor KRas GT2C 2-[(2S)-4-[7-(8-cloro-1-naftil)-2-[[(2S)-1-metilpirrolidin-2- il]metoxi]-6,8-dihidro-5H-pirido[3,4-d]pirimidin-4-il]-1-(2- fluoroprop-2-enoil)piperazin-2-il]acetonitrilo,composiciones farmacéuticas que comprenden las formas cristalinas, procesos para preparar las formas cristalinas y métodos de uso de estos.
MX2023002942A 2020-09-11 2021-09-10 Formas cristalinas de un inhibidor de kras g12c. MX2023002942A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063077553P 2020-09-11 2020-09-11
US202063093673P 2020-10-19 2020-10-19
PCT/US2021/049940 WO2022056307A1 (en) 2020-09-11 2021-09-10 Crystalline forms of a kras g12c inhibitor

Publications (1)

Publication Number Publication Date
MX2023002942A true MX2023002942A (es) 2023-05-22

Family

ID=80629890

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002942A MX2023002942A (es) 2020-09-11 2021-09-10 Formas cristalinas de un inhibidor de kras g12c.

Country Status (13)

Country Link
US (3) US12286431B2 (es)
EP (1) EP4210833A4 (es)
JP (1) JP2023540809A (es)
KR (1) KR20230137286A (es)
AU (1) AU2021340716A1 (es)
BR (1) BR112023004569A2 (es)
CA (1) CA3190944A1 (es)
CL (1) CL2023000693A1 (es)
CO (1) CO2023004141A2 (es)
IL (1) IL301236A (es)
MX (1) MX2023002942A (es)
WO (1) WO2022056307A1 (es)
ZA (1) ZA202304180B (es)

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