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MX2023000529A - Sintesis de derivados de ester boronato y usos de estos. - Google Patents

Sintesis de derivados de ester boronato y usos de estos.

Info

Publication number
MX2023000529A
MX2023000529A MX2023000529A MX2023000529A MX2023000529A MX 2023000529 A MX2023000529 A MX 2023000529A MX 2023000529 A MX2023000529 A MX 2023000529A MX 2023000529 A MX2023000529 A MX 2023000529A MX 2023000529 A MX2023000529 A MX 2023000529A
Authority
MX
Mexico
Prior art keywords
synthesis
ester derivatives
boronate ester
formula
disclosed
Prior art date
Application number
MX2023000529A
Other languages
English (en)
Inventor
Scott J Hecker
Serge Henri Boyer
Gerardus K M Verzijl
Petrus J Hermsen
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of MX2023000529A publication Critical patent/MX2023000529A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)

Abstract

En la presente descripción se describen los métodos para la preparación de derivados de boronato en la síntesis de compuestos antimicrobianos y sus usos. En la presente descripción se describen los métodos para preparar un compuesto de la Fórmula (B) mediante la reducción del grupo cetona del compuesto cetoéster de la Fórmula (A), y la reducción puede realizarse mediante el uso de un sistema catalítico que se basa en Rutenio o mediante el uso de un sistema de biorreducción de la alcohol deshidrogenasa.
MX2023000529A 2017-11-01 2020-07-13 Sintesis de derivados de ester boronato y usos de estos. MX2023000529A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762580343P 2017-11-01 2017-11-01

Publications (1)

Publication Number Publication Date
MX2023000529A true MX2023000529A (es) 2023-02-13

Family

ID=66245250

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020004425A MX2020004425A (es) 2017-11-01 2018-10-30 Síntesis de derivados de éster boronato y usos de estos.
MX2023000529A MX2023000529A (es) 2017-11-01 2020-07-13 Sintesis de derivados de ester boronato y usos de estos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020004425A MX2020004425A (es) 2017-11-01 2018-10-30 Síntesis de derivados de éster boronato y usos de estos.

Country Status (14)

Country Link
US (3) US11999757B2 (es)
EP (1) EP3704130A4 (es)
JP (1) JP7480050B2 (es)
KR (1) KR20200076730A (es)
CN (2) CN118388347A (es)
AU (1) AU2018360502B2 (es)
CA (1) CA3080763A1 (es)
CL (1) CL2020001143A1 (es)
CO (1) CO2020006299A2 (es)
JO (1) JOP20200101A1 (es)
MX (2) MX2020004425A (es)
PH (1) PH12020550544A1 (es)
SG (1) SG11202003762VA (es)
WO (1) WO2019089542A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3704130A4 (en) 2017-11-01 2021-07-07 Melinta Therapeutics, Inc. SUMMARY OF BORONATE ESTERS DERIVATIVES AND ASSOCIATED USES
CN116789689A (zh) * 2023-06-21 2023-09-22 清华大学 硼代萘系化合物及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
JP2852545B2 (ja) 1989-11-14 1999-02-03 チッソ株式会社 複数の不斉点を持つ光学活性化合物および製造法
CA2165996C (en) 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19917979A1 (de) 1999-04-21 2000-10-26 Clariant Gmbh Verfahren zur Herstellung von substituierten Phenyl-boronsäuren
DE60009836T2 (de) 1999-06-04 2005-04-21 Kaneka Corp Verfahren zur herstellung von 5-hydroxy-3-oxo-pentansäure-derivaten
DE10032017A1 (de) 2000-07-01 2002-01-10 Clariant Gmbh Verfahren zur Herstellung hochreiner Formylphenylboronsäuren
DE10112401A1 (de) * 2001-03-13 2002-09-19 Degussa Alkohol-Dehydrogenase und deren Verwendung
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
JP4824874B2 (ja) * 2001-07-19 2011-11-30 高砂香料工業株式会社 光学活性γ−ブチロラクトンの製造方法
EP1386901B1 (en) * 2002-07-30 2015-07-01 Takasago International Corporation Method for producing an optically active beta-amino acid
TWI372725B (en) 2004-01-30 2012-09-21 Semequip Inc Methods of synthesis of isotopically enriched borohydride and methods of synthesis of isotopically enriched boranes
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
GB2474687A (en) 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
SG187757A1 (en) * 2010-08-10 2013-03-28 Rempex Pharmaceuticals Inc Cyclic boronic acid ester derivatives and therapeutic uses thereof
WO2013056163A1 (en) * 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
WO2013122888A2 (en) * 2012-02-15 2013-08-22 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
US20150105562A1 (en) 2012-08-20 2015-04-16 Manac Inc. Method for preparing borinic acid derivatives and novel borinic acid derivatives
CN102965403A (zh) 2012-11-19 2013-03-13 苏州汉酶生物技术有限公司 (3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的生物制备方法
JP6403219B2 (ja) 2012-12-07 2018-10-10 ベナトルクス ファーマシューティカルズ，インク． ベータ−ラクタマーゼ阻害剤
SI3066071T1 (en) 2013-11-05 2018-08-31 Bracco Imaging S.P.A. Preparation of jopamidol
LT3140310T (lt) * 2014-05-05 2019-11-25 Rempex Pharmaceuticals Inc Boronato druskų sintezė ir jų panaudojimas
EP3704130A4 (en) 2017-11-01 2021-07-07 Melinta Therapeutics, Inc. SUMMARY OF BORONATE ESTERS DERIVATIVES AND ASSOCIATED USES

Also Published As

Publication number Publication date
PH12020550544A1 (en) 2021-03-22
US20240279248A1 (en) 2024-08-22
JP7480050B2 (ja) 2024-05-09
BR112020008498A2 (pt) 2020-10-20
EP3704130A1 (en) 2020-09-09
JP2021501205A (ja) 2021-01-14
AU2018360502A1 (en) 2020-06-04
CN111556872A (zh) 2020-08-18
CN118388347A (zh) 2024-07-26
US20190127396A1 (en) 2019-05-02
WO2019089542A1 (en) 2019-05-09
MX2020004425A (es) 2020-08-06
CA3080763A1 (en) 2019-05-09
CO2020006299A2 (es) 2020-06-09
US20200308197A1 (en) 2020-10-01
US11999757B2 (en) 2024-06-04
SG11202003762VA (en) 2020-05-28
EP3704130A4 (en) 2021-07-07
CN111556872B (zh) 2024-05-10
AU2018360502B2 (en) 2024-05-02
CL2020001143A1 (es) 2020-10-30
KR20200076730A (ko) 2020-06-29
JOP20200101A1 (ar) 2022-10-30

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