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MX2022015132A - Vacunas combinadas a base de acidos nucleicos. - Google Patents

Vacunas combinadas a base de acidos nucleicos.

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Publication number
MX2022015132A
MX2022015132A MX2022015132A MX2022015132A MX2022015132A MX 2022015132 A MX2022015132 A MX 2022015132A MX 2022015132 A MX2022015132 A MX 2022015132A MX 2022015132 A MX2022015132 A MX 2022015132A MX 2022015132 A MX2022015132 A MX 2022015132A
Authority
MX
Mexico
Prior art keywords
nucleic acid
coronavirus
pharmaceutical compositions
infection
virus
Prior art date
Application number
MX2022015132A
Other languages
English (en)
Inventor
Benjamin Petsch
Susanne Rauch
Kim Ellen Schwendt
Cornelia Oostvogels
Original Assignee
CureVac SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CureVac SE filed Critical CureVac SE
Publication of MX2022015132A publication Critical patent/MX2022015132A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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Abstract

La presente invención está dirigida, entre otras cosas, a composiciones farmacéuticas que comprenden al menos un ácido nucleico que codifica para al menos un péptido o proteína antigénico de un coronavirus, preferiblemente un coronavirus pandémico, y al menos un ácido nucleico que codifica para al menos un péptido o proteína antigénico de un virus adicional, por ejemplo, un virus de la influenza o un virus RSV. Las composiciones farmacéuticas proporcionadas en la presente son adecuadas para usarse en el tratamiento o la profilaxis de una infección con al menos un coronavirus y al menos una infección viral adicional y, por lo tanto, pueden estar comprendidas en una vacuna combinada. Las secuencias de ácido nucleico de las composiciones farmacéuticas y las vacunas combinadas están preferiblemente asociadas con un portador polimérico, una proteína o péptido policatiónico o una nanopartícula lipídica (LNP). La invención también se dirige al primer y segundo uso médico y otros usos médicos de las composiciones farmacéuticas y vacunas combinadas, y a métodos para tratar o prevenir una infección por coronavirus y otra infección por virus.
MX2022015132A 2020-05-29 2021-05-27 Vacunas combinadas a base de acidos nucleicos. MX2022015132A (es)

Applications Claiming Priority (3)

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EP2020065094 2020-05-29
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