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MX2022014259A - Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer. - Google Patents

Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer.

Info

Publication number
MX2022014259A
MX2022014259A MX2022014259A MX2022014259A MX2022014259A MX 2022014259 A MX2022014259 A MX 2022014259A MX 2022014259 A MX2022014259 A MX 2022014259A MX 2022014259 A MX2022014259 A MX 2022014259A MX 2022014259 A MX2022014259 A MX 2022014259A
Authority
MX
Mexico
Prior art keywords
inhibitor
combination
cancer
binding molecule
treating cancer
Prior art date
Application number
MX2022014259A
Other languages
English (en)
Inventor
Bruce Alan Keyt
Angus Sinclair
Beatrice Wang
Thomas J Matthew
Eric William Humke
Daniel S Chen
Ling Wang
Original Assignee
Igm Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igm Biosciences Inc filed Critical Igm Biosciences Inc
Publication of MX2022014259A publication Critical patent/MX2022014259A/es

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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente descripción proporciona métodos terapéuticos para tratar el cáncer que incluyen una terapia de combinación con un anticuerpo multimérico anti-DR5 y una terapia contra el cáncer, por ejemplo, radiación, una antraciclina, un análogo del ácido fólico, un agente basado en platino, un taxano, un inhibidor de la topoisomerasa II, un mimético de SMAC, un alcaloide de la vinca, un inhibidor de la tirosina quinasa de Bruton (BTK), un inhibidor de la fosfoinositida 3-quinasa delta (PI3Kd), un inhibidor de la leucemia de células mieloides-1 (Mcl-1), o cualquier combinación de los estos.
MX2022014259A 2020-05-12 2021-05-12 Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer. MX2022014259A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063023635P 2020-05-12 2020-05-12
US202063078747P 2020-09-15 2020-09-15
US202063114990P 2020-11-17 2020-11-17
US202063131698P 2020-12-29 2020-12-29
US202163136156P 2021-01-11 2021-01-11
PCT/US2021/032078 WO2021231639A1 (en) 2020-05-12 2021-05-12 Use of a multimeric anti-dr5 binding molecule in combination with a cancer therapy for treating cancer

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MX2022014259A true MX2022014259A (es) 2022-12-07

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MX2022014259A MX2022014259A (es) 2020-05-12 2021-05-12 Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer.

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US (1) US20230174660A1 (es)
EP (1) EP4149553A4 (es)
JP (1) JP2023526224A (es)
KR (1) KR20230010221A (es)
CN (1) CN115697419A (es)
AU (1) AU2021271647A1 (es)
BR (1) BR112022022145A2 (es)
CA (1) CA3173919A1 (es)
IL (1) IL297619A (es)
MX (1) MX2022014259A (es)
WO (1) WO2021231639A1 (es)

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Publication number Priority date Publication date Assignee Title
SI3560954T1 (sl) 2014-04-03 2021-11-30 Igm Biosciences, Inc. Spremenjena J-veriga
ES2806500T3 (es) 2015-01-20 2021-02-17 Igm Biosciences Inc Moléculas de unión al receptor de la superfamilia de TNF (factor de necrosis tumoral) y usos de las mismas
CA2980751A1 (en) 2015-03-25 2016-09-29 Stephen F. Carroll Multi-valent hepatitis b virus antigen binding molecules and uses thereof
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
JP7058213B2 (ja) 2015-09-30 2022-04-21 アイジーエム バイオサイエンシズ インコーポレイテッド 改変ｊ鎖を有する結合分子
WO2022154664A1 (en) * 2021-01-15 2022-07-21 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer
IL317132A (en) * 2022-05-23 2025-01-01 Inhibrx Biosciences Inc Combination therapy of DR5 agonist and IAP antagonist
WO2024148339A1 (en) * 2023-01-06 2024-07-11 Igm Biosciences, Inc. Use of a multimeric anti-dr5 antibody for treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100847010B1 (ko) * 2006-07-05 2008-07-17 아주대학교산학협력단 세포사멸 수용체 5 (ｄｒ5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물
WO2008066854A2 (en) * 2006-11-28 2008-06-05 Novartis Ag Methods and compositions for inducing apoptosis in cancer cells
AU2009257663B2 (en) * 2008-06-09 2014-06-26 New York Medical College Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium
ES2806500T3 (es) * 2015-01-20 2021-02-17 Igm Biosciences Inc Moléculas de unión al receptor de la superfamilia de TNF (factor de necrosis tumoral) y usos de las mismas
SG11201803956UA (en) * 2015-12-01 2018-06-28 Genmab Bv Anti-dr5 antibodies and methods of use thereof
CA3091140A1 (en) * 2018-02-26 2019-08-29 Igm Biosciences, Inc. Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer
BR112020017296A2 (pt) * 2018-03-01 2020-12-29 Igm Biosciences, Inc. Mutações de igm fc e de cadeia j que afetam a meia-vida sérica de igm

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US20230174660A1 (en) 2023-06-08
CA3173919A1 (en) 2021-11-18
CN115697419A (zh) 2023-02-03
BR112022022145A2 (pt) 2022-12-13
KR20230010221A (ko) 2023-01-18
WO2021231639A1 (en) 2021-11-18
JP2023526224A (ja) 2023-06-21
EP4149553A4 (en) 2024-08-21
EP4149553A1 (en) 2023-03-22
AU2021271647A1 (en) 2022-11-03
IL297619A (en) 2022-12-01

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