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MX2022010216A - Usos y composiciones a base de polifenoles para mejorar la biodisponibilidad oral del hidroxitirol. - Google Patents

Usos y composiciones a base de polifenoles para mejorar la biodisponibilidad oral del hidroxitirol.

Info

Publication number
MX2022010216A
MX2022010216A MX2022010216A MX2022010216A MX2022010216A MX 2022010216 A MX2022010216 A MX 2022010216A MX 2022010216 A MX2022010216 A MX 2022010216A MX 2022010216 A MX2022010216 A MX 2022010216A MX 2022010216 A MX2022010216 A MX 2022010216A
Authority
MX
Mexico
Prior art keywords
hydroxytyrosol
polyphenols
compositions
improving
oral bioavailability
Prior art date
Application number
MX2022010216A
Other languages
English (en)
Inventor
Larramendi José Luis López
Martín Mónica María Olivares
Hortigüela Óscar Bañuelos
Rojo Ruth Blanco
Lobón José Antonio Maldonado
Martínez Luis Pérez
Original Assignee
Biosearch S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch S A filed Critical Biosearch S A
Publication of MX2022010216A publication Critical patent/MX2022010216A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a composiciones de origen natural, que comprenden hidroxitirosol y polifenoles que no son hidroxitirosol y que no se encuentran de forma natural en el olivo (O. europaea), caracterizadas por permitir una biodisponibilidad particularmente alta de hidroxitirosol y una actividad antiaterosclerótica particularmente alta de hidroxitirosol, una vez administrado por vía oral. Dichas composiciones pueden consistir en mezclas de extractos vegetales. La invención también se refiere al uso de dichas composiciones para el tratamiento de enfermedades cardiovasculares, en particular la aterosclerosis.
MX2022010216A 2020-02-28 2021-02-26 Usos y composiciones a base de polifenoles para mejorar la biodisponibilidad oral del hidroxitirol. MX2022010216A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES2020070147 2020-02-28
PCT/EP2021/054840 WO2021170806A1 (en) 2020-02-28 2021-02-26 Uses and compositions based on polyphenols for improving the oral bioavailability of hydroxytyrosol

Publications (1)

Publication Number Publication Date
MX2022010216A true MX2022010216A (es) 2022-09-19

Family

ID=70471066

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010216A MX2022010216A (es) 2020-02-28 2021-02-26 Usos y composiciones a base de polifenoles para mejorar la biodisponibilidad oral del hidroxitirol.

Country Status (10)

Country Link
EP (1) EP4110309A1 (es)
JP (1) JP7627279B2 (es)
KR (1) KR20220123074A (es)
CN (1) CN115003291B (es)
AU (1) AU2021228197A1 (es)
BR (1) BR112022015705A2 (es)
CO (1) CO2022011987A2 (es)
MX (1) MX2022010216A (es)
TW (1) TWI795736B (es)
WO (1) WO2021170806A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250275535A1 (en) * 2024-03-01 2025-09-04 Veos Pharmaceuticals, S.L. Olive tree biomass extract

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
US6258846B1 (en) 1999-06-01 2001-07-10 Drugtech Corporation Nutritional supplements
US7112609B2 (en) 1999-06-01 2006-09-26 Drugtech Corporation Nutritional supplements
ES2288123B1 (es) * 2006-06-05 2008-10-01 Furfural Español, S.A. Composicion alimentaria funcional rica en compuestos fenolicos y uso de dicha composicion.
CN101516364B (zh) * 2006-07-14 2011-12-28 帝斯曼知识产权资产管理有限公司 组合物及其用于治疗、共治疗或预防炎性病症的用途
MX2010000832A (es) * 2007-07-23 2010-07-06 Probelte Pharma S A Enriquecimiento de productos nutricionales con extractos de oliva conteniendo hidroxitirosol y productos nutricionales enriquecidos con hidroxitirosol.
FR2942224B1 (fr) * 2009-02-18 2012-11-30 Centre De Cooperation Internationale En Rech Agronomique Pour Le Developpement Cirad Procede d'extraction de composes phenoliques a partir d'eau de vegetation de l'olive et preparation d'extrait titre en polyphenols d'olive et de raisin
ES2592210T3 (es) * 2009-04-17 2016-11-28 Dsm Ip Assets B.V. Combinaciones de hidroxitirosol para mejorar la función mitocondrial y producción de energía
EP2338500A1 (en) * 2009-12-23 2011-06-29 Phenofarm S.r.l. Process for producing concentrated and refined actives from tissues and byproducts of Olea europaea with membrane technologies
JP2016520603A (ja) * 2013-05-29 2016-07-14 ネステク ソシエテ アノニム 軟骨破壊における使用のための組成物
WO2015006651A1 (en) * 2013-07-11 2015-01-15 Specialty Nutrition Group, Inc. Compositions comprising hydroxytyrosol, resveratrol, lycopene, flavanols, and/or flavonoids and use thereof
CA2920601C (en) * 2013-08-09 2021-07-27 Suntory Holdings Limited Agent for promoting in vivo absorption of hydroxytyrosol and derivatives thereof and use of same

Also Published As

Publication number Publication date
JP2023514680A (ja) 2023-04-07
WO2021170806A1 (en) 2021-09-02
TW202131912A (zh) 2021-09-01
JP7627279B2 (ja) 2025-02-05
CN115003291B (zh) 2024-10-29
KR20220123074A (ko) 2022-09-05
CO2022011987A2 (es) 2022-09-09
CN115003291A (zh) 2022-09-02
BR112022015705A2 (pt) 2022-09-27
EP4110309A1 (en) 2023-01-04
TWI795736B (zh) 2023-03-11
AU2021228197A1 (en) 2022-07-07

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