[go: up one dir, main page]

MX2022009962A - Vacunas y usos de la mismas para inducir una respuesta inmunitaria al sars-cov-2. - Google Patents

Vacunas y usos de la mismas para inducir una respuesta inmunitaria al sars-cov-2.

Info

Publication number
MX2022009962A
MX2022009962A MX2022009962A MX2022009962A MX2022009962A MX 2022009962 A MX2022009962 A MX 2022009962A MX 2022009962 A MX2022009962 A MX 2022009962A MX 2022009962 A MX2022009962 A MX 2022009962A MX 2022009962 A MX2022009962 A MX 2022009962A
Authority
MX
Mexico
Prior art keywords
cov2
sars
vaccines
induce
immune response
Prior art date
Application number
MX2022009962A
Other languages
English (en)
Inventor
Mary Jo Hauser
Arban Domi
Farshad Guirakhoo
Original Assignee
Geovax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geovax Inc filed Critical Geovax Inc
Publication of MX2022009962A publication Critical patent/MX2022009962A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
    • C12N15/8636—Vaccina virus vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
    • C12N2760/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

En el presente documento se proporcionan vectores virales de la vaccinia Ankara modificada recombinantes (rMVA) que comprenden insertos de aminoácidos heterólogas que codifican uno o más de proteínas, péptidos y fragmentos de estos de SARS-CoV-2, unidos operativamente a un promotor compatible con sistemas de expresión de poxvirus que, al expresarse, son capaces de inducir inmunidad de protección. Las composiciones pueden utilizarse en una estrategia de primovacunación o en una estrategia de vacunación primaria y revacunación para proporcionar inmunidad contra el SARS-CoV-2 y sus variantes.
MX2022009962A 2020-02-14 2021-02-12 Vacunas y usos de la mismas para inducir una respuesta inmunitaria al sars-cov-2. MX2022009962A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062976913P 2020-02-14 2020-02-14
US202062977402P 2020-02-16 2020-02-16
US202062992710P 2020-03-20 2020-03-20
US202063026580P 2020-05-18 2020-05-18
PCT/US2021/018033 WO2021163622A1 (en) 2020-02-14 2021-02-12 Vaccines and uses thereof to induce an immune response to sars-cov2

Publications (1)

Publication Number Publication Date
MX2022009962A true MX2022009962A (es) 2022-11-09

Family

ID=77292751

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009962A MX2022009962A (es) 2020-02-14 2021-02-12 Vacunas y usos de la mismas para inducir una respuesta inmunitaria al sars-cov-2.

Country Status (12)

Country Link
US (1) US20220396810A1 (es)
EP (1) EP4103231A4 (es)
JP (1) JP2023513611A (es)
KR (1) KR20220154114A (es)
CN (1) CN115529817A (es)
AU (1) AU2021220991A1 (es)
BR (1) BR112022014884A2 (es)
CA (1) CA3167052A1 (es)
IL (1) IL295482A (es)
MX (1) MX2022009962A (es)
TW (1) TW202140794A (es)
WO (1) WO2021163622A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020257317A1 (en) * 2019-06-18 2020-12-24 Citranvi Biosciences, Llc Rationally engineered carrier proteins for vaccines
US11241493B2 (en) 2020-02-04 2022-02-08 Curevac Ag Coronavirus vaccine
US12194089B2 (en) 2020-02-04 2025-01-14 CureVac SE Coronavirus vaccine
MX2022010985A (es) * 2020-03-04 2023-04-19 Premas Biotech Pvt Ltd Expresión de proteínas sars-cov, constructos de ácido nucleico, proteínas tipo virus (vlp) y métodos relevantes a los mismos.
TW202204622A (zh) * 2020-04-09 2022-02-01 大陸商蘇州艾博生物科技有限公司 針對冠狀病毒之核酸疫苗
WO2021250219A1 (en) * 2020-06-10 2021-12-16 Bavarian Nordic A/S A recombinant modified vaccinia virus ankara (mva) vaccine against coronavirus disease
EP4190902A4 (en) * 2020-07-31 2024-09-25 Tokyo Metropolitan Institute of Medical Science Recombinant vaccinia virus
CA3205569A1 (en) 2020-12-22 2022-06-30 CureVac SE Rna vaccine against sars-cov-2 variants
US20230002780A1 (en) * 2021-06-25 2023-01-05 Applied Biotechnology Institute, Inc. EXPRESSION OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2) SPIKE PROTEIN SEQUENCES IN PLANTS AND PLANT PRODUCED VACCINE FOR SAME
WO2023020939A1 (en) * 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
KR20230031756A (ko) * 2021-08-27 2023-03-07 한국과학기술원 신종 코로나바이러스 감염증 대응 예방 백신 조성물
JP2024538872A (ja) * 2021-10-07 2024-10-24 グローバル・ライフ・サイエンシズ・ソリューションズ・カナダ・ユーエルシー Ｒｎａワクチン脂質ナノ粒子
WO2023069461A2 (en) * 2021-10-19 2023-04-27 Vaxxinity, Inc. Method for the prevention and treatment of coronavirus disease
US20250026794A1 (en) * 2021-11-17 2025-01-23 City Of Hope Methods of preventing, treating, or reducing the severity of coronavirus disease 2019 (covid-19)
WO2023200858A1 (en) * 2022-04-13 2023-10-19 The Trustees Of Columbia University In The City Of New York Inhibitory peptides against coronaviruses
DE202023106198U1 (de) 2022-10-28 2024-03-21 CureVac SE Impfstoff auf Nukleinsäurebasis
GB2624391A (en) * 2022-11-15 2024-05-22 Univ Cape Town Recombinant LSDV vectored bovine coronavirus antigen constructs
WO2024118079A1 (en) * 2022-12-01 2024-06-06 Vaxxinity, Inc. Method for the prevention and treatment of coronavirus disease
WO2024206243A1 (en) * 2023-03-24 2024-10-03 Geovax. Inc. Pan-betacoronavirus vaccines and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9045727B2 (en) * 2002-05-17 2015-06-02 Emory University Virus-like particles, methods of preparation, and immunogenic compositions
US8080642B2 (en) * 2003-05-16 2011-12-20 Vical Incorporated Severe acute respiratory syndrome DNA compositions and methods of use
CN1918288A (zh) * 2003-06-20 2007-02-21 蛋白质科学公司 表达sars免疫原的载体、含所述载体或其表达产物的组合物、制备和使用方法和实验
US7396914B2 (en) * 2003-08-04 2008-07-08 University Of Massachusetts SARS nucleic acids, proteins, antibodies, and uses thereof
AU2005251738A1 (en) * 2004-06-02 2005-12-22 New York Blood Center, Inc. SARS vaccines and methods to produce highly potent antibodies
JPWO2006022215A1 (ja) * 2004-08-23 2008-05-08 財団法人ヒューマンサイエンス振興財団 ＳＡＲＳ−コロナウイルスタンパク質をコードするＤＮＡを保有する組換えワクチニアウイルスＤＩｓ株、およびその利用
EP3312272B1 (en) * 2004-10-08 2019-08-28 The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services Modulation of replicative fitness by using less frequently used synonymous codons
CN100479858C (zh) * 2005-01-27 2009-04-22 中国医学科学院实验动物研究所 一种重组痘苗-sars疫苗及其制备方法
TWI526539B (zh) * 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
US11278607B2 (en) * 2016-01-08 2022-03-22 Geovax, Inc. Compositions and methods for generating an immune response to a tumor associated antigen
SI3402888T1 (sl) * 2016-01-12 2021-02-26 Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Sredstva in metode za zdravljenje HBV
CA3026054A1 (en) * 2016-05-30 2017-12-07 Geovax Inc. Compositions and methods for generating an immune response to hepatitis b virus
EP3595676A4 (en) * 2017-03-17 2021-05-05 Modernatx, Inc. RNA VACCINES AGAINST ZOONOSES
JP2023515582A (ja) * 2020-02-26 2023-04-13 トニックス ファーマ リミテッド ＳＡＲＳ－ＣｏＶ－２ウイルスに対する、組換えポックスウイルスに基づくワクチン
US11130787B2 (en) * 2020-06-11 2021-09-28 MBF Therapeutics, Inc. Alphaherpesvirus glycoprotein d-encoding nucleic acid constructs and methods
EP3928789A1 (en) * 2020-06-24 2021-12-29 Consejo Superior de Investigaciones Científicas (CSIC) Mva-based vaccine against covid-19 expressing sars-cov-2 antigens

Also Published As

Publication number Publication date
EP4103231A4 (en) 2024-03-27
AU2021220991A1 (en) 2022-09-29
EP4103231A1 (en) 2022-12-21
TW202140794A (zh) 2021-11-01
US20220396810A1 (en) 2022-12-15
WO2021163622A1 (en) 2021-08-19
IL295482A (en) 2022-10-01
BR112022014884A2 (pt) 2022-10-11
JP2023513611A (ja) 2023-03-31
CA3167052A1 (en) 2021-08-19
KR20220154114A (ko) 2022-11-21
CN115529817A (zh) 2022-12-27

Similar Documents

Publication Publication Date Title
MX2022009962A (es) Vacunas y usos de la mismas para inducir una respuesta inmunitaria al sars-cov-2.
MX2021003175A (es) Vacuna contra el virus de la peste porcina africana.
MX2022010588A (es) Vacuna basada en poxvirus recombinantes contra el virus sars-cov-2.
MX2017002791A (es) Vacuna contra filovirus de virus vaccinia ankara modificado (mva) recombinante.
Herbert et al. Recombinant adenovirus expressing the haemagglutinin of peste des petits ruminants virus (PPRV) protects goats against challenge with pathogenic virus; a DIVA vaccine for PPR
JP2016510989A5 (es)
CA2293692A1 (en) Methods and reagents for vaccination which generate a cd8 t cell immune response
MX2021015465A (es) Vacuna para fiebre porcina africana.
AU2009303788B2 (en) Smallpox DNA vaccine and the antigens therein that elicit an immune response
Baur et al. Immediate-early expression of a recombinant antigen by modified vaccinia virus ankara breaks the immunodominance of strong vector-specific B8R antigen in acute and memory CD8 T-cell responses
MXPA02006888A (es) Flavivirus recombinantes y metodos para utilizar los mismos.
ZA201707985B (en) Recombinant modified vaccinia virus ankara (mva) foot and mouth disease virus (fmdv) vaccine
WO2014205579A4 (en) Modified matrix proteins of vesicular stomatitis virus
WO2006037038B1 (en) Optimized vaccines to provide protection against ebola and other viruses
JP2017503479A5 (es)
WO2005046621A3 (en) Enhancement of vaccine-induced immune responses and protection by heterologous boosting with alphavirus replicon vaccines
RU2018122755A (ru) Слитые белки fmdv-e2 и их применение
NZ598605A (en) Vaccine against african horse sickness virus
WO2006073431A3 (en) Avipox recombinants expressing foot and mouth disease virus genes
MX390966B (es) Vacunas contra el dengue
RU2017132190A (ru) Гибридные белки, содержащие модифицированные поверхностные гликопротеины альфавируса и опухолеассоциированный антиген, и способы, связанные с ними
US20090053256A1 (en) Poxvirus Methods And Compositions
ZA202309287B (en) Coronavirus vaccine comprising a mosaic protein
WO2008127307A3 (en) Induction of an immune response against dengue virus using prime-boost approach
ZA202310905B (en) Adenoviral vectors encoding hepatitis b viral antigens fused to herpes virus glycoprotein d and methods of using the same