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MX2022009187A - Antifolatos poliglutamados alfa y gamma-d y sus usos. - Google Patents

Antifolatos poliglutamados alfa y gamma-d y sus usos.

Info

Publication number
MX2022009187A
MX2022009187A MX2022009187A MX2022009187A MX2022009187A MX 2022009187 A MX2022009187 A MX 2022009187A MX 2022009187 A MX2022009187 A MX 2022009187A MX 2022009187 A MX2022009187 A MX 2022009187A MX 2022009187 A MX2022009187 A MX 2022009187A
Authority
MX
Mexico
Prior art keywords
polyglutamated antifolates
alpha
gamma
antifolates
polyglutamated
Prior art date
Application number
MX2022009187A
Other languages
English (en)
Inventor
Clet Niyikiza
Victor Mandla Moyo
Original Assignee
L E A F Holdings Group Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/675,701 external-priority patent/US20180236098A1/en
Application filed by L E A F Holdings Group Llc filed Critical L E A F Holdings Group Llc
Publication of MX2022009187A publication Critical patent/MX2022009187A/es

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    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Communicable Diseases (AREA)
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  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
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Abstract

La descripción hace referencia, en términos generales, a antifolatos poliglutamados, formulaciones que contienen liposomas rellenos con antifolatos poliglutamados alfa o D-gamma, métodos para realizar las formulaciones que contienen liposomas y los antifolatos poliglutamados, así como métodos para utilizar formulaciones que contienen liposomas y antifolatos poliglutamados para tratar trastornos hiperproliferativos (p. ej., cáncer) y trastornos del sistema inmunológico (p. ej., una enfermedad autoinmune, como artritis reumatoide).
MX2022009187A 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos. MX2022009187A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662374458P 2016-08-12 2016-08-12
US201715675695A 2017-08-11 2017-08-11
US15/675,701 US20180236098A1 (en) 2016-08-12 2017-08-11 Alpha and gamma-d polyglutamated antifolates and uses thereof

Publications (1)

Publication Number Publication Date
MX2022009187A true MX2022009187A (es) 2022-08-18

Family

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Family Applications (5)

Application Number Title Priority Date Filing Date
MX2019001755A MX2019001755A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados y sus usos.
MX2019001756A MX2019001756A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2023007496A MX2023007496A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados y sus usos.
MX2022009187A MX2022009187A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2023007726A MX2023007726A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos.

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MX2019001755A MX2019001755A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados y sus usos.
MX2019001756A MX2019001756A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2023007496A MX2023007496A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados y sus usos.

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Country Status (9)

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US (11) US11344628B2 (es)
EP (3) EP4052729A1 (es)
JP (6) JP7227123B2 (es)
KR (6) KR20240141854A (es)
CN (4) CN121177507A (es)
AU (4) AU2017308158B2 (es)
CA (3) CA3033077C (es)
EA (1) EA201990473A1 (es)
MX (5) MX2019001755A (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180236098A1 (en) 2016-08-12 2018-08-23 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
CN121177507A (zh) 2016-08-12 2025-12-23 L.E.A.F.控股集团公司 α和γ-D聚谷氨酸化抗叶酸剂及其用途
WO2019157133A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
EP3749313A4 (en) * 2018-02-07 2022-03-16 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATE ANTIFOLATES AND ASSOCIATED USES
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
WO2019157121A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated lometrexol and uses thereof
CA3090506A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated tetrahydrofolates and uses thereof
WO2019157148A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
EP3749311A4 (en) * 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
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