MX2022002039A - Compuestos farmaceuticos. - Google Patents
Compuestos farmaceuticos.Info
- Publication number
- MX2022002039A MX2022002039A MX2022002039A MX2022002039A MX2022002039A MX 2022002039 A MX2022002039 A MX 2022002039A MX 2022002039 A MX2022002039 A MX 2022002039A MX 2022002039 A MX2022002039 A MX 2022002039A MX 2022002039 A MX2022002039 A MX 2022002039A
- Authority
- MX
- Mexico
- Prior art keywords
- halo
- independently
- absent
- bonds
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a derivados de benzodiazepina de fórmula (I): (ver fórmula I) en donde: cada uno de R1 y R2 es independientemente H o halo; ya sea (i) T es N, Z es C, ---a---y ---c--- son enlaces, y ---b--- y ---d--- están ausentes; o (ii) T es C, Z es N, ---b--- y ---d--- son enlaces, y ---a--- y ---c--- están ausentes; cada uno de R3 y R4 es independientemente halo, - OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 o -R6; R5 es H o halo; cada uno de R6 y R7 es independientemente H o un grupo seleccionado a partir de alquilo C1-C6, cicloalquilo C3-C10, arilo C6-C10, heterociclilo de 4- a 10-elementos y heteroarilo de 4- a 10-elementos, el grupo es no sustituido o sustituido; R8 es H o alquilo C1-C6, cada R8 siendo el mismo o diferente cuando dos están presentes; n es 0 o 1; y uno de V, W, X y Y es N o CH y los otros tres son CH; y las sales de los mismos farmacéuticamente aceptables son inhibidores de RSV y por lo tanto, son usados para tratar o prevenir una infección por RSV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1911944.5A GB201911944D0 (en) | 2019-08-20 | 2019-08-20 | Pharmaceutical compounds |
| PCT/GB2020/052008 WO2021032992A1 (en) | 2019-08-20 | 2020-08-20 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022002039A true MX2022002039A (es) | 2022-03-11 |
Family
ID=68099512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022002039A MX2022002039A (es) | 2019-08-20 | 2020-08-20 | Compuestos farmaceuticos. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12227507B2 (es) |
| EP (1) | EP4017856A1 (es) |
| JP (1) | JP7722981B2 (es) |
| KR (1) | KR20220075317A (es) |
| CN (1) | CN114555604B (es) |
| AU (1) | AU2020334296A1 (es) |
| BR (1) | BR112022003152A2 (es) |
| CA (1) | CA3151232A1 (es) |
| CO (1) | CO2022003123A2 (es) |
| GB (1) | GB201911944D0 (es) |
| MX (1) | MX2022002039A (es) |
| PE (1) | PE20221397A1 (es) |
| WO (1) | WO2021032992A1 (es) |
| ZA (1) | ZA202202375B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201613942D0 (en) * | 2016-08-15 | 2016-09-28 | Univ Of Durham The | An antimicrobial compound |
| GB201911944D0 (en) * | 2019-08-20 | 2019-10-02 | Reviral Ltd | Pharmaceutical compounds |
| GB201915273D0 (en) * | 2019-10-22 | 2019-12-04 | Reviral Ltd | Pharmaceutical compounds |
| GB201915932D0 (en) | 2019-11-01 | 2019-12-18 | Reviral Ltd | Pharmaceutical compounds |
| GB202010409D0 (en) * | 2020-07-07 | 2020-08-19 | Reviral Ltd | Pharmaceutical compounds |
| GB202102602D0 (en) * | 2021-02-24 | 2021-04-07 | Reviral Ltd | Pharmaceutical compounds |
| WO2024252355A1 (en) | 2023-06-08 | 2024-12-12 | Pfizer Inc. | Pediatric dosing regimens comprising a fusion inhibitor for the treatment of rsv |
| WO2025120500A1 (en) | 2023-12-06 | 2025-06-12 | Pfizer Inc. | Benzodiazepine compounds as n-protein inhibitors |
| WO2025153942A1 (en) | 2024-01-16 | 2025-07-24 | Pfizer Inc. | Benzodiazepine pyrazolo carboxamides as n-protein inhibitors |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4628084A (en) * | 1986-01-02 | 1986-12-09 | Merck & Co., Inc. | Process for 3-acylamino benzodiazepines |
| HUP0402535A2 (hu) * | 2001-12-10 | 2005-04-28 | Bristol-Myers Squibb Co. | RSV fúzió inhibitor hatású imidazo-piridin-vegyület dihidroklorid-monohidrát sója és az ezt tartalmazó gyógyszerkészítmények |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| NZ538870A (en) | 2002-09-20 | 2007-04-27 | Arrow Therapeutics Ltd | Benzodiazepine derivatives and pharmaceutical compositions containing them |
| GB0221923D0 (en) * | 2002-09-20 | 2002-10-30 | Arrow Therapeutics Ltd | Chemical compounds |
| ES2314418T3 (es) | 2003-05-02 | 2009-03-16 | Elan Pharmaceuticals, Inc. | Derivados de amidas del acido 4-bromo-5-(2-clorobenzoilamino)-1h-pirazol-3-carboxicilico y compuestos relacionados como antagonistas del receptor b1 de bradiquinina para el tratamiento de enfermedades inflamatorias. |
| GB0312365D0 (en) | 2003-05-30 | 2003-07-02 | Univ Aston | Novel 3-substituted-1, 4-benzodiazepines |
| GB0406279D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| WO2005090319A1 (en) | 2004-03-19 | 2005-09-29 | Arrow Therapeutics Limited | Process for preparing benzodiazepines |
| GB0406282D0 (en) | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| GB0406280D0 (en) | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Chemical compounds |
| US20070032475A1 (en) | 2005-04-15 | 2007-02-08 | Ye Xiaocong M | Novel compounds useful for bradykinin B1 receptor antagonism |
| CN101267825B (zh) * | 2005-09-19 | 2011-12-28 | 阿罗治疗有限公司 | 治疗丙型肝炎感染的苯并二氮杂*衍生物 |
| US20110059043A1 (en) | 2009-09-03 | 2011-03-10 | Arrow Therapeutics Limited | Chemical compounds |
| WO2011151652A1 (en) | 2010-06-03 | 2011-12-08 | Arrow Therapeutics Limited | Benzodiazepine compounds useful for the treatment of hepatitis c |
| WO2011151651A1 (en) | 2010-06-03 | 2011-12-08 | Arrow Therapeutics Limited | Benzodiazepine compounds useful for the treatment of hepatitis c |
| GB201506448D0 (en) | 2015-04-16 | 2015-06-03 | Univ Durham | An antimicrobial compound |
| RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
| GB201613942D0 (en) | 2016-08-15 | 2016-09-28 | Univ Of Durham The | An antimicrobial compound |
| US10647854B2 (en) | 2016-11-01 | 2020-05-12 | Milliken & Company | Leuco polymers as bluing agents in laundry care compositions |
| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| WO2018152413A1 (en) | 2017-02-16 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| UY38614A (es) | 2019-03-18 | 2020-10-30 | Enanta Pharm Inc | Derivados de benzodiazepinas como inhibidores del rsv |
| GB201911944D0 (en) | 2019-08-20 | 2019-10-02 | Reviral Ltd | Pharmaceutical compounds |
| GB201915273D0 (en) | 2019-10-22 | 2019-12-04 | Reviral Ltd | Pharmaceutical compounds |
| GB201915932D0 (en) | 2019-11-01 | 2019-12-18 | Reviral Ltd | Pharmaceutical compounds |
| GB202010409D0 (en) | 2020-07-07 | 2020-08-19 | Reviral Ltd | Pharmaceutical compounds |
| GB202010408D0 (en) | 2020-07-07 | 2020-08-19 | Reviral Ltd | Pharmaceutical compounds |
-
2019
- 2019-08-20 GB GBGB1911944.5A patent/GB201911944D0/en not_active Ceased
-
2020
- 2020-08-20 WO PCT/GB2020/052008 patent/WO2021032992A1/en not_active Ceased
- 2020-08-20 EP EP20764728.0A patent/EP4017856A1/en active Pending
- 2020-08-20 MX MX2022002039A patent/MX2022002039A/es unknown
- 2020-08-20 PE PE2022000276A patent/PE20221397A1/es unknown
- 2020-08-20 US US17/636,510 patent/US12227507B2/en active Active
- 2020-08-20 AU AU2020334296A patent/AU2020334296A1/en active Pending
- 2020-08-20 KR KR1020227009222A patent/KR20220075317A/ko active Pending
- 2020-08-20 BR BR112022003152A patent/BR112022003152A2/pt unknown
- 2020-08-20 CA CA3151232A patent/CA3151232A1/en active Pending
- 2020-08-20 JP JP2022511130A patent/JP7722981B2/ja active Active
- 2020-08-20 CN CN202080072206.9A patent/CN114555604B/zh active Active
-
2022
- 2022-02-24 ZA ZA2022/02375A patent/ZA202202375B/en unknown
- 2022-03-18 CO CONC2022/0003123A patent/CO2022003123A2/es unknown
- 2022-06-21 US US17/845,187 patent/US11634425B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202202375B (en) | 2024-07-31 |
| GB201911944D0 (en) | 2019-10-02 |
| EP4017856A1 (en) | 2022-06-29 |
| JP7722981B2 (ja) | 2025-08-13 |
| US12227507B2 (en) | 2025-02-18 |
| US11634425B2 (en) | 2023-04-25 |
| US20220324873A1 (en) | 2022-10-13 |
| WO2021032992A1 (en) | 2021-02-25 |
| CO2022003123A2 (es) | 2022-05-10 |
| KR20220075317A (ko) | 2022-06-08 |
| CN114555604A (zh) | 2022-05-27 |
| US20220306639A1 (en) | 2022-09-29 |
| AU2020334296A1 (en) | 2022-03-10 |
| BR112022003152A2 (pt) | 2022-05-17 |
| CN114555604B (zh) | 2024-11-15 |
| PE20221397A1 (es) | 2022-09-14 |
| JP2022545249A (ja) | 2022-10-26 |
| CA3151232A1 (en) | 2021-02-25 |
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