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MX2021011034A - Metodos y composiciones para el tratamiento del cancer. - Google Patents

Metodos y composiciones para el tratamiento del cancer.

Info

Publication number
MX2021011034A
MX2021011034A MX2021011034A MX2021011034A MX2021011034A MX 2021011034 A MX2021011034 A MX 2021011034A MX 2021011034 A MX2021011034 A MX 2021011034A MX 2021011034 A MX2021011034 A MX 2021011034A MX 2021011034 A MX2021011034 A MX 2021011034A
Authority
MX
Mexico
Prior art keywords
compositions
methods
treating cancer
subject
disrupts
Prior art date
Application number
MX2021011034A
Other languages
English (en)
Inventor
Joon Seok Park
Francesca S Gazzaniga
Arlene H Sharpe
Dennis Kasper
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of MX2021011034A publication Critical patent/MX2021011034A/es

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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Immunology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

En el presente documento se proporcionan métodos y composiciones para tratar el cáncer o un tumor en un sujeto administrando al sujeto un primer agente que interrumpe la interacción entre PD-L2 / RGMb y un segundo agente que interrumpe la interacción entre PD-1 / PD-L1. El sujeto puede tener disbiosis y / o no responder a la terapia de puntos de control inmunológico.
MX2021011034A 2019-03-12 2020-03-12 Metodos y composiciones para el tratamiento del cancer. MX2021011034A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962817231P 2019-03-12 2019-03-12
US202062963742P 2020-01-21 2020-01-21
PCT/US2020/022384 WO2020186053A1 (en) 2019-03-12 2020-03-12 Methods and compositions for treating cancer

Publications (1)

Publication Number Publication Date
MX2021011034A true MX2021011034A (es) 2021-11-12

Family

ID=70190198

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021011034A MX2021011034A (es) 2019-03-12 2020-03-12 Metodos y composiciones para el tratamiento del cancer.

Country Status (11)

Country Link
US (2) US20220204604A1 (es)
EP (2) EP4112125A1 (es)
JP (1) JP2022523779A (es)
KR (1) KR20210144754A (es)
CN (2) CN114040799A (es)
AU (1) AU2020237225A1 (es)
BR (1) BR112021017864A2 (es)
CA (1) CA3132199A1 (es)
IL (2) IL295153A (es)
MX (1) MX2021011034A (es)
WO (1) WO2020186053A1 (es)

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CA3132199A1 (en) * 2019-03-12 2020-09-17 President And Fellows Of Harvard College Methods and compositions for treating cancer
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WO2023150181A1 (en) * 2022-02-01 2023-08-10 President And Fellows Of Harvard College Methods and compositions for treating cancer

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WO2020186053A1 (en) 2020-09-17
CA3132199A1 (en) 2020-09-17
CN114040799A (zh) 2022-02-11
JP2022523779A (ja) 2022-04-26
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