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MX2021008918A - Moduladores de expresion yap1. - Google Patents

Moduladores de expresion yap1.

Info

Publication number
MX2021008918A
MX2021008918A MX2021008918A MX2021008918A MX2021008918A MX 2021008918 A MX2021008918 A MX 2021008918A MX 2021008918 A MX2021008918 A MX 2021008918A MX 2021008918 A MX2021008918 A MX 2021008918A MX 2021008918 A MX2021008918 A MX 2021008918A
Authority
MX
Mexico
Prior art keywords
yap1
compound
certain embodiments
expression
useful
Prior art date
Application number
MX2021008918A
Other languages
English (en)
Inventor
Youngsoo Kim
Huynh-Hoa Bui
Susan M Freier
Robert Macleod
Xiaolin Luo
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2021008918A publication Critical patent/MX2021008918A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

Las presentes modalidades proporcionan métodos, compuestos y composiciones útiles para inhibir la expresión de YAP1, que pueden ser útiles para tratar, prevenir o mejorar un cáncer asociado a YAP1. Determinadas modalidades proporcionadas en el presente documento se refieren a métodos para inhibir la expresión de YAPI, que pueden ser útiles para tratar, prevenir o mejorar un cáncer asociado con YAP1 en un individuo, mediante la administración de un compuesto que se dirige a YAP1. En determinadas modalidades, el compuesto puede ser un inhibidor específico de YAP. En determinadas modalidades, el compuesto puede ser un compuesto antisentido, un compuesto oligomérico o un oligonucleótido dirigido a YAPI.
MX2021008918A 2019-01-31 2020-01-31 Moduladores de expresion yap1. MX2021008918A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962799591P 2019-01-31 2019-01-31
US201962845077P 2019-05-08 2019-05-08
PCT/US2020/016182 WO2020160453A1 (en) 2019-01-31 2020-01-31 Modulators of yap1 expression

Publications (1)

Publication Number Publication Date
MX2021008918A true MX2021008918A (es) 2021-08-24

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ID=71841675

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MX2021008918A MX2021008918A (es) 2019-01-31 2020-01-31 Moduladores de expresion yap1.

Country Status (13)

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US (2) US11214803B2 (es)
EP (1) EP3917540A1 (es)
JP (1) JP2022519532A (es)
KR (1) KR20210122809A (es)
CN (1) CN113395971A (es)
AU (1) AU2020216444A1 (es)
BR (1) BR112021013369A2 (es)
CA (1) CA3128093A1 (es)
IL (1) IL284761A (es)
MX (1) MX2021008918A (es)
SG (1) SG11202107399WA (es)
TW (1) TW202214854A (es)
WO (1) WO2020160453A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114410633B (zh) * 2022-02-14 2024-06-25 天津市泌尿外科研究所 反义寡核苷酸asoyap1在抑制多种yap1阳性癌症中的应用
KR102671551B1 (ko) * 2022-03-11 2024-06-03 주식회사 파이안바이오테크놀로지 전구약물 전환 효소를 포함하는 개질된 미토콘드리아 및 이의 용도
WO2025131123A1 (zh) * 2023-12-21 2025-06-26 北京哲源科技有限责任公司 一种并环化合物的应用
WO2026006655A1 (en) * 2024-06-28 2026-01-02 University Of Florida Research Foundation, Incorporated Combination of yap protacs and sorafenib for use in the treatment of cancer

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