MX2021004741A - Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo. - Google Patents
Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo.Info
- Publication number
- MX2021004741A MX2021004741A MX2021004741A MX2021004741A MX2021004741A MX 2021004741 A MX2021004741 A MX 2021004741A MX 2021004741 A MX2021004741 A MX 2021004741A MX 2021004741 A MX2021004741 A MX 2021004741A MX 2021004741 A MX2021004741 A MX 2021004741A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- same
- aminopeptidase
- inhibitors
- pharmaceutical compositions
- Prior art date
Links
- 102000006485 Glutamyl Aminopeptidase Human genes 0.000 title 1
- 108010058940 Glutamyl Aminopeptidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65306—Five-membered rings containing two nitrogen atoms
- C07F9/65312—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención actual se refiere a un nuevo compuesto, a una composición que lo comprende, a métodos para preparar el compuesto y al uso de este compuesto en terapia. En particular, la invención actual se refiere a un compuesto que es útil en el tratamiento y prevención de hipertensión arterial primaria y secundaria, accidente cerebrovascular, isquemia miocárdica, insuficiencia cardíaca y renal, infarto de miocardio, enfermedad vascular periférica, proteinuria diabética, síndrome X y glaucoma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306396 | 2018-10-26 | ||
| PCT/EP2019/079229 WO2020084131A1 (en) | 2018-10-26 | 2019-10-25 | Aminopeptidase a inhibitors and pharmaceutical compositions comprising the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2021004741A true MX2021004741A (es) | 2022-03-16 |
| MX390718B MX390718B (es) | 2025-03-21 |
Family
ID=64267736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021004741A MX390718B (es) | 2018-10-26 | 2019-10-25 | Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11192907B2 (es) |
| EP (1) | EP3870591A1 (es) |
| JP (1) | JP7051009B2 (es) |
| KR (1) | KR102380042B1 (es) |
| CN (1) | CN113166182A (es) |
| AR (1) | AR116853A1 (es) |
| AU (1) | AU2019365119B2 (es) |
| BR (1) | BR112021007116A2 (es) |
| CA (1) | CA3112851C (es) |
| EA (1) | EA202191150A1 (es) |
| IL (1) | IL282591B (es) |
| MX (1) | MX390718B (es) |
| TW (1) | TW202029962A (es) |
| WO (1) | WO2020084131A1 (es) |
| ZA (1) | ZA202103580B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202191151A1 (ru) * | 2018-10-26 | 2021-07-15 | Квантум Дженомикс | Новые аминофосфиновые производные в качестве ингибиторов аминопептидазы а |
| TW202207917A (zh) * | 2020-05-06 | 2022-03-01 | 法商量子基因科技有限公司 | 包含腦胺肽酶抑制劑、利尿劑及全身性腎素－血管收縮素系統阻斷劑之醫藥組合物 |
| CN115385789B (zh) * | 2022-09-19 | 2024-06-04 | 安徽大学 | 一种4-氧代丁酸甲酯的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773712B1 (fr) * | 1998-01-16 | 2000-06-02 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a |
| ES2369256T3 (es) * | 2000-06-26 | 2011-11-28 | Helen Of Troy Limited | Sistema de lámpara recargable. |
| AR058296A1 (es) * | 2005-12-09 | 2008-01-30 | Kalypsys Inc | Inhibidores de histona desacetilasa y composicion farmaceutica |
| US20080146524A1 (en) | 2006-12-14 | 2008-06-19 | Solvay Pharmaceuticals B.V. | Selective inhibitors of neurotensin degrading enzymes |
| FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| EA202191151A1 (ru) | 2018-10-26 | 2021-07-15 | Квантум Дженомикс | Новые аминофосфиновые производные в качестве ингибиторов аминопептидазы а |
-
2019
- 2019-10-23 TW TW108138218A patent/TW202029962A/zh unknown
- 2019-10-25 CA CA3112851A patent/CA3112851C/en active Active
- 2019-10-25 JP JP2021523669A patent/JP7051009B2/ja not_active Expired - Fee Related
- 2019-10-25 IL IL282591A patent/IL282591B/en unknown
- 2019-10-25 AR ARP190103083A patent/AR116853A1/es not_active Application Discontinuation
- 2019-10-25 EP EP19790023.6A patent/EP3870591A1/en not_active Withdrawn
- 2019-10-25 MX MX2021004741A patent/MX390718B/es unknown
- 2019-10-25 US US17/288,516 patent/US11192907B2/en not_active Expired - Fee Related
- 2019-10-25 KR KR1020217015043A patent/KR102380042B1/ko not_active Expired - Fee Related
- 2019-10-25 CN CN201980070944.7A patent/CN113166182A/zh active Pending
- 2019-10-25 WO PCT/EP2019/079229 patent/WO2020084131A1/en not_active Ceased
- 2019-10-25 AU AU2019365119A patent/AU2019365119B2/en not_active Ceased
- 2019-10-25 BR BR112021007116-4A patent/BR112021007116A2/pt not_active Application Discontinuation
- 2019-10-25 EA EA202191150A patent/EA202191150A1/ru unknown
-
2021
- 2021-05-26 ZA ZA2021/03580A patent/ZA202103580B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11192907B2 (en) | 2021-12-07 |
| IL282591B (en) | 2022-08-01 |
| KR102380042B1 (ko) | 2022-03-28 |
| EP3870591A1 (en) | 2021-09-01 |
| AU2019365119B2 (en) | 2021-07-29 |
| MX390718B (es) | 2025-03-21 |
| EA202191150A1 (ru) | 2021-07-15 |
| BR112021007116A2 (pt) | 2021-07-20 |
| AU2019365119A1 (en) | 2021-04-15 |
| JP7051009B2 (ja) | 2022-04-08 |
| WO2020084131A1 (en) | 2020-04-30 |
| KR20210079336A (ko) | 2021-06-29 |
| US20210309678A1 (en) | 2021-10-07 |
| CA3112851C (en) | 2023-01-24 |
| CA3112851A1 (en) | 2020-04-30 |
| AR116853A1 (es) | 2021-06-23 |
| IL282591A (en) | 2021-06-30 |
| JP2021535189A (ja) | 2021-12-16 |
| TW202029962A (zh) | 2020-08-16 |
| ZA202103580B (en) | 2022-08-31 |
| CN113166182A (zh) | 2021-07-23 |
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