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MX2021000411A - Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico. - Google Patents

Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico.

Info

Publication number
MX2021000411A
MX2021000411A MX2021000411A MX2021000411A MX2021000411A MX 2021000411 A MX2021000411 A MX 2021000411A MX 2021000411 A MX2021000411 A MX 2021000411A MX 2021000411 A MX2021000411 A MX 2021000411A MX 2021000411 A MX2021000411 A MX 2021000411A
Authority
MX
Mexico
Prior art keywords
prostamide
ophthalmic compositions
compositions containing
nitric oxide
oxide releasing
Prior art date
Application number
MX2021000411A
Other languages
English (en)
Inventor
Frédéric Pilotaz
Alan L Weiner
Marina Do
Julien Saldo
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of MX2021000411A publication Critical patent/MX2021000411A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composiciones oftálmicas acuosas en forma de soluciones que comprenden éster (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(etilamino)-7- oxo-2-hepten-1-il]-3,5-dihidroxiciclopentil]-1-(2-feniletil)-2-pr open-1-ílico de ácido 6-(nitrooxi)hexanoico y 15-hidroxiestearato de macrogol como único agente solubilizante. Método para prepararlas.
MX2021000411A 2018-07-12 2019-07-10 Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico. MX2021000411A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18290082 2018-07-12
PCT/EP2019/068511 WO2020011845A1 (en) 2018-07-12 2019-07-10 Ophthalmic compositions containing a nitric oxide releasing prostamide

Publications (1)

Publication Number Publication Date
MX2021000411A true MX2021000411A (es) 2021-03-25

Family

ID=63012964

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021000411A MX2021000411A (es) 2018-07-12 2019-07-10 Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico.
MX2023007091A MX2023007091A (es) 2018-07-12 2021-01-11 Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023007091A MX2023007091A (es) 2018-07-12 2021-01-11 Composiciones oftalmicas que contienen una prostamida liberadora de oxido nitrico.

Country Status (28)

Country Link
US (5) US10688073B2 (es)
EP (2) EP3593788B1 (es)
JP (4) JP6672512B2 (es)
KR (1) KR102861273B1 (es)
CN (2) CN111249228B (es)
AR (1) AR115734A1 (es)
AU (2) AU2019300203B2 (es)
BR (1) BR112021000240A2 (es)
CA (1) CA3105989A1 (es)
CY (1) CY1123706T1 (es)
DK (1) DK3593788T3 (es)
ES (2) ES2847853T3 (es)
HR (2) HRP20251098T1 (es)
HU (2) HUE052747T2 (es)
LT (1) LT3593788T (es)
MA (2) MA52258B1 (es)
MD (2) MD3593788T2 (es)
MX (2) MX2021000411A (es)
MY (1) MY205816A (es)
PH (1) PH12020552112A1 (es)
PL (2) PL3593788T3 (es)
PT (1) PT3593788T (es)
RS (2) RS61348B1 (es)
SG (1) SG11202100064WA (es)
SI (1) SI3593788T1 (es)
SM (2) SMT202500425T1 (es)
TW (1) TWI839364B (es)
WO (1) WO2020011845A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3593788B1 (en) * 2018-07-12 2020-10-28 Nicox S.A. Ophthalmic compositions containing a nitric oxide releasing prostamide
US20240390390A1 (en) * 2021-09-20 2024-11-28 Nicox Sa Nitric oxide releasing prostamide as neuroprotective agent
JP7665073B1 (ja) 2024-04-05 2025-04-18 ロート製薬株式会社 容器に収容してなる眼科用組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2918891B1 (fr) * 2007-07-20 2009-09-25 Thea Sa Lab Solution ophtalmique a base de prostaglandines sans conservateur
MX2010004211A (es) * 2007-10-16 2010-06-30 Sun Pharma Advanced Res Co Ltd Composicion oftalmica que comprende una prostaglandina.
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
GB2463565A (en) 2008-09-12 2010-03-24 Critical Pharmaceuticals Ltd Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
EP2566453A4 (en) * 2010-05-07 2014-05-07 Sun Pharma Advanced Res Co Ltd NOVEL OPHTHALMIC COMPOSITIONS
FR2961694B1 (fr) 2010-06-29 2013-01-25 Thea Lab Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur
JP2014522849A (ja) * 2011-06-29 2014-09-08 アラーガン インコーポレイテッド ヒドロキシステアリン酸マクロゴール15製剤
AU2012291841A1 (en) 2011-08-02 2014-02-06 Cipla Limited Pharmaceutical composition comprising ebastine and fluticasone
CN105012231A (zh) * 2014-04-30 2015-11-04 四川科伦药物研究院有限公司 一种包含PGF2α衍生物的稳定性良好的眼用制剂及其制备方法
CN105380901B (zh) * 2015-11-18 2018-07-17 侯宇华 一种他氟前列素滴眼剂及其制备方法
EP3593788B1 (en) * 2018-07-12 2020-10-28 Nicox S.A. Ophthalmic compositions containing a nitric oxide releasing prostamide

Also Published As

Publication number Publication date
HRP20210138T1 (hr) 2021-03-19
PH12020552112A1 (en) 2021-05-31
LT3593788T (lt) 2021-04-12
MA52258A (fr) 2021-02-17
RS61348B1 (sr) 2021-02-26
ES2847853T3 (es) 2021-08-04
RS67054B1 (sr) 2025-08-29
SI3593788T1 (sl) 2021-03-31
US20200016108A1 (en) 2020-01-16
AU2019300203B2 (en) 2025-01-30
MX2023007091A (es) 2023-06-27
CA3105989A1 (en) 2020-01-16
PT3593788T (pt) 2021-01-21
TW202019401A (zh) 2020-06-01
KR20210032435A (ko) 2021-03-24
US10688073B2 (en) 2020-06-23
EP3593788A1 (en) 2020-01-15
HUE072927T2 (hu) 2025-12-28
MD3718535T2 (ro) 2025-08-31
AU2025203019A1 (en) 2025-05-15
CN110237031A (zh) 2019-09-17
DK3593788T3 (da) 2021-01-11
MA52258B1 (fr) 2025-07-31
US12178793B2 (en) 2024-12-31
AU2019300203A1 (en) 2021-03-04
US11020368B2 (en) 2021-06-01
US20210220316A1 (en) 2021-07-22
TWI839364B (zh) 2024-04-21
US20200206176A1 (en) 2020-07-02
US20250073196A1 (en) 2025-03-06
WO2020011845A1 (en) 2020-01-16
KR102861273B1 (ko) 2025-09-17
BR112021000240A2 (pt) 2021-04-06
PL3593788T3 (pl) 2021-05-31
CY1123706T1 (el) 2022-05-27
HUE052747T2 (hu) 2021-05-28
JP7397910B2 (ja) 2023-12-13
US20210128458A1 (en) 2021-05-06
SG11202100064WA (en) 2021-02-25
PL3718535T3 (pl) 2025-10-13
US12186295B2 (en) 2025-01-07
JP2024023498A (ja) 2024-02-21
EP3593788B1 (en) 2020-10-28
EP3718535C0 (en) 2025-06-18
JP6672512B2 (ja) 2020-03-25
MY205816A (en) 2024-11-14
JP2022116147A (ja) 2022-08-09
SMT202100034T1 (it) 2021-03-15
EP3718535A1 (en) 2020-10-07
ES3036636T3 (en) 2025-09-23
CN111249228A (zh) 2020-06-09
MD3593788T2 (ro) 2021-03-31
MA48919A (fr) 2020-01-15
EP3718535B1 (en) 2025-06-18
MA48919B1 (fr) 2021-02-26
JP7080268B2 (ja) 2022-06-03
JP2020105201A (ja) 2020-07-09
AR115734A1 (es) 2021-02-17
CN110237031B (zh) 2022-02-11
JP2020011955A (ja) 2020-01-23
SMT202500425T1 (it) 2026-01-12
CN111249228B (zh) 2022-05-03
HRP20251098T1 (hr) 2025-11-07

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