MX2021000469A - Inhibidores biciclicos de las histona desacetilasas. - Google Patents
Inhibidores biciclicos de las histona desacetilasas.Info
- Publication number
- MX2021000469A MX2021000469A MX2021000469A MX2021000469A MX2021000469A MX 2021000469 A MX2021000469 A MX 2021000469A MX 2021000469 A MX2021000469 A MX 2021000469A MX 2021000469 A MX2021000469 A MX 2021000469A MX 2021000469 A MX2021000469 A MX 2021000469A
- Authority
- MX
- Mexico
- Prior art keywords
- histone deacetylase
- bicyclic inhibitors
- bicyclic
- inhibitors
- hdac
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title abstract 3
- 108090000353 Histone deacetylase Proteins 0.000 title abstract 3
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos de la fórmula I: (ver Fórmula) y sales farmacéuticamente aceptables y composiciones con el mismo, que son de utilidad para tratar una variedad de condiciones asociadas con las histona desacetilasas (HDAC).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697497P | 2018-07-13 | 2018-07-13 | |
| PCT/US2019/041587 WO2020014602A1 (en) | 2018-07-13 | 2019-07-12 | Bicyclic inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021000469A true MX2021000469A (es) | 2021-06-23 |
Family
ID=67480367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021000469A MX2021000469A (es) | 2018-07-13 | 2019-07-12 | Inhibidores biciclicos de las histona desacetilasas. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210276977A1 (es) |
| EP (1) | EP3820863A1 (es) |
| JP (2) | JP7381578B2 (es) |
| KR (1) | KR20210031703A (es) |
| CN (1) | CN112805275A (es) |
| AR (1) | AR115770A1 (es) |
| AU (1) | AU2019301761A1 (es) |
| CA (1) | CA3106354A1 (es) |
| EA (1) | EA202190070A1 (es) |
| IL (2) | IL279920B2 (es) |
| MA (1) | MA53128A (es) |
| MX (1) | MX2021000469A (es) |
| SG (1) | SG11202012918PA (es) |
| TW (1) | TW202019910A (es) |
| WO (1) | WO2020014602A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180194769A1 (en) | 2015-07-06 | 2018-07-12 | Rodin Therapeutics, Inc. | Hetero-halo inhibitors of histone deacetylase |
| DK3570834T3 (en) | 2017-01-11 | 2022-02-28 | Alkermes Inc | Bicyclic inhibitors of histone deacetylase |
| AU2018313094A1 (en) | 2017-08-07 | 2020-02-20 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| WO2023102162A1 (en) | 2021-12-03 | 2023-06-08 | Tango Therapeutics, Inc. | Tgonovel hdac inhibitors and therapeutic use thereof |
| CN115243023B (zh) * | 2022-07-20 | 2025-02-07 | 展讯通信（上海）有限公司 | 一种图像处理方法、装置、电子设备及存储介质 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101808518A (zh) * | 2007-06-27 | 2010-08-18 | 默沙东公司 | 作为组蛋白脱乙酰酶抑制剂的吡啶基和嘧啶基衍生物 |
| WO2012149540A1 (en) * | 2011-04-28 | 2012-11-01 | The Broad Institute Inc | Inhibitors of histone deacetylase |
| WO2016018795A1 (en) | 2014-07-28 | 2016-02-04 | The General Hospital Corporation | Histone deacetylase inhibitors |
| US20180194769A1 (en) | 2015-07-06 | 2018-07-12 | Rodin Therapeutics, Inc. | Hetero-halo inhibitors of histone deacetylase |
-
2019
- 2019-07-12 AR ARP190101974A patent/AR115770A1/es not_active Application Discontinuation
- 2019-07-12 EA EA202190070A patent/EA202190070A1/ru unknown
- 2019-07-12 TW TW108124684A patent/TW202019910A/zh unknown
- 2019-07-12 AU AU2019301761A patent/AU2019301761A1/en not_active Abandoned
- 2019-07-12 JP JP2021523577A patent/JP7381578B2/ja active Active
- 2019-07-12 IL IL279920A patent/IL279920B2/en unknown
- 2019-07-12 CN CN201980046528.3A patent/CN112805275A/zh active Pending
- 2019-07-12 WO PCT/US2019/041587 patent/WO2020014602A1/en not_active Ceased
- 2019-07-12 IL IL310297A patent/IL310297A/en unknown
- 2019-07-12 MA MA053128A patent/MA53128A/fr unknown
- 2019-07-12 KR KR1020217002883A patent/KR20210031703A/ko not_active Withdrawn
- 2019-07-12 US US17/260,192 patent/US20210276977A1/en not_active Abandoned
- 2019-07-12 MX MX2021000469A patent/MX2021000469A/es unknown
- 2019-07-12 SG SG11202012918PA patent/SG11202012918PA/en unknown
- 2019-07-12 EP EP19746298.9A patent/EP3820863A1/en not_active Withdrawn
- 2019-07-12 CA CA3106354A patent/CA3106354A1/en active Pending
-
2023
- 2023-11-01 JP JP2023187395A patent/JP2024012457A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MA53128A (fr) | 2021-05-19 |
| CA3106354A1 (en) | 2020-01-16 |
| IL279920A (en) | 2021-03-01 |
| AR115770A1 (es) | 2021-02-24 |
| CN112805275A (zh) | 2021-05-14 |
| IL310297A (en) | 2024-03-01 |
| WO2020014602A1 (en) | 2020-01-16 |
| SG11202012918PA (en) | 2021-02-25 |
| TW202019910A (zh) | 2020-06-01 |
| EA202190070A1 (ru) | 2021-10-26 |
| KR20210031703A (ko) | 2021-03-22 |
| EP3820863A1 (en) | 2021-05-19 |
| JP2021531335A (ja) | 2021-11-18 |
| AU2019301761A1 (en) | 2021-01-14 |
| IL279920B1 (en) | 2024-02-01 |
| JP7381578B2 (ja) | 2023-11-15 |
| US20210276977A1 (en) | 2021-09-09 |
| JP2024012457A (ja) | 2024-01-30 |
| IL279920B2 (en) | 2024-06-01 |
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