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MX2021000322A - Enzimas de variante fosfopentomutasa modificada geneticamente. - Google Patents

Enzimas de variante fosfopentomutasa modificada geneticamente.

Info

Publication number
MX2021000322A
MX2021000322A MX2021000322A MX2021000322A MX2021000322A MX 2021000322 A MX2021000322 A MX 2021000322A MX 2021000322 A MX2021000322 A MX 2021000322A MX 2021000322 A MX2021000322 A MX 2021000322A MX 2021000322 A MX2021000322 A MX 2021000322A
Authority
MX
Mexico
Prior art keywords
enzymes
genetically modified
ppm
present
variant enzymes
Prior art date
Application number
MX2021000322A
Other languages
English (en)
Inventor
Jeffrey C Moore
Vesna Mitchell
Nikki Dellas
Oscar Alvizo
Jonathan Vroom
Xiang Yi
Da Duan
Scott J Novick
Jovana Nazor
Santhosh Sivaramakrishnan
Nandhitha Subramanian
Mark Huffman
Agustina Rodriguez-Granillo
Deeptak Verma
Grant Murphy
Nicholas M Marshall
Jay Russell
Canada Keith A
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of MX2021000322A publication Critical patent/MX2021000322A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02007—Phosphopentomutase (5.4.2.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona enzimas fosfopentomutasa (PPM) modificadas genéticamente, polipéptidos que tienen actividad de PPM y polinucleótidos que codifican estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; también se proporcionan métodos para producir enzimas PPM; la presente invención proporciona además composiciones que comprenden las enzimas PPM y métodos para usar las enzimas PPM modificadas genéticamente; la presente invención encuentra un uso particular en la producción de compuestos farmacéuticos.
MX2021000322A 2018-07-09 2019-07-02 Enzimas de variante fosfopentomutasa modificada geneticamente. MX2021000322A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862695491P 2018-07-09 2018-07-09
PCT/US2019/040353 WO2020014046A1 (en) 2018-07-09 2019-07-02 Engineered phosphopentomutase variant enzymes

Publications (1)

Publication Number Publication Date
MX2021000322A true MX2021000322A (es) 2021-03-25

Family

ID=69101520

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021000322A MX2021000322A (es) 2018-07-09 2019-07-02 Enzimas de variante fosfopentomutasa modificada geneticamente.

Country Status (11)

Country Link
US (4) US11034948B2 (es)
EP (1) EP3821026A4 (es)
JP (2) JP7493248B2 (es)
KR (1) KR20210031933A (es)
CN (1) CN112601821A (es)
AU (1) AU2019302422B2 (es)
CA (1) CA3108728A1 (es)
IL (1) IL279880B1 (es)
MX (1) MX2021000322A (es)
SG (1) SG11202012109UA (es)
WO (1) WO2020014046A1 (es)

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JP7773906B2 (ja) 2018-07-09 2025-11-20 メルク・シャープ・アンド・ドーム・エルエルシー ４’－エチルヌクレオシド類似体の酵素的合成
AU2019302422B2 (en) 2018-07-09 2022-08-04 Codexis, Inc. Engineered phosphopentomutase variant enzymes
US12480104B2 (en) 2019-07-02 2025-11-25 Codexis, Inc. Engineered sucrose phosphorylase variant enzymes
AU2021358938A1 (en) * 2020-10-07 2023-04-27 Codexis, Inc. Engineered phosphopentomutase variant enzymes
JP2024500102A (ja) * 2020-12-18 2024-01-04 コデクシス， インコーポレイテッド 操作されたウリジンホスホリラーゼ改変体酵素
CN116855471B (zh) * 2023-09-04 2023-11-28 江苏申基生物科技有限公司 一种嘌呤核苷磷酸化酶突变体及其应用

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Also Published As

Publication number Publication date
JP2024040366A (ja) 2024-03-25
US20200010823A1 (en) 2020-01-09
IL279880A (en) 2021-03-01
CN112601821A (zh) 2021-04-02
US20240060064A1 (en) 2024-02-22
KR20210031933A (ko) 2021-03-23
CA3108728A1 (en) 2020-01-16
US20210261940A1 (en) 2021-08-26
US12421509B2 (en) 2025-09-23
US20260009012A1 (en) 2026-01-08
SG11202012109UA (en) 2021-01-28
EP3821026A1 (en) 2021-05-19
AU2019302422B2 (en) 2022-08-04
US11795445B2 (en) 2023-10-24
WO2020014046A1 (en) 2020-01-16
JP7493248B2 (ja) 2024-05-31
IL279880B1 (en) 2025-11-01
JP2021530981A (ja) 2021-11-18
US11034948B2 (en) 2021-06-15
EP3821026A4 (en) 2022-06-01
AU2019302422A1 (en) 2021-01-07

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