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MX2020014098A - Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington. - Google Patents

Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington.

Info

Publication number
MX2020014098A
MX2020014098A MX2020014098A MX2020014098A MX2020014098A MX 2020014098 A MX2020014098 A MX 2020014098A MX 2020014098 A MX2020014098 A MX 2020014098A MX 2020014098 A MX2020014098 A MX 2020014098A MX 2020014098 A MX2020014098 A MX 2020014098A
Authority
MX
Mexico
Prior art keywords
disease
compounds
heterocyclic
forms
heteroaryl compounds
Prior art date
Application number
MX2020014098A
Other languages
English (en)
Inventor
Aleksey I Gerasyuto
Matthew G Woll
Guangming Chen
Jana Narasimhan
Nanjing Zhang
Gary Mitchell Karp
Nadiya Sydorenko
Suresh Babu
Anuradha Bhattacharyya
Anthony R Mazzotti
Jigar Patel
Anthony Turpoff
Young-Choon Moon
Md Rauful Alam
Michael A Arnold
Andrew J Kassick
Wuming Yan
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of MX2020014098A publication Critical patent/MX2020014098A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se refiere a compuestos heterocíclicos y de heteroarilo sustituidos de Fórmula (I), formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.
MX2020014098A 2018-06-27 2019-06-25 Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington. MX2020014098A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862690653P 2018-06-27 2018-06-27
PCT/US2019/038889 WO2020005873A1 (en) 2018-06-27 2019-06-25 Heterocyclic and heteroaryl compounds for treating huntington's disease

Publications (1)

Publication Number Publication Date
MX2020014098A true MX2020014098A (es) 2021-05-27

Family

ID=67180896

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020014098A MX2020014098A (es) 2018-06-27 2019-06-25 Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington.

Country Status (30)

Country Link
US (2) US11858941B2 (es)
EP (2) EP4434990A1 (es)
JP (1) JP7421507B2 (es)
KR (1) KR102823158B1 (es)
CN (1) CN112654625B (es)
AR (1) AR119651A1 (es)
AU (2) AU2019294478B2 (es)
BR (1) BR112020026545A2 (es)
CA (1) CA3103976A1 (es)
CL (3) CL2020003378A1 (es)
CO (1) CO2020016285A2 (es)
DK (1) DK3814357T3 (es)
EA (1) EA202092896A1 (es)
ES (1) ES2983003T3 (es)
FI (1) FI3814357T3 (es)
HR (1) HRP20240935T1 (es)
HU (1) HUE068060T2 (es)
IL (1) IL279688B2 (es)
LT (1) LT3814357T (es)
MX (1) MX2020014098A (es)
PE (1) PE20211378A1 (es)
PL (1) PL3814357T3 (es)
PT (1) PT3814357T (es)
RS (1) RS65727B1 (es)
SG (1) SG11202012674PA (es)
SI (1) SI3814357T1 (es)
SM (1) SMT202400286T1 (es)
UA (1) UA129258C2 (es)
WO (1) WO2020005873A1 (es)
ZA (1) ZA202100208B (es)

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CL2021003022A1 (es) 2022-07-01
AU2019294478B2 (en) 2023-03-23
AU2023203241B2 (en) 2025-01-02
PL3814357T3 (pl) 2024-09-16
US20210238186A1 (en) 2021-08-05
SMT202400286T1 (it) 2024-09-16
IL279688B1 (en) 2024-09-01
KR102823158B1 (ko) 2025-06-20
SI3814357T1 (sl) 2024-09-30
CL2022003434A1 (es) 2023-06-02
EP3814357B1 (en) 2024-05-01
KR20210042265A (ko) 2021-04-19
WO2020005873A1 (en) 2020-01-02
ZA202100208B (en) 2025-05-28
US20260028347A1 (en) 2026-01-29

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