MX2020013694A - Compuestos heterocíclicos como inhibidores de trk. - Google Patents
Compuestos heterocíclicos como inhibidores de trk.Info
- Publication number
- MX2020013694A MX2020013694A MX2020013694A MX2020013694A MX2020013694A MX 2020013694 A MX2020013694 A MX 2020013694A MX 2020013694 A MX2020013694 A MX 2020013694A MX 2020013694 A MX2020013694 A MX 2020013694A MX 2020013694 A MX2020013694 A MX 2020013694A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- trk inhibitor
- heterocyclic compound
- trk
- treating
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000155 isotopic effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a un compuesto, una composición farmacéutica que comprende el compuesto, el método para la preparación del mismo, y el uso del mismo como inhibidor de TRK; el compuesto es un compuesto mostrado en la fórmula I siguiente, e isómeros, profármacos, solvatos, derivados isotópicos estables o sales farmacéuticamente aceptables de los mismos; la presente invención también se refiere al uso del compuesto en el tratamiento o prevención de enfermedades mediadas por TRK, tales como cánceres, y métodos para el tratamiento de tales enfermedades usando los compuestos de la presente invención. (ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810660162.6A CN110627812B (zh) | 2018-06-25 | 2018-06-25 | 作为trk抑制剂的杂环化合物 |
| PCT/CN2019/092653 WO2020001415A1 (zh) | 2018-06-25 | 2019-06-25 | 作为trk抑制剂的杂环化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020013694A true MX2020013694A (es) | 2021-05-27 |
Family
ID=68966871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020013694A MX2020013694A (es) | 2018-06-25 | 2019-06-25 | Compuestos heterocíclicos como inhibidores de trk. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11878987B2 (es) |
| EP (1) | EP3822276B1 (es) |
| JP (1) | JP7372686B2 (es) |
| KR (1) | KR102798429B1 (es) |
| CN (1) | CN110627812B (es) |
| AU (1) | AU2019296085B2 (es) |
| BR (1) | BR112020026653A2 (es) |
| CA (1) | CA3104377C (es) |
| MX (1) | MX2020013694A (es) |
| PH (1) | PH12020552244A1 (es) |
| SG (1) | SG11202013016YA (es) |
| TW (1) | TWI828712B (es) |
| WO (1) | WO2020001415A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7092405B2 (ja) | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| CN110627812B (zh) | 2018-06-25 | 2022-10-11 | 北京诺诚健华医药科技有限公司 | 作为trk抑制剂的杂环化合物 |
| WO2021042890A1 (zh) * | 2019-09-04 | 2021-03-11 | 罗欣药业(上海)有限公司 | 杂环化合物及其作为Trk激酶抑制剂的应用 |
| CN115884776B (zh) * | 2021-06-15 | 2024-07-23 | 中国医药研究开发中心有限公司 | 杂环大环化合物及其医药用途 |
| CN113444070A (zh) * | 2021-07-28 | 2021-09-28 | 深圳市真味生物科技有限公司 | 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法 |
| CN113754657B (zh) * | 2021-09-22 | 2023-01-17 | 广州白云山医药集团股份有限公司白云山制药总厂 | 大环类化合物的晶型及其制备方法和应用 |
| CN116554203A (zh) | 2022-01-29 | 2023-08-08 | 南京天印健华医药科技有限公司 | 化合物的晶型及其制备方法 |
| CN117586277A (zh) * | 2022-08-09 | 2024-02-23 | 苏州朗睿生物医药有限公司 | 一种大环三氮唑衍生物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3372605T (pt) * | 2008-10-22 | 2021-12-09 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| SMT201900203T1 (it) * | 2010-05-20 | 2019-05-10 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| CN104023728B (zh) | 2011-09-30 | 2016-11-02 | 益普生制药股份有限公司 | 大环lrrk2激酶抑制剂 |
| PL3097107T3 (pl) | 2014-01-24 | 2020-01-31 | Turning Point Therapeutics, Inc. | Diarylowe związki makrocykliczne jako modulatory kinaz białkowych |
| CA3003153A1 (en) * | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| WO2019094143A1 (en) * | 2017-11-10 | 2019-05-16 | Angex Pharmaceutical, Inc. | Macrocyclic compounds as trk kinase inhibitors and uses thereof |
| TW201932472A (zh) | 2018-01-30 | 2019-08-16 | 大陸商上海吉倍生物技術有限公司 | 具有大環分子結構的化合物及其用途 |
| CN110156813B (zh) | 2018-02-13 | 2023-07-25 | 北京诺诚健华医药科技有限公司 | 作为trk抑制剂的杂环化合物 |
| JP7092405B2 (ja) * | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| CN110627812B (zh) | 2018-06-25 | 2022-10-11 | 北京诺诚健华医药科技有限公司 | 作为trk抑制剂的杂环化合物 |
-
2018
- 2018-06-25 CN CN201810660162.6A patent/CN110627812B/zh active Active
-
2019
- 2019-06-25 TW TW108122091A patent/TWI828712B/zh active
- 2019-06-25 BR BR112020026653-1A patent/BR112020026653A2/pt unknown
- 2019-06-25 CA CA3104377A patent/CA3104377C/en active Active
- 2019-06-25 SG SG11202013016YA patent/SG11202013016YA/en unknown
- 2019-06-25 WO PCT/CN2019/092653 patent/WO2020001415A1/zh not_active Ceased
- 2019-06-25 MX MX2020013694A patent/MX2020013694A/es unknown
- 2019-06-25 EP EP19825716.4A patent/EP3822276B1/en active Active
- 2019-06-25 US US17/255,797 patent/US11878987B2/en active Active
- 2019-06-25 AU AU2019296085A patent/AU2019296085B2/en active Active
- 2019-06-25 KR KR1020217001867A patent/KR102798429B1/ko active Active
- 2019-06-25 JP JP2020572445A patent/JP7372686B2/ja active Active
-
2020
- 2020-12-22 PH PH12020552244A patent/PH12020552244A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11878987B2 (en) | 2024-01-23 |
| BR112020026653A2 (pt) | 2021-03-23 |
| AU2019296085A1 (en) | 2021-01-28 |
| TWI828712B (zh) | 2024-01-11 |
| JP7372686B2 (ja) | 2023-11-01 |
| AU2019296085B2 (en) | 2024-02-15 |
| KR102798429B1 (ko) | 2025-04-22 |
| KR20210024043A (ko) | 2021-03-04 |
| JP2021529182A (ja) | 2021-10-28 |
| CA3104377A1 (en) | 2020-01-02 |
| US20210147445A1 (en) | 2021-05-20 |
| TW202019939A (zh) | 2020-06-01 |
| EP3822276B1 (en) | 2026-01-28 |
| SG11202013016YA (en) | 2021-02-25 |
| PH12020552244A1 (en) | 2021-06-28 |
| CN110627812A (zh) | 2019-12-31 |
| WO2020001415A1 (zh) | 2020-01-02 |
| EP3822276A4 (en) | 2022-04-06 |
| CA3104377C (en) | 2024-01-23 |
| EP3822276A1 (en) | 2021-05-19 |
| CN110627812B (zh) | 2022-10-11 |
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