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MX2020013104A - Agentes activos y metodos de uso para el tratamiento de trastornos metabolicos y enfermedad hepatica no alcoholica. - Google Patents

Agentes activos y metodos de uso para el tratamiento de trastornos metabolicos y enfermedad hepatica no alcoholica.

Info

Publication number
MX2020013104A
MX2020013104A MX2020013104A MX2020013104A MX2020013104A MX 2020013104 A MX2020013104 A MX 2020013104A MX 2020013104 A MX2020013104 A MX 2020013104A MX 2020013104 A MX2020013104 A MX 2020013104A MX 2020013104 A MX2020013104 A MX 2020013104A
Authority
MX
Mexico
Prior art keywords
liver disease
fatty liver
methods
active agents
treatment
Prior art date
Application number
MX2020013104A
Other languages
English (en)
Inventor
John Robert Proudfoot
David Arthur Berry
Timothy F Briggs
Steven John Taylor
Mi - Jeong Kim
Kathleen Nudel
Sarvestani Afrand Kamali
Leonard Buckbinder
Bernard Lanter
Ferdinand Edward Massari
Koji Yasuda
Spencer Cory Peck
Cheri Snedeker
Diana Le
Jessica Alexander
Anna Liang
Dinara Gunasekera
John Patrick Casey Jr
Original Assignee
Flagship Pioneering Innovations V Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations V Inc filed Critical Flagship Pioneering Innovations V Inc
Publication of MX2020013104A publication Critical patent/MX2020013104A/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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Abstract

En la presente descripción se describen agentes activos, composiciones que los contienen, formas de dosificación unitaria que los contienen, y métodos de su uso, por ejemplo, para tratar un trastorno metabólico o una enfermedad del hígado graso no alcohólica o para modular un marcador metabólico o un marcador de enfermedad del hígado graso no alcohólica.
MX2020013104A 2018-06-05 2019-06-05 Agentes activos y metodos de uso para el tratamiento de trastornos metabolicos y enfermedad hepatica no alcoholica. MX2020013104A (es)

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US201862680976P 2018-06-05 2018-06-05
US201862680977P 2018-06-05 2018-06-05
US201862776448P 2018-12-06 2018-12-06
US201862776455P 2018-12-06 2018-12-06
US201962828958P 2019-04-03 2019-04-03
PCT/US2019/035680 WO2019236775A1 (en) 2018-06-05 2019-06-05 Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease

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US11813272B2 (en) 2023-11-14
BR112020024695A2 (pt) 2021-03-02
US20200197428A1 (en) 2020-06-25
WO2019236775A1 (en) 2019-12-12
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