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MX2020012629A - Metodo para sintesis de peptido en fase de solucion y estrategias protectoras de la misma. - Google Patents

Metodo para sintesis de peptido en fase de solucion y estrategias protectoras de la misma.

Info

Publication number
MX2020012629A
MX2020012629A MX2020012629A MX2020012629A MX2020012629A MX 2020012629 A MX2020012629 A MX 2020012629A MX 2020012629 A MX2020012629 A MX 2020012629A MX 2020012629 A MX2020012629 A MX 2020012629A MX 2020012629 A MX2020012629 A MX 2020012629A
Authority
MX
Mexico
Prior art keywords
synthesis
peptide
same
solution phase
peptide synthesis
Prior art date
Application number
MX2020012629A
Other languages
English (en)
Inventor
Cole Seifert
Original Assignee
Sederma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sederma Sa filed Critical Sederma Sa
Publication of MX2020012629A publication Critical patent/MX2020012629A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención descrita se relaciona generalmente al campo de la síntesis de péptido. Se describe un método novedoso de síntesis de péptido en fase de solución que utiliza grupos protectores de purificación asistida por grupo novedosos para facilitar la química escalable, eficiente para fabricar péptidos sintéticamente. La invención descrita se dirige a las fallas en la técnica al reducir notablemente el desecho, incrementar la escalabilidad y proporcionar altas purezas del material crudo para evitar en gran medida la purificación de post-síntesis.
MX2020012629A 2018-05-31 2019-05-21 Metodo para sintesis de peptido en fase de solucion y estrategias protectoras de la misma. MX2020012629A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862678564P 2018-05-31 2018-05-31
PCT/US2019/033296 WO2019231760A1 (en) 2018-05-31 2019-05-21 Method for solution-phase peptide synthesis and protecting strategies therefore

Publications (1)

Publication Number Publication Date
MX2020012629A true MX2020012629A (es) 2021-01-29

Family

ID=68697631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012629A MX2020012629A (es) 2018-05-31 2019-05-21 Metodo para sintesis de peptido en fase de solucion y estrategias protectoras de la misma.

Country Status (8)

Country Link
EP (1) EP3802554B1 (es)
JP (2) JP7641895B2 (es)
KR (1) KR102826649B1 (es)
CN (1) CN112236436B (es)
CA (1) CA3098707A1 (es)
IL (1) IL278412B2 (es)
MX (1) MX2020012629A (es)
WO (1) WO2019231760A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7641895B2 (ja) * 2018-05-31 2025-03-07 セデルマ 液相ペプチド合成のための方法およびその保護戦略
US12024537B2 (en) * 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
US11827660B2 (en) 2019-02-01 2023-11-28 Sederma Synthesis strategy for gap protecting group
TW202302620A (zh) * 2021-03-19 2023-01-16 日商富士軟片股份有限公司 胺基酸或肽之製造方法、保護基形成用試藥及化合物
WO2022226536A1 (en) * 2021-04-23 2022-10-27 Sederma Compositions for chemical synthesis of peptides
JP7154513B1 (ja) 2021-07-02 2022-10-18 ペプチスター株式会社 液相ペプチド製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
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JPS58166747A (ja) * 1982-03-29 1983-10-01 Toshiba Corp 樹脂封止型半導体装置
AU665951B2 (en) * 1991-05-30 1996-01-25 Edward M. Halimi Method and apparatus for overcoming turbo lag
US5516891A (en) 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
IE921942A1 (en) * 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
WO1998041531A2 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
ITMI20050328A1 (it) * 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
IE20060841A1 (en) 2006-11-21 2008-05-28 Ipsen Mfg Ireland Ltd Boc and fmoc solid phase peptide synthesis
CA2673229A1 (en) * 2006-12-29 2008-07-10 F. Hoffmann-La Roche Ag Methods for the synthesis of cyclic peptides
CA2768299C (en) * 2009-07-13 2018-03-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
WO2012103444A2 (en) * 2011-01-28 2012-08-02 Purdue Research Foundation Immunogenic compositions and reagents for preparing
US20140128572A1 (en) * 2011-06-16 2014-05-08 Lonza Braine S.A. Process For Extraction Of Peptides And Its Application In Liquid Phase Peptide Synthesis
WO2014093723A2 (en) * 2012-12-12 2014-06-19 Nanjing University Group-assistant-purification (gap) synthesis of velcade, dimeric analogs, and amino compounds
KR102129650B1 (ko) * 2013-04-01 2020-07-02 가부시키가이샤 아데카 난연제 조성물, 난연제 조성물로 처리한 난연성 섬유 및 그 조성물에 의해 난연성분의 섬유에 대한 정착량을 증가시키는 방법
US10005816B2 (en) * 2014-12-15 2018-06-26 The Folger Coffee Company Peptides and their use in food and beverage
CN114874288A (zh) * 2015-07-09 2022-08-09 米梅奥亨制药公司 β-转角环状模拟肽盐的溶液相合成和结晶
KR102337328B1 (ko) * 2015-12-21 2021-12-10 텍사스 테크 유니버시티 시스템 용액상 gap 펩타이드 합성을 위한 시스템 및 방법
JP7641895B2 (ja) * 2018-05-31 2025-03-07 セデルマ 液相ペプチド合成のための方法およびその保護戦略

Also Published As

Publication number Publication date
IL278412A (es) 2020-12-31
IL278412B2 (en) 2026-02-01
EP3802554A4 (en) 2022-03-02
IL278412B1 (en) 2025-10-01
EP3802554A1 (en) 2021-04-14
JP2023052381A (ja) 2023-04-11
JP2021531326A (ja) 2021-11-18
CN112236436B (zh) 2024-03-29
EP3802554B1 (en) 2023-12-13
KR102826649B1 (ko) 2025-06-30
CN112236436A (zh) 2021-01-15
KR20210015816A (ko) 2021-02-10
WO2019231760A1 (en) 2019-12-05
CA3098707A1 (en) 2019-12-05
JP7641895B2 (ja) 2025-03-07

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