MX2020012503A - Métodos de tratamiento de neoplasias mieloproliferativas. - Google Patents
Métodos de tratamiento de neoplasias mieloproliferativas.Info
- Publication number
- MX2020012503A MX2020012503A MX2020012503A MX2020012503A MX2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- treating
- methods
- mpn
- formula
- Prior art date
Links
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 title abstract 4
- 208000032027 Essential Thrombocythemia Diseases 0.000 abstract 2
- 208000017733 acquired polycythemia vera Diseases 0.000 abstract 2
- 208000037244 polycythemia vera Diseases 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 229940126638 Akt inhibitor Drugs 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 229940122245 Janus kinase inhibitor Drugs 0.000 abstract 1
- 239000012270 PD-1 inhibitor Substances 0.000 abstract 1
- 239000012668 PD-1-inhibitor Substances 0.000 abstract 1
- 239000012271 PD-L1 inhibitor Substances 0.000 abstract 1
- 239000012272 PD-L2 inhibitor Substances 0.000 abstract 1
- 239000012828 PI3K inhibitor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 229940124302 mTOR inhibitor Drugs 0.000 abstract 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 abstract 1
- 206010028537 myelofibrosis Diseases 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 229940121655 pd-1 inhibitor Drugs 0.000 abstract 1
- 229940121656 pd-l1 inhibitor Drugs 0.000 abstract 1
- 229940121654 pd-l2 inhibitor Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 abstract 1
- 239000003197 protein kinase B inhibitor Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen métodos terapéuticos y composiciones farmacéuticas para tratar una neoplasia mieloproliferativa (MPN), que incluye policitemia vera (PV), trombocitemia esencial (ET) y mielofibrosis. En ciertas modalidades, la invención incluye métodos terapéuticos para tratar una MPN mediante el uso de una combinación de un compuesto de Fórmula (I) o Fórmula (II) con un agente terapéutico seleccionado del grupo que consiste en un inhibidor de JAK, un inhibidor de IDH, un inhibidor de PD-1, un inhibidor de PD-L1, un inhibidor de PD-L2, un interferón, un inhibidor de PI3K, un inhibidor de AKT, un inhibidor de mTOR, un análogo de nucleósido y sus combinaciones.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862676495P | 2018-05-25 | 2018-05-25 | |
| US201862781923P | 2018-12-19 | 2018-12-19 | |
| US201962814781P | 2019-03-06 | 2019-03-06 | |
| US201962835311P | 2019-04-17 | 2019-04-17 | |
| PCT/IB2019/095002 WO2019224803A2 (en) | 2018-05-25 | 2019-05-25 | Methods of treating myeloproliferative neoplasms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020012503A true MX2020012503A (es) | 2021-08-11 |
Family
ID=68615938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012503A MX2020012503A (es) | 2018-05-25 | 2019-05-25 | Métodos de tratamiento de neoplasias mieloproliferativas. |
| MX2025009369A MX2025009369A (es) | 2018-05-25 | 2020-11-20 | Inhibidores de mdm2 para usarse en el tratamiento de neoplasias mieloproliferativas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2025009369A MX2025009369A (es) | 2018-05-25 | 2020-11-20 | Inhibidores de mdm2 para usarse en el tratamiento de neoplasias mieloproliferativas |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12268681B2 (es) |
| EP (1) | EP3801476A4 (es) |
| JP (2) | JP2021525795A (es) |
| KR (1) | KR20210043499A (es) |
| CN (1) | CN112804994A (es) |
| AU (2) | AU2019273850B2 (es) |
| CA (1) | CA3100973A1 (es) |
| MX (2) | MX2020012503A (es) |
| WO (1) | WO2019224803A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022547311A (ja) * | 2019-09-16 | 2022-11-11 | ノバルティス アーゲー | 骨髄線維症の治療のためのｍｄｍ２阻害剤の使用 |
| EP4171512B1 (en) * | 2020-06-24 | 2026-01-28 | Novartis AG | Oral liquid formulations of ruxolitinib |
| CN114507234A (zh) * | 2020-10-13 | 2022-05-17 | 上海健康医学院 | 11c标记osi-027化合物及其制备方法及应用 |
| US20250092035A1 (en) * | 2022-01-25 | 2025-03-20 | The Wistar Institute Of Anatomy And Biology | Isocitrate dehydrogenase 1 inhibitors and methods of use thereof |
| WO2024031406A1 (en) * | 2022-08-10 | 2024-02-15 | Xiang Li | Idh mutations as biomarkers for zotiraciclib therapy |
| KR20250151363A (ko) * | 2022-12-09 | 2025-10-21 | 카토스 테라퓨틱스, 인크. | 골수증식성 신생물의 치료 방법 |
| WO2025179037A1 (en) * | 2024-02-20 | 2025-08-28 | Kartos Therapeutics | Systems and methods for processing clinical trial data |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101737753B1 (ko) * | 2007-03-12 | 2017-05-18 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| HUE029767T2 (en) * | 2008-03-11 | 2017-04-28 | Incyte Holdings Corp | JAK inhibitor azetidine and cyclobutane derivatives |
| DK2928477T3 (da) | 2012-12-07 | 2019-10-07 | Geron Corp | Anvendelse af telomeraseinhibitor imetelstat til behandling af myelofibrosis |
| CN105121407B (zh) | 2013-02-28 | 2017-07-18 | 美国安进公司 | 用于治疗癌症的苯甲酸衍生物mdm2抑制剂 |
| US20140327948A1 (en) | 2013-05-06 | 2014-11-06 | Pixtronix, Inc. | Display elements incorporating asymmetric apertures |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| TN2016000176A1 (en) * | 2013-11-11 | 2017-10-06 | Amgen Inc | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers. |
| EP3102238A1 (en) | 2014-01-20 | 2016-12-14 | Gilead Sciences, Inc. | Therapies for treating cancers |
| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| AU2016291578C1 (en) | 2015-07-10 | 2021-07-15 | Arvinas Operations, Inc. | MDM2-based modulators of proteolysis and associated methods of use |
-
2019
- 2019-05-25 KR KR1020207036963A patent/KR20210043499A/ko not_active Ceased
- 2019-05-25 CN CN201980049262.8A patent/CN112804994A/zh active Pending
- 2019-05-25 WO PCT/IB2019/095002 patent/WO2019224803A2/en not_active Ceased
- 2019-05-25 JP JP2021515308A patent/JP2021525795A/ja active Pending
- 2019-05-25 CA CA3100973A patent/CA3100973A1/en active Pending
- 2019-05-25 MX MX2020012503A patent/MX2020012503A/es unknown
- 2019-05-25 US US17/057,913 patent/US12268681B2/en active Active
- 2019-05-25 AU AU2019273850A patent/AU2019273850B2/en active Active
- 2019-05-25 EP EP19807406.4A patent/EP3801476A4/en active Pending
-
2020
- 2020-11-20 MX MX2025009369A patent/MX2025009369A/es unknown
-
2025
- 2025-01-30 JP JP2025013469A patent/JP2025072429A/ja active Pending
- 2025-02-06 AU AU2025200802A patent/AU2025200802A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12268681B2 (en) | 2025-04-08 |
| JP2021525795A (ja) | 2021-09-27 |
| JP2025072429A (ja) | 2025-05-09 |
| CN112804994A (zh) | 2021-05-14 |
| CA3100973A1 (en) | 2019-11-28 |
| WO2019224803A3 (en) | 2020-06-11 |
| AU2019273850B2 (en) | 2024-11-14 |
| WO2019224803A2 (en) | 2019-11-28 |
| US20220054472A1 (en) | 2022-02-24 |
| EP3801476A4 (en) | 2022-07-06 |
| AU2019273850A1 (en) | 2021-01-07 |
| KR20210043499A (ko) | 2021-04-21 |
| AU2025200802A1 (en) | 2025-03-06 |
| MX2025009369A (es) | 2025-09-02 |
| EP3801476A2 (en) | 2021-04-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2020012503A (es) | Métodos de tratamiento de neoplasias mieloproliferativas. | |
| CL2021003477A1 (es) | Compuestos 2,3-dihidroquinazolin como inhibidores nav1 .8 | |
| AR131056A2 (es) | Composiciones para tratar un trastorno hipofosfatémico | |
| PE20151499A1 (es) | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico | |
| ECSP20079887A (es) | Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores pd-l1 | |
| CL2019000941A1 (es) | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret. | |
| UY37435A (es) | Pirrolidinas sustituidas y métodos para usarlas | |
| MX2021016054A (es) | Analogos sinteticos de las ecteinascidinas y su uso como agentes antitumorales. | |
| CO2018003500A2 (es) | Anticuerpos anti-pd-1 y composiciones | |
| CR20170575A (es) | Nuevos derivados bicíclicos, un proceso para su preparación y composiciones farmacéuticas que los continen. | |
| MX2023000782A (es) | 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia. | |
| MX384948B (es) | Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos. | |
| NI201700129A (es) | Azabenzimidazoles y su uso como moduladores del receptor ampa. | |
| UY37952A (es) | Formulaciones de un inhibidor de la quinasa trk macrocíclica | |
| MX387596B (es) | Degradadores selectivos del receptor de estrógeno y sus usos. | |
| DOP2016000208A (es) | Benzimidazol-2-aminas como inhibidores de midh1 | |
| MX2020007485A (es) | Compuestos antiproliferativos y metodos de uso de los mismos. | |
| MX2016012446A (es) | Derivados de quinoxalina utiles como amortiguadaores de receptor del factor de crecimiento de fibroblastos (fgfr) cinasa. | |
| CL2015001864A1 (es) | Compuestos derivados de espiropirido[1,2-a]pirazina sustituidos, como inhibidores de la integrasa del vih; composicion farmaceutica que los comprende; y su uso para la profilaxis o el tratamiento de una infeccion por vih. | |
| NI201000004A (es) | Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas. | |
| CL2013003160A1 (es) | Compuestos derivados de 4h-cromen-4-ona moduladores de la proteina cinasa pi3k; compuestos intermediarios; composicion farmaceutica que los comprende; y utiles en el tratamiento del cancer, agentes antinflamatorios, inmunosupresores, esteroides, analgesicos, leucemia, entre otros. | |
| CL2018001171A1 (es) | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer | |
| CL2015001377A1 (es) | Inhbibidores de bmi-1 primidinas sustituidas inversas | |
| ECSP17026210A (es) | Compuestos de aminopurina sustituida, composiciones del mismo, y métodos de tratamiento con los mismos | |
| MX373652B (es) | Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa. |