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MX2020009566A - Compuestos como moduladores de la se?alizacion de tlr2. - Google Patents

Compuestos como moduladores de la se?alizacion de tlr2.

Info

Publication number
MX2020009566A
MX2020009566A MX2020009566A MX2020009566A MX2020009566A MX 2020009566 A MX2020009566 A MX 2020009566A MX 2020009566 A MX2020009566 A MX 2020009566A MX 2020009566 A MX2020009566 A MX 2020009566A MX 2020009566 A MX2020009566 A MX 2020009566A
Authority
MX
Mexico
Prior art keywords
compounds
modulators
tlr2 signaling
treatment
tlr2
Prior art date
Application number
MX2020009566A
Other languages
English (en)
Inventor
Wolfgang Wrasidlo
Srinivasa Reddy Natala
Original Assignee
Neuropore Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuropore Therapies Inc filed Critical Neuropore Therapies Inc
Publication of MX2020009566A publication Critical patent/MX2020009566A/es

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    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Steroid Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente descripción se refiere a compuestos, composiciones farmacéuticas que comprenden dichos compuestos, y al uso de dichos compuestos en métodos de tratamiento o en medicamentos para el tratamiento de enfermedades inflamatorias y determinados trastornos neurológicos que están relacionados con procesos inflamatorios de señalización, que incluyen, de modo no taxativo, proteínas mal plegadas.
MX2020009566A 2018-03-27 2019-03-27 Compuestos como moduladores de la se?alizacion de tlr2. MX2020009566A (es)

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EP4295846A3 (en) 2019-05-10 2024-02-28 Deciphera Pharmaceuticals, LLC Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
US11590134B2 (en) 2019-06-17 2023-02-28 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
MX2023003348A (es) * 2020-09-25 2023-03-29 Neuropore Therapies Inc Compuestos y composiciones como moduladores de señalización tlr.
CN119638556B (zh) * 2024-12-09 2025-09-26 华中科技大学 一种二苯乙烯衍生物及其制备方法和在制备治疗银屑病或溃疡性结肠炎的药物中的应用
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PL3774736T3 (pl) 2023-03-13
EA202092305A1 (ru) 2020-12-07
CA3093553A1 (en) 2019-10-03
US11345713B2 (en) 2022-05-31
IL277418B1 (en) 2025-11-01
SI3774736T1 (sl) 2023-03-31
HUE061248T2 (hu) 2023-06-28
IL277418A (en) 2020-11-30
WO2019191189A1 (en) 2019-10-03
PT3774736T (pt) 2023-02-13
ES2938278T3 (es) 2023-04-05
RS63915B1 (sr) 2023-02-28
EP3774736B1 (en) 2022-11-16
KR20200138323A (ko) 2020-12-09
CN112020494A (zh) 2020-12-01
SG11202008361YA (en) 2020-09-29
AU2019242734A1 (en) 2020-09-24
BR112020019708A2 (pt) 2021-02-09
US20210024539A1 (en) 2021-01-28
JP7402170B2 (ja) 2023-12-20
US20220396583A1 (en) 2022-12-15
EP3774736A1 (en) 2021-02-17
JP2021519316A (ja) 2021-08-10
HRP20230125T1 (hr) 2023-06-09
DK3774736T3 (da) 2023-01-30
FI3774736T3 (fi) 2023-02-28

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