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MX2020008224A - Anticuerpo biespecifico. - Google Patents

Anticuerpo biespecifico.

Info

Publication number
MX2020008224A
MX2020008224A MX2020008224A MX2020008224A MX2020008224A MX 2020008224 A MX2020008224 A MX 2020008224A MX 2020008224 A MX2020008224 A MX 2020008224A MX 2020008224 A MX2020008224 A MX 2020008224A MX 2020008224 A MX2020008224 A MX 2020008224A
Authority
MX
Mexico
Prior art keywords
autoimmune diseases
bispecific antibodies
suppression
inventors
confirmed
Prior art date
Application number
MX2020008224A
Other languages
English (en)
Inventor
Mark Throsby
Loo Pieter Fokko Van
Kruif Cornelis Adriaan De
Shiro Shibayama
Rinse Klooster
Takuya Shimbo
Tomoya Tezuka
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of MX2020008224A publication Critical patent/MX2020008224A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención aborda el problema de proporcionar un nuevo fármaco para la prevención de enfermedades autoinmunes, la supresión de la progresión de los síntomas de enfermedades autoinmunes, la supresión de la recurrencia de enfermedades autoinmunes o el tratamiento de enfermedades autoinmunes. Como resultado de una investigación diligente, los inventores de la presente invención se han centrado en los anticuerpos biespecíficos de PD-1/CD3 como sustancias que pueden resolver el problema mencionado anteriormente y han confirmado que tales anticuerpos biespecíficos hacen posible lograr productos farmacéuticos que reducen la aparición de los efectos adversos conocidos como una reacción relacionada con la perfusión y el síndrome de liberación de citocinas. Además, los inventores han confirmado que tales anticuerpos biespecíficos permiten la interacción entre PD-1 y su ligando PD-L1 y han descubierto que tal característica contribuye a una actividad mejorada y sostenida.
MX2020008224A 2018-02-09 2019-02-08 Anticuerpo biespecifico. MX2020008224A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018021498 2018-02-09
JP2018153149 2018-08-16
PCT/JP2019/004551 WO2019156199A1 (ja) 2018-02-09 2019-02-08 二重特異性抗体

Publications (1)

Publication Number Publication Date
MX2020008224A true MX2020008224A (es) 2020-09-25

Family

ID=67549433

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008224A MX2020008224A (es) 2018-02-09 2019-02-08 Anticuerpo biespecifico.

Country Status (15)

Country Link
US (3) US11091550B2 (es)
EP (1) EP3763743A4 (es)
JP (2) JP6844719B2 (es)
KR (1) KR20200119244A (es)
CN (1) CN111670203B (es)
AU (1) AU2019217006B2 (es)
BR (1) BR112020016220A2 (es)
CA (1) CA3089722A1 (es)
IL (1) IL276250A (es)
MX (1) MX2020008224A (es)
PH (1) PH12020551124A1 (es)
SG (1) SG11202007531YA (es)
TW (3) TWI804572B (es)
WO (1) WO2019156199A1 (es)
ZA (1) ZA202004908B (es)

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TWI804572B (zh) * 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
TWI862565B (zh) * 2019-04-04 2024-11-21 日商小野藥品工業股份有限公司 雙特異性抗體
BR112021022682A2 (pt) 2019-05-14 2022-02-22 Provention Bio Inc Métodos e composições para prevenir diabetes do tipo 1
TWI809286B (zh) * 2019-07-05 2023-07-21 日商小野藥品工業股份有限公司 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療
CN114174343A (zh) * 2019-07-30 2022-03-11 小野药品工业株式会社 双特异性抗体
EP4011918A4 (en) * 2019-08-08 2023-08-23 ONO Pharmaceutical Co., Ltd. DUAL SPECIFIC PROTEIN
JP7686180B2 (ja) * 2020-04-17 2025-06-02 小野薬品工業株式会社 タンパク質製剤原薬の着色除去方法
CA3182445A1 (en) 2020-06-11 2021-12-16 Francisco Leon Methods and compositions for preventing type 1 diabetes
JPWO2022239820A1 (es) 2021-05-13 2022-11-17
CN116041511B (zh) * 2023-02-21 2025-10-10 郑州伊美诺生物技术有限公司 Acth重组兔单克隆抗体、制备方法及其应用
TW202502380A (zh) 2023-03-16 2025-01-16 日商小野藥品工業股份有限公司 抗體製劑
JP7548475B1 (ja) * 2023-03-16 2024-09-10 小野薬品工業株式会社 抗体製剤

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Also Published As

Publication number Publication date
AU2019217006B2 (en) 2025-01-09
CA3089722A1 (en) 2019-08-15
CN111670203B (zh) 2023-11-14
CN111670203A (zh) 2020-09-15
KR20200119244A (ko) 2020-10-19
JP2021063142A (ja) 2021-04-22
TW202438530A (zh) 2024-10-01
ZA202004908B (en) 2022-06-29
AU2019217006A1 (en) 2020-08-27
RU2020125508A (ru) 2022-03-09
US12091461B2 (en) 2024-09-17
US20210332134A1 (en) 2021-10-28
BR112020016220A2 (pt) 2020-12-15
TWI804572B (zh) 2023-06-11
SG11202007531YA (en) 2020-09-29
TWI890481B (zh) 2025-07-11
JPWO2019156199A1 (ja) 2021-01-28
US20210214441A1 (en) 2021-07-15
NZ761547A (en) 2023-11-24
US11091550B2 (en) 2021-08-17
JP7363828B2 (ja) 2023-10-18
WO2019156199A1 (ja) 2019-08-15
TW201942132A (zh) 2019-11-01
TW202340257A (zh) 2023-10-16
PH12020551124A1 (en) 2021-05-31
EP3763743A1 (en) 2021-01-13
EP3763743A4 (en) 2022-05-11
JP6844719B2 (ja) 2021-03-17
IL276250A (en) 2020-09-30
US20240287187A1 (en) 2024-08-29
TWI849895B (zh) 2024-07-21

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