[go: up one dir, main page]

MX2020008184A - CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD70. - Google Patents

CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD70.

Info

Publication number
MX2020008184A
MX2020008184A MX2020008184A MX2020008184A MX2020008184A MX 2020008184 A MX2020008184 A MX 2020008184A MX 2020008184 A MX2020008184 A MX 2020008184A MX 2020008184 A MX2020008184 A MX 2020008184A MX 2020008184 A MX2020008184 A MX 2020008184A
Authority
MX
Mexico
Prior art keywords
cars
chimeric antigen
antigen receptors
immune cells
engineered immune
Prior art date
Application number
MX2020008184A
Other languages
Spanish (es)
Inventor
Blarcom Thomas John Van
Barbra Johnson Sasu
Tao Sai
Srinivasan Surabhi Srivatsa
Niranjana Aditi Nagarajan
Siler Panowski
Yoon Park
Mathilde Brunnhilde DUSSEAUX
Roman Ariel Galetto
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2020008184A publication Critical patent/MX2020008184A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4232—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/56—Kidney
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La descripción proporciona CAR (CAR) que se unen específicamente a CD70. La descripción se refiere, además, a células inmunitarias modificadas por ingeniería genética que comprenden dichos CAR, ácidos nucleicos que codifican CAR, y métodos para fabricar dichos CAR, células inmunitarias modificadas por ingeniería genética, y 5 ácidos nucleicos. La descripción se refiere, además, a métodos terapéuticos para el uso de estos CAR y células inmunitarias modificadas por ingeniería genética que comprenden estos CAR para el tratamiento de una afección asociada con células malignas que expresan CD70 (por ejemplo, cáncer).The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising said CARs, CAR-encoding nucleic acids, and methods for making said CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for the use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with CD70-expressing malignant cells (eg, cancer).

MX2020008184A 2018-02-01 2019-01-31 CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD70. MX2020008184A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862625009P 2018-02-01 2018-02-01
US201862625019P 2018-02-01 2018-02-01
US201862641873P 2018-03-12 2018-03-12
US201862641869P 2018-03-12 2018-03-12
US201862775246P 2018-12-04 2018-12-04
PCT/US2019/016189 WO2019152742A1 (en) 2018-02-01 2019-01-31 Chimeric antigen receptors targeting cd70

Publications (1)

Publication Number Publication Date
MX2020008184A true MX2020008184A (en) 2020-09-22

Family

ID=65686921

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008184A MX2020008184A (en) 2018-02-01 2019-01-31 CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD70.

Country Status (15)

Country Link
US (3) US11396551B2 (en)
EP (1) EP3746483A1 (en)
JP (3) JP7404247B2 (en)
KR (2) KR102780406B1 (en)
CN (1) CN112020518A (en)
AU (1) AU2019216420B2 (en)
BR (1) BR112020015662A2 (en)
CA (1) CA3089318A1 (en)
IL (2) IL322656A (en)
MX (1) MX2020008184A (en)
PE (2) PE20252242A1 (en)
PH (1) PH12020551160A1 (en)
SG (1) SG11202006883QA (en)
TW (1) TW201936633A (en)
WO (1) WO2019152742A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202090931A3 (en) 2015-05-18 2020-10-30 Тср2 Терапьютикс Инк. COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING WITH HYBRID PROTEINS
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
PE20252242A1 (en) * 2018-02-01 2025-09-15 Pfizer CHIMERIC ANTIGEN RECEPTORS TARGETED AT CD70
WO2019152705A1 (en) 2018-02-01 2019-08-08 Pfizer Inc. Antibodies specific for cd70 and their uses
MX2020012028A (en) 2018-05-11 2021-03-29 Crispr Therapeutics Ag Methods and compositions for treating cancer.
CN109053882B (en) * 2018-08-28 2019-08-23 东莞市朋志生物科技有限公司 A binding protein of NS1 protein and application
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
MX2022002763A (en) * 2019-09-06 2022-04-06 Crispr Therapeutics Ag T LYMPHOCYTES MODIFIED BY GENETIC ENGINEERING THAT HAVE IMPROVED PERSISTENCE IN CULTURE.
EP4031150A4 (en) * 2019-09-16 2023-11-01 The General Hospital Corporation Cd70 targeted chimeric antigen receptor (car) t cells and uses thereof
CN114929267A (en) * 2019-11-13 2022-08-19 克里斯珀医疗股份公司 Renal Cell Carcinoma (RCC) therapy using genetically engineered T cells targeting CD70
TW202132560A (en) * 2019-11-13 2021-09-01 瑞士商Ｃｒｉｓｐｒ治療公司 Methods of manufacturing car-t cells
AU2020385062A1 (en) * 2019-11-13 2022-05-19 Crispr Therapeutics Ag CD70+ solid tumor therapy using genetically engineered T cells targeting CD70
JP2023501590A (en) * 2019-11-13 2023-01-18 クリスパー セラピューティクス アクチェンゲゼルシャフト Therapy for hematopoietic cell malignancies using genetically engineered T cells that target CD70
CN115397853A (en) 2019-12-17 2022-11-25 辉瑞大药厂 Antibody with specificity to CD47 and PD-L1 and application thereof
KR20220125805A (en) * 2020-01-08 2022-09-14 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 How to engineer natural killer cells to target CD70-positive tumors
US20240252641A1 (en) * 2020-05-05 2024-08-01 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using cd70 specific fusion proteins
IL298510A (en) * 2020-06-12 2023-01-01 Nkarta Inc Genetically modified natural killer cells for CD70-tuned cancer immunotherapy
CA3195114A1 (en) * 2020-10-09 2022-04-14 Martin Klatt Compositions targeting ndc80/mhc complexes and uses thereof
IL302728A (en) 2020-11-13 2023-07-01 Catamaran Bio Inc Genetically modified natural killer cells and methods of using them
WO2022115611A1 (en) 2020-11-25 2022-06-02 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
MX2023007384A (en) 2020-12-21 2023-07-05 Allogene Therapeutics Inc CAR WITH DOOR CD45 PROTEASE ACTIVATED.
MX2023008809A (en) 2021-01-29 2023-08-04 Allogene Therapeutics Inc KNOCKDOWN OR KNOCKOUT OF ONE OR MORE OF TAP2, NLRC5, ß2m, TRAC, RFX5, RFXAP AND RFXANK TO MITIGATE T CELL RECOGNITION OF ALLOGENEIC CELL PRODUCTS.
AR125851A1 (en) * 2021-05-12 2023-08-16 Crispr Therapeutics Ag GENETICALLY MODIFIED IMMUNE CELLS THAT FOCUS ON CD70 FOR USE IN THE TREATMENT OF HEMATOPOIETIC MALIGNANT NEOPLASMS
AR125852A1 (en) * 2021-05-12 2023-08-16 Crispr Therapeutics Ag GENETICALLY MODIFIED IMMUNE CELLS THAT FOCUS ON CD70 FOR USE IN THE TREATMENT OF SOLID TUMORS
BR112023026249A2 (en) 2021-06-15 2024-03-05 Allogene Therapeutics Inc SELECTIVE TARGETING OF HOST ALLOREACTIVE CD70+ CELLS TO PROLONG THE PERSISTENCE OF ALLOGENIC CAR T CELLS
AU2022303155A1 (en) * 2021-06-30 2024-01-25 Board Of Regents, The University Of Texas System Polypeptides targeting cd70-positive cancers
WO2023072307A1 (en) * 2021-10-25 2023-05-04 重庆精准生物技术有限公司 Antigen binding fragment targeting cd70, single-chain antibody and chimeric antigen receptor, and use thereof
CN119654406A (en) 2022-07-29 2025-03-18 艾洛基治疗公司 Engineered cells with reduced gene expression to mitigate immune cell recognition
WO2024129967A1 (en) * 2022-12-14 2024-06-20 Allogene Therapeutics Inc. Cd70 anti-idiotype antibodies
TWI871168B (en) * 2023-01-16 2025-01-21 大陸商上海華奧泰生物藥業股份有限公司 Antibodies targeting CD70 or antigen-binding fragments binding to CD70 and preparation methods and applications thereof
US20240392023A1 (en) * 2023-05-18 2024-11-28 Abclon Inc. Anti-cd30 antibody and chimeric antigen receptor comprising thereof
WO2025096560A1 (en) 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5047335A (en) 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2752788B2 (en) 1989-01-23 1998-05-18 カイロン コーポレイション Recombinant therapy for infection and hyperproliferative disorders
US6673776B1 (en) 1989-03-21 2004-01-06 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
DK0737750T3 (en) 1989-03-21 2003-09-01 Vical Inc Expression of exogenous polynucleotide sequences in vertebrates
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
EP0845537A1 (en) 1989-08-18 1998-06-03 Chiron Corporation Recombinant retroviruses delivering vector constructs to target cells
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
ZA911974B (en) 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DK0814159T3 (en) 1990-08-29 2005-10-24 Genpharm Int Transgenic, non-human animals capable of forming heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2113940T3 (en) 1990-12-03 1998-05-16 Genentech Inc ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES.
US5278299A (en) 1991-03-18 1994-01-11 Scripps Clinic And Research Foundation Method and composition for synthesizing sialylated glycosyl compounds
EP0586505A1 (en) 1991-05-14 1994-03-16 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
DE69233482T2 (en) 1991-05-17 2006-01-12 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
DE122004000008I1 (en) 1991-06-14 2005-06-09 Genentech Inc Humanized heregulin antibody.
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
CA2115742A1 (en) 1991-08-20 1993-03-04 Ronald G. Crystal Adenovirus mediated transfer of genes to the gastrointestinal tract
CA2078539C (en) 1991-09-18 2005-08-02 Kenya Shitara Process for producing humanized chimera antibody
ATE181571T1 (en) 1991-09-23 1999-07-15 Medical Res Council METHODS FOR PRODUCING HUMANIZED ANTIBODIES
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
AU3144193A (en) 1991-11-21 1993-06-15 Board Of Trustees Of The Leland Stanford Junior University Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
FR2688514A1 (en) 1992-03-16 1993-09-17 Centre Nat Rech Scient Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JPH07507689A (en) 1992-06-08 1995-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Specific tissue targeting methods and compositions
CA2137361A1 (en) 1992-06-10 1993-12-23 W. French Anderson Vector particles resistant to inactivation by human serum
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
WO1994004690A1 (en) 1992-08-17 1994-03-03 Genentech, Inc. Bispecific immunoadhesins
US6210671B1 (en) 1992-12-01 2001-04-03 Protein Design Labs, Inc. Humanized antibodies reactive with L-selectin
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
JP3545403B2 (en) 1993-04-22 2004-07-21 スカイファルマ インコーポレイテッド Cyclodextrin liposomes encapsulating pharmaceutical compounds and methods of use
US6180377B1 (en) 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
JP3532566B2 (en) 1993-06-24 2004-05-31 エル． グラハム，フランク Adenovirus vectors for gene therapy
CA2158937C (en) 1993-09-15 2006-01-03 Thomas W. Dubensky, Jr. Recombinant alphavirus vectors
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
PL186073B1 (en) 1993-10-25 2003-10-31 Canji Recombinated adenovirus vector and method of using it
CA2176712C (en) 1993-11-16 2000-05-23 Mantripragada Sankaram Synthetic membrane vesicles with controlled release of encapsulated biologically active substances
US6436908B1 (en) 1995-05-30 2002-08-20 Duke University Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
EP0772689B1 (en) 1994-05-09 2007-12-19 Oxford Biomedica (UK) Limited Retroviral vectors having a reduced recombination rate
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
WO1996017072A2 (en) 1994-11-30 1996-06-06 Chiron Viagene, Inc. Recombinant alphavirus vectors
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
WO1997042338A1 (en) 1996-05-06 1997-11-13 Chiron Corporation Crossless retroviral vectors
AU9692198A (en) 1997-10-10 1999-05-03 Kevin J. Donahue Gene delivery compositions and methods
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6849425B1 (en) 1999-10-14 2005-02-01 Ixsys, Inc. Methods of optimizing antibody variable region binding affinity
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
AU4328801A (en) 2000-02-24 2001-09-03 Xcyte Therapies Inc Simultaneous stimulation and concentration of cells
KR101410692B1 (en) 2002-12-24 2014-06-24 리나트 뉴로사이언스 코프. Anti-ngf antibodies and methods using same
US7491390B2 (en) 2004-10-15 2009-02-17 Seattle Genetics, Inc. Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
EP1871417B1 (en) 2005-04-15 2013-09-11 Precision Biologics, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
US8067546B2 (en) 2005-04-19 2011-11-29 Seattle Genetics, Inc. Humanized anti-CD70 binding agents and uses thereof
CA2623236A1 (en) 2005-09-26 2007-04-05 Medarex, Inc. Human monoclonal antibodies to cd70
US8409577B2 (en) 2006-06-12 2013-04-02 Emergent Product Development Seattle, Llc Single chain multivalent binding proteins with effector function
EP2335744A4 (en) 2008-08-26 2011-07-27 Univ Hokkaido Nat Univ Corp BONE FILL TYPE AGENT FOR INDUCING CARTILAGE REGENERATION
JP6022444B2 (en) 2010-05-14 2016-11-09 ライナット ニューロサイエンス コーポレイション Heterodimeric protein and method for producing and purifying it
WO2012058460A2 (en) 2010-10-27 2012-05-03 Baylor College Of Medicine Chimeric cd27 receptors for redirecting t cells to cd70-positive malignancies
JP2013544082A (en) 2010-10-27 2013-12-12 セレクティス Method for increasing the efficiency of double-strand break-induced mutagenesis
EP2635310A2 (en) 2010-11-05 2013-09-11 Rinat Neuroscience Corp. Engineered polypeptide conjugates and methods for making thereof using transglutaminase
JP5982409B2 (en) 2011-03-16 2016-09-07 アルゲン−エックス エヌ．ブイ． Antibodies against CD70
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
JP6352920B2 (en) 2012-09-04 2018-07-04 セレクティス Multi-chain chimeric antigen receptor and uses thereof
EP2997133B1 (en) 2013-05-13 2023-08-23 Cellectis Methods for engineering highly active t cell for immunotherapy
PL3546572T3 (en) 2013-05-13 2024-07-22 Cellectis Cd19 specific chimeric antigen receptor and uses thereof
DK3004337T3 (en) 2013-05-29 2017-11-13 Cellectis Method for constructing T cells for immunotherapy using RNA-guided Cas nuclease system
WO2015015448A2 (en) 2013-07-31 2015-02-05 Rinat Neuroscience Corp. Engineered polypeptide conjugates
AU2015216875B2 (en) * 2014-02-14 2021-02-25 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
US10174095B2 (en) 2014-07-21 2019-01-08 Novartis Ag Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor
CN107207616B (en) * 2014-12-08 2021-11-19 美国卫生和人力服务部 anti-CD70 chimeric antigen receptor
DK3250606T3 (en) * 2015-01-26 2021-01-04 Cellectis ANTI-CLL1-specific single-chain chimeric antigen receptors (SCCARS) for cancer immunotherapy
DE102015101304B3 (en) 2015-01-29 2016-03-17 Fujitsu Technology Solutions Intellectual Property Gmbh Rack server for a server rack
PL3283106T3 (en) 2015-04-13 2022-05-02 Pfizer Inc. Therapeutic antibodies and their uses
ES2807591T3 (en) 2015-04-13 2021-02-23 Pfizer Chimeric antigen receptors targeting B-cell maturation antigen
EA039859B1 (en) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
TWI717375B (en) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Antibody constructs for cd70 and cd3
ES2904593T3 (en) 2016-01-21 2022-04-05 Pfizer Monospecific and bispecific antibodies to epidermal growth factor receptor variant III and CD3 and their uses
PT3583129T (en) * 2017-02-14 2021-12-14 Kite Pharma Inc CD70 BINDING MOLECULES AND THEIR METHODS OF USE
PE20252242A1 (en) 2018-02-01 2025-09-15 Pfizer CHIMERIC ANTIGEN RECEPTORS TARGETED AT CD70
WO2019152705A1 (en) 2018-02-01 2019-08-08 Pfizer Inc. Antibodies specific for cd70 and their uses

Also Published As

Publication number Publication date
CA3089318A1 (en) 2019-08-08
KR20200128018A (en) 2020-11-11
WO2019152742A1 (en) 2019-08-08
US20190233528A1 (en) 2019-08-01
AU2019216420B2 (en) 2025-12-11
IL276396B2 (en) 2026-01-01
JP2024016034A (en) 2024-02-06
KR102780406B1 (en) 2025-03-17
CN112020518A (en) 2020-12-01
JP7404247B2 (en) 2023-12-25
TW201936633A (en) 2019-09-16
PE20211299A1 (en) 2021-07-20
IL276396B1 (en) 2025-09-01
EP3746483A1 (en) 2020-12-09
RU2020128741A (en) 2022-03-01
US12152081B2 (en) 2024-11-26
AU2019216420A1 (en) 2020-08-20
KR20250040087A (en) 2025-03-21
IL276396A (en) 2020-09-30
JP2026000897A (en) 2026-01-06
PE20252242A1 (en) 2025-09-15
SG11202006883QA (en) 2020-08-28
JP7770369B2 (en) 2025-11-14
PH12020551160A1 (en) 2021-05-31
US11396551B2 (en) 2022-07-26
BR112020015662A2 (en) 2020-12-08
US20230041456A1 (en) 2023-02-09
IL322656A (en) 2025-10-01
US20250145725A1 (en) 2025-05-08
JP2021511807A (en) 2021-05-13

Similar Documents

Publication Publication Date Title
MX2020008184A (en) CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD70.
CO2019013654A2 (en) Chimeric antigen receptors targeting flt3
CO2017010502A2 (en) Chimeric antigen receptors targeting the b-cell maturation antigen
MX2024009690A (en) ANTI-CD137 ANTIBODIES AND METHODS OF USE THEREOF.
MX2019006340A (en) CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODIES (CTLA-4) AND THE METHODS OF USE
BR112019011450A2 (en) modified natural killer cells and their use
MX2020009394A (en) ANTI-CD73 ANTIBODIES AND METHODS OF USE THEREOF.
MX2022003718A (en) ANTIBODIES THAT BIND TO CD39 AND THEIR USES.
MX2024010239A (en) CHIMERIC ANTIGEN RECEPTORS TARGETED TO BCMA AND METHODS OF USING THEM.
CL2024002250A1 (en) Use of anti-vd1 antibody to treat cancer, an infectious disease or an inflammatory disease.
CO2020000214A2 (en) Agonist antibodies that bind to human cd137 and their uses
CO2018010458A2 (en) Anti-tim-3 antibodies and compositions
CL2017002244A1 (en) Specific bispecific antibodies for fap and dr5, specific antibodies for dr5 and methods of use. (divisional application 2829-2015).
ES2944597T3 (en) Enhanced Efficacy Immune Effector Cell Therapies
PE20171764A1 (en) ANTI-CD3 ANTIBODIES, ANTI-CD123 ANTIBODIES, AND BISPECIFIC ANTIBODIES THAT SPECIFICALLY BIND CD3 AND / OR CD123
WO2018170338A3 (en) High affinity mage-a1-specific tcrs and uses thereof
MX2020009861A (en) Antibodies against mica and/or micb and uses thereof.
AR110676A1 (en) TREATMENT OF CANCER USING CHEMERIC ANTIGENS RECEPTORS
SV2016005266A (en) ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA
CO2017005650A2 (en) Anti-interleukin-33 antibodies
AR105433A1 (en) METHODS TO IMPROVE THE EFFECTIVENESS AND EXPANSION OF IMMUNE CELLS
AR102879A1 (en) METHODS FOR THE TREATMENT OF BRAIN TUMORS
CO6761352A2 (en) Anti-ccl20 neutralizing antibodies
MX2020007281A (en) COMPOSITIONS AND METHODS TARGETING CANCERS EXPRESSING CD99.
CO2022001977A2 (en) Anti-cd96 antibodies and their methods of use