MX2020006150A - Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas. - Google Patents
Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas.Info
- Publication number
- MX2020006150A MX2020006150A MX2020006150A MX2020006150A MX2020006150A MX 2020006150 A MX2020006150 A MX 2020006150A MX 2020006150 A MX2020006150 A MX 2020006150A MX 2020006150 A MX2020006150 A MX 2020006150A MX 2020006150 A MX2020006150 A MX 2020006150A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- circular polyribonucleotides
- polyribonucleotides
- circular
- preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere, en general, a composiciones farmacéuticas y a preparaciones de polirribonucleótidos circulares y a usos de las mismas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762599547P | 2017-12-15 | 2017-12-15 | |
| US201862676688P | 2018-05-25 | 2018-05-25 | |
| PCT/US2018/065836 WO2019118919A1 (en) | 2017-12-15 | 2018-12-14 | Compositions comprising circular polyribonucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006150A true MX2020006150A (es) | 2020-11-11 |
Family
ID=66820668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006150A MX2020006150A (es) | 2017-12-15 | 2018-12-14 | Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas. |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US12357653B2 (es) |
| EP (1) | EP3724208A4 (es) |
| JP (3) | JP2021508490A (es) |
| KR (1) | KR20200127152A (es) |
| CN (3) | CN120737150A (es) |
| AU (2) | AU2018385757B2 (es) |
| BR (1) | BR112020011670A2 (es) |
| CA (1) | CA3084824A1 (es) |
| IL (2) | IL316195A (es) |
| MA (1) | MA51155A (es) |
| MX (1) | MX2020006150A (es) |
| SG (1) | SG11202005060YA (es) |
| WO (1) | WO2019118919A1 (es) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL316195A (en) | 2017-12-15 | 2024-12-01 | Flagship Pioneering Innovations Vi Llc | Preparations containing circular polyribonucleotides and uses thereof |
| AU2019280583B2 (en) | 2018-06-06 | 2022-12-15 | Massachusetts Institute Of Technology | Circular RNA for translation in eukaryotic cells |
| WO2020181013A1 (en) * | 2019-03-04 | 2020-09-10 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides and pharmaceutical compositions thereof |
| CN115806976A (zh) * | 2019-03-20 | 2023-03-17 | 中国科学院上海营养与健康研究所 | 利用环形rna进行蛋白翻译及其应用 |
| CN113661242A (zh) | 2019-03-25 | 2021-11-16 | 旗舰创业创新第六有限责任公司 | 包含经修饰的环状多核糖核苷酸的组合物及其用途 |
| US20220162618A1 (en) * | 2019-03-25 | 2022-05-26 | Ohio State Innovation Foundation | Engineered mrna sequences and uses thereof |
| JP7686574B2 (ja) | 2019-05-22 | 2025-06-02 | マサチューセッツ インスティテュート オブ テクノロジー | 環状ｒｎａ組成物及び方法 |
| JP2022537154A (ja) * | 2019-06-14 | 2022-08-24 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 細胞治療のための環状ｒｎａ |
| US20220305128A1 (en) | 2019-06-19 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
| JP2022536951A (ja) | 2019-06-19 | 2022-08-22 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 環状ポリリボヌクレオチドを投与する方法 |
| CN112662659B (zh) * | 2019-10-15 | 2022-08-19 | 武汉核圣生物技术有限公司 | 一种普适性的mRNA体外环化方法 |
| WO2021081261A1 (en) * | 2019-10-22 | 2021-04-29 | The Regents Of The University Of California | Modulation of engineered immune cell receptor translation using noncoding sequence elements |
| EP4069830A4 (en) * | 2019-12-02 | 2024-10-02 | Regents of the University of California | Engineering circular guide rnas |
| CA3160739A1 (en) | 2019-12-04 | 2021-06-10 | Brian Goodman | Circular rna compositions and methods |
| CN115361954A (zh) * | 2020-01-29 | 2022-11-18 | 旗舰创业创新第六有限责任公司 | 用于翻译的组合物及其使用方法 |
| WO2021155171A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Delivery of compositions comprising circular polyribonucleotides |
| MX2022011677A (es) * | 2020-03-20 | 2023-01-11 | Orna Therapeutics Inc | Composiciones y métodos de arn circular. |
| AU2021276410A1 (en) * | 2020-05-19 | 2023-01-19 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
| US20230203192A1 (en) * | 2020-05-20 | 2023-06-29 | Flagship Pioneering, Inc. | Compositions and methods for producing human polyclonal antibodies |
| IL298363A (en) * | 2020-05-20 | 2023-01-01 | Flagship Pioneering Innovations Vi Llc | Immunogenic compositions and uses thereof |
| CA3179420A1 (en) | 2020-05-20 | 2021-11-25 | Avak Kahvejian | Coronavirus antigen compositions and their uses |
| CN111733243A (zh) * | 2020-06-29 | 2020-10-02 | 中山大学孙逸仙纪念医院 | 一种提高CircRNA检测准确率的方法 |
| CA3174356A1 (en) * | 2020-07-01 | 2022-01-06 | Santosh NARAYAN | Compositions and methods for cellular reprogramming using circular rna |
| EP4196139A2 (en) | 2020-08-12 | 2023-06-21 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| JP2023542492A (ja) * | 2020-09-03 | 2023-10-10 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 免疫原性組成物及びその使用 |
| IL303892A (en) | 2020-12-23 | 2023-08-01 | Flagship Pioneering Innovations V Inc | In vitro assembly of RNA-encapsulating enalavirus capsids |
| CN112562788B (zh) * | 2020-12-28 | 2022-06-28 | 上海交通大学 | 一种环状rna-rna结合蛋白关系预测模型构建方法 |
| JP7531237B2 (ja) | 2021-03-10 | 2024-08-09 | アールズィーノミクス・インコーポレイテッド | 自己環状化ｒｎａ構造体 |
| US20240181079A1 (en) | 2021-03-26 | 2024-06-06 | Flagship Pioneering Innovations Vii, Llc | Production of circular polyribonucleotides in a eukaryotic system |
| US20240263206A1 (en) | 2021-03-26 | 2024-08-08 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for producing circular polyribonucleotides |
| EP4314289A1 (en) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a prokaryotic system |
| US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| WO2022245942A1 (en) | 2021-05-18 | 2022-11-24 | Flagship Pioneering Innovations Vi, Llc | Methods of enriching for circular polyribonucleotides |
| CN117425735A (zh) | 2021-05-18 | 2024-01-19 | 旗舰创业创新第六有限责任公司 | 富集环状多核糖核苷酸的方法 |
| WO2023288287A2 (en) | 2021-07-15 | 2023-01-19 | Turn Biotechnologies, Inc. | Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment |
| US20230046606A1 (en) | 2021-07-15 | 2023-02-16 | Turn Biotechnologies, Inc. | Synthetic, persistent rna constructs with on/off mechanism for controlled expression and methods of use |
| AU2022318881A1 (en) | 2021-07-27 | 2024-02-08 | Flagship Pioneering Innovations Vi, Llc | Devices, systems and methods for processing |
| WO2023044343A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| EP4402123A1 (en) | 2021-09-14 | 2024-07-24 | Renagade Therapeutics Management Inc. | Cyclic lipids and methods of use thereof |
| WO2023044006A1 (en) | 2021-09-17 | 2023-03-23 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
| KR20240126857A (ko) | 2021-10-18 | 2024-08-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법 |
| EP4422698A1 (en) * | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| CA3235418A1 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| KR20240117569A (ko) | 2021-11-24 | 2024-08-01 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 코로나바이러스 면역원 조성물 및 그의 용도 |
| AU2022397300A1 (en) | 2021-11-24 | 2024-06-27 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and their uses |
| JP2024541466A (ja) | 2021-11-24 | 2024-11-08 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 水痘帯状疱疹ウイルス免疫原組成物及びその使用 |
| KR102488280B1 (ko) * | 2021-11-25 | 2023-01-16 | 주식회사 뉴클릭스바이오 | 신규한 부목 dna 및 이의 용도 |
| US20240401024A1 (en) | 2021-12-17 | 2024-12-05 | Flagship Pioneering Innovations Vi, Llc | Methods for enrichment of circular rna under denaturing conditions |
| MX2024007869A (es) | 2021-12-22 | 2024-08-20 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos para purificar polirribonucleotidos. |
| EP4452928A1 (en) | 2021-12-23 | 2024-10-30 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| CN118922211A (zh) | 2021-12-23 | 2024-11-08 | 旗舰创业创新六公司 | 编码抗融合多肽的环状多核糖核苷酸 |
| US20250108134A1 (en) * | 2022-01-28 | 2025-04-03 | Beijing Changping Laboratory | Circular rna vaccines and methods of use thereof |
| AU2023251104A1 (en) | 2022-04-07 | 2024-10-17 | Renagade Therapeutics Management Inc. | Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| TW202413424A (zh) | 2022-08-01 | 2024-04-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 免疫調節蛋白及相關方法 |
| JP2025530174A (ja) | 2022-09-06 | 2025-09-11 | アルジノミクス インコーポレイティド | 自己環状化ｒｎａ構造体 |
| JP2025530198A (ja) | 2022-09-06 | 2025-09-11 | アルジノミクス インコーポレイティド | 自己環状化ｒｎａ構造体 |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| CN120513299A (zh) | 2022-10-31 | 2025-08-19 | 旗舰创业创新第六有限责任公司 | 用于纯化多核糖核苷酸的组合物和方法 |
| TW202430636A (zh) * | 2022-11-08 | 2024-08-01 | 財團法人國家衛生研究院 | 環狀ｒｎａ及其製備方法和應用 |
| EP4615465A1 (en) | 2022-11-08 | 2025-09-17 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing circular polyribonucleotides |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於將治療劑遞送至骨之組成物和方法 |
| KR102584714B1 (ko) | 2022-12-28 | 2023-10-10 | 라이보텍(주) | 덤벨 구조를 이용한 원형 rna 제조 방법 |
| WO2024151673A2 (en) | 2023-01-09 | 2024-07-18 | President And Fellows Of Harvard College | Recombinant nucleic acid molecules and their use in wound healing |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2024151685A1 (en) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Recombinant nucleic acid molecules and their use in wound healing |
| TW202438673A (zh) | 2023-01-09 | 2024-10-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 疫苗及相關方法 |
| KR102581491B1 (ko) * | 2023-01-20 | 2023-09-25 | 한국과학기술원 | mRNA의 세포내 안정성과 생합성을 향상시키는 래리엇 캡 구조의 RNA, 및 이의 용도 |
| WO2024159111A1 (en) * | 2023-01-27 | 2024-08-02 | The Methodist Hospital | Methods of making and isolating circular rnas and circular rna compositions |
| WO2024159172A1 (en) | 2023-01-27 | 2024-08-02 | Senda Biosciences, Inc. | A modified lipid composition and uses thereof |
| US20240269263A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
| EP4680276A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Immunogenic compositions and uses thereof |
| EP4680287A1 (en) | 2023-03-15 | 2026-01-21 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| KR20250162610A (ko) | 2023-03-15 | 2025-11-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드를 포함하는 조성물 및 이의 용도 |
| EP4680595A2 (en) | 2023-03-15 | 2026-01-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2024220752A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Rna therapeutic compositions |
| WO2024220625A1 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| WO2024248422A1 (ko) * | 2023-05-26 | 2024-12-05 | 삼성바이오로직스 주식회사 | 2차 또는 3차 구조를 갖는 폴리 a 테일을 포함하는 신규 핵산 구조체 및 이의 용도 |
| WO2025006684A1 (en) | 2023-06-28 | 2025-01-02 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| WO2025042786A1 (en) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| WO2025049959A2 (en) | 2023-09-01 | 2025-03-06 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025106930A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof |
| WO2025106915A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025147583A1 (en) | 2024-01-05 | 2025-07-10 | Sail Biomedicines, Inc. | Engineered pd-1 ligands |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025160334A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN120505342A (zh) * | 2024-02-18 | 2025-08-19 | 中山大学孙逸仙纪念医院 | 一种环状多倍串联rna正义链 |
| WO2025179198A1 (en) | 2024-02-23 | 2025-08-28 | Sail Biomedicines, Inc. | Circular polyribonucleotides and unmodified linear rnas with reduced immunogenicity |
| CN118374525B (zh) * | 2024-04-22 | 2025-02-25 | 广州派真生物技术有限公司 | 一种环状rna转录载体及其制备方法和应用 |
| WO2025240680A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
| WO2026006593A1 (en) | 2024-06-28 | 2026-01-02 | Orna Therapeutics, Inc. | Synthetic internal ribosome entry sites |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| JPH06500014A (ja) | 1990-07-25 | 1994-01-06 | シンジーン，インコーポレイテッド | 多数の核酸相補体を生成させる環状伸長法 |
| US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
| US5877160A (en) | 1991-05-31 | 1999-03-02 | Genta Incorporated | Compositions and methods of treatment of androgen-associated baldness using antisense oligomers |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| CA2118806A1 (en) | 1991-09-18 | 1993-04-01 | William J. Dower | Method of synthesizing diverse collections of oligomers |
| AU683011B2 (en) | 1992-01-13 | 1997-10-30 | Duke University | Enzymatic RNA molecules |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| DE59309571D1 (de) | 1992-08-04 | 1999-06-17 | Thomson Brandt Gmbh | Hochspannungs-Zeilentransformator für einen Fernsehempfänger |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5721099A (en) | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5688997A (en) | 1994-05-06 | 1997-11-18 | Pharmacopeia, Inc. | Process for preparing intermediates for a combinatorial dihydrobenzopyran library |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| US5688696A (en) | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
| AU6180696A (en) | 1995-06-21 | 1997-01-22 | Martek Biosciences Corporation | Combinatorial libraries of labeled biochemical compounds and methods for producing same |
| US5766903A (en) * | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| CA2158237A1 (en) | 1995-09-13 | 1997-03-14 | Paolo Favaretto | Chair with a pivoting backrest |
| US5731423A (en) | 1996-03-21 | 1998-03-24 | Transcell Technologies, Inc. | Process for preparing sulfoxides |
| US6429301B1 (en) | 1998-04-17 | 2002-08-06 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| AUPR604101A0 (en) | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
| DE10132780A1 (de) | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastidäre Genexpression über autonom replizierende Vektoren |
| CA2937159C (en) | 2001-09-28 | 2017-11-28 | Thomas Tuschl | Microrna molecules |
| CA2533701A1 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| EP1664328A2 (en) | 2003-09-26 | 2006-06-07 | Circleamp, Inc. | Amplification of polynucleotides by rolling circle amplification |
| EP2514758B2 (en) | 2004-03-15 | 2021-06-23 | City of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| DE102004025881A1 (de) | 2004-05-19 | 2006-01-05 | Beiersdorf Ag | Oligoribonukleotide zur Beeinflussung des Haarwachstums |
| DE102005001784A1 (de) | 2005-01-13 | 2006-10-05 | Beiersdorf Ag | Oligoribonukleotide zur Reduktion der Schweißbildung durch RNA-Interferenz |
| FR2885808B1 (fr) | 2005-05-19 | 2007-07-06 | Oreal | Vectorisation de dsrna par des particules cationiques et utilisation topique. |
| WO2007145612A1 (en) | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
| EP1917357A2 (en) | 2005-08-01 | 2008-05-07 | Purdue Research Foundation | Multivalent rna nanoparticles for delivery of active agents to a cell |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | １本鎖環状ｒｎａおよびその製造方法 |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| EP2379083B1 (en) | 2008-12-18 | 2017-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| KR101938548B1 (ko) | 2011-06-23 | 2019-01-15 | (주)아모레퍼시픽 | 마이크로 ｒｎａ를 포함하는 색소형성유전자 발현조절용 조성물 |
| WO2013053481A1 (de) | 2011-10-11 | 2013-04-18 | Secutech International Pte. Ltd. | Dimethylsulfoxid als lösungsmittel für nukleinsäuren |
| WO2013113326A1 (en) * | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| JP6284181B2 (ja) * | 2012-02-09 | 2018-02-28 | 国立研究開発法人理化学研究所 | 環状ｒｎａ及びタンパク質の製造方法 |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| HK1206601A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| RS59199B1 (sr) | 2012-05-25 | 2019-10-31 | Univ California | Metode i jedinjenja za rnk-upravljanu ciljanu dnk modifikaciju i za rnk- upravljanu modulaciju transkripta |
| CN104769103B (zh) | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
| US20150299702A1 (en) | 2012-11-30 | 2015-10-22 | Aarhus Universitet | Circular rna for inhibition of microrna |
| EP2964234A4 (en) | 2013-03-09 | 2016-12-07 | Moderna Therapeutics Inc | Heterologous untranslated regions for mrna |
| DE102013005361A1 (de) | 2013-03-28 | 2014-10-02 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Polyribonucleotid |
| ES2746803T3 (es) | 2013-05-15 | 2020-03-06 | Robert Kruse | Traducción intracelular de ARN circular |
| EA201690403A1 (ru) | 2013-08-16 | 2016-07-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования рнк |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CA2927393A1 (en) * | 2013-10-18 | 2015-04-23 | Moderna Therapeutics, Inc. | Compositions and methods for tolerizing cellular systems |
| AU2015249553B2 (en) | 2014-04-23 | 2021-03-04 | Modernatx, Inc. | Nucleic acid vaccines |
| WO2016011222A2 (en) * | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3054017A1 (en) | 2015-02-03 | 2016-08-10 | Johann Wolfgang Goethe-Universität, Frankfurt am Main | Circular RNA for the diagnosis and treatment of cardiovascular diseases |
| AU2016236521B2 (en) | 2015-03-20 | 2019-03-07 | Unilever Global Ip Limited | Antiperspirant composition |
| AU2016271519B2 (en) | 2015-06-05 | 2021-09-02 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| US11479768B2 (en) * | 2015-06-30 | 2022-10-25 | Ethris Gmbh | ATP-binding cassette family coding polyribonucleotides and formulations thereof |
| EA201890640A1 (ru) * | 2015-09-04 | 2018-09-28 | Токаджен Инк. | Рекомбинантные векторы, содержащие пептид 2а |
| CN105664239B (zh) | 2016-03-23 | 2018-08-07 | 成都交大麦迪克科技有限公司 | 一种自粘附皮肤修复水凝胶的制备方法 |
| EP3472193A4 (en) * | 2016-06-20 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | CIRCULAR RNA AND THEIR USE IN IMMUNOMODULATION |
| CN106222174B (zh) * | 2016-08-12 | 2020-08-04 | 青岛大学 | circRNA CHIF核苷酸在治疗心脏疾病中的用途 |
| WO2018191722A1 (en) | 2017-04-14 | 2018-10-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| WO2018237372A1 (en) | 2017-06-23 | 2018-12-27 | Cornell University | RNA MOLECULES, METHODS FOR PRODUCING CIRCULAR RNA, AND METHODS OF TREATMENT |
| IL316195A (en) | 2017-12-15 | 2024-12-01 | Flagship Pioneering Innovations Vi Llc | Preparations containing circular polyribonucleotides and uses thereof |
| AU2019280583B2 (en) | 2018-06-06 | 2022-12-15 | Massachusetts Institute Of Technology | Circular RNA for translation in eukaryotic cells |
| BR112021001343A2 (pt) | 2018-07-24 | 2021-05-04 | Flagship Pioneering Innovations Vi, Llc | composições compreendendo poliribonucleotídeos circulares e seus usos |
| CN111603477B (zh) | 2019-02-25 | 2023-06-02 | 中国科学院分子细胞科学卓越创新中心 | 环形rna在系统性红斑狼疮制备治疗药物中的应用 |
| JP7614108B2 (ja) | 2019-03-01 | 2025-01-15 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ポリリボヌクレオチド及びその化粧用の使用 |
| WO2020180751A1 (en) | 2019-03-01 | 2020-09-10 | Flagship Pioneering Innovations Vi, Llc | Compositions, methods, and kits for delivery of polyribonucleotides |
| WO2020181013A1 (en) | 2019-03-04 | 2020-09-10 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides and pharmaceutical compositions thereof |
| CN113661242A (zh) | 2019-03-25 | 2021-11-16 | 旗舰创业创新第六有限责任公司 | 包含经修饰的环状多核糖核苷酸的组合物及其用途 |
| JP7686574B2 (ja) | 2019-05-22 | 2025-06-02 | マサチューセッツ インスティテュート オブ テクノロジー | 環状ｒｎａ組成物及び方法 |
| JP2022537154A (ja) | 2019-06-14 | 2022-08-24 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 細胞治療のための環状ｒｎａ |
| US20220305128A1 (en) | 2019-06-19 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
| JP2022536951A (ja) | 2019-06-19 | 2022-08-22 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 環状ポリリボヌクレオチドを投与する方法 |
| WO2021155171A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Delivery of compositions comprising circular polyribonucleotides |
| CN115361954A (zh) | 2020-01-29 | 2022-11-18 | 旗舰创业创新第六有限责任公司 | 用于翻译的组合物及其使用方法 |
| CN115279415A (zh) | 2020-01-29 | 2022-11-01 | 旗舰创业创新第六有限责任公司 | 用于蛋白调节的包含线性多核糖核苷酸的组合物及其用途 |
| US20230203192A1 (en) | 2020-05-20 | 2023-06-29 | Flagship Pioneering, Inc. | Compositions and methods for producing human polyclonal antibodies |
| IL298363A (en) | 2020-05-20 | 2023-01-01 | Flagship Pioneering Innovations Vi Llc | Immunogenic compositions and uses thereof |
| CA3179420A1 (en) | 2020-05-20 | 2021-11-25 | Avak Kahvejian | Coronavirus antigen compositions and their uses |
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