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MX2020004444A - Integracion genica direccionada de genes de inhibidores de nk para terapia con celulas inmunes mejorada. - Google Patents

Integracion genica direccionada de genes de inhibidores de nk para terapia con celulas inmunes mejorada.

Info

Publication number
MX2020004444A
MX2020004444A MX2020004444A MX2020004444A MX2020004444A MX 2020004444 A MX2020004444 A MX 2020004444A MX 2020004444 A MX2020004444 A MX 2020004444A MX 2020004444 A MX2020004444 A MX 2020004444A MX 2020004444 A MX2020004444 A MX 2020004444A
Authority
MX
Mexico
Prior art keywords
immune cell
cell therapy
enhanced immune
gene integration
directed gene
Prior art date
Application number
MX2020004444A
Other languages
English (en)
Inventor
Brian Busser
Philippe Duchateau
Alexandre Juillerat
Laurent Poirot
Julien Valton
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2017/076798 external-priority patent/WO2018073391A1/en
Application filed by Cellectis filed Critical Cellectis
Publication of MX2020004444A publication Critical patent/MX2020004444A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

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  • Immunology (AREA)
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  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invención pertenece al campo de la inmunoterapia celular adaptativa. Proporciona la inserción genética de secuencias de codificación exógenas que ayudan a las células inmunes a dirigir su respuesta inmune contra células infectadas o malignas. Estas secuencias de codificación exógenas se insertan más particularmente bajo el control transcripcional de promotores génicos endógenos que son sensibles a la activación por células inmunes. Tal método permite la producción de células primarias inmunes más seguras de mayor potencial terapéutico.
MX2020004444A 2017-10-19 2018-03-09 Integracion genica direccionada de genes de inhibidores de nk para terapia con celulas inmunes mejorada. MX2020004444A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2017/076798 WO2018073391A1 (en) 2016-10-19 2017-10-19 Targeted gene insertion for improved immune cells therapy
EP2018053343 2018-02-09
PCT/EP2018/055957 WO2019076486A1 (en) 2017-10-19 2018-03-09 TARGETED GENE INTEGRATION OF NK INHIBITOR GENES FOR ENHANCED IMMUNE CELL THERAPY

Publications (1)

Publication Number Publication Date
MX2020004444A true MX2020004444A (es) 2020-07-22

Family

ID=66173541

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004444A MX2020004444A (es) 2017-10-19 2018-03-09 Integracion genica direccionada de genes de inhibidores de nk para terapia con celulas inmunes mejorada.

Country Status (10)

Country Link
US (2) US12209125B2 (es)
EP (2) EP3684919A1 (es)
JP (2) JP7621795B2 (es)
KR (2) KR20200075851A (es)
CN (1) CN111511903B (es)
AU (2) AU2018353112B2 (es)
CA (1) CA3084476A1 (es)
IL (1) IL273828B2 (es)
MX (1) MX2020004444A (es)
WO (2) WO2019076486A1 (es)

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