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MX2020003561A - Inhibicion de la hsd17b13 en el tratamiento de la enfermedad hepatica en pacientes que expresan la variacion pnpla3 i148m. - Google Patents

Inhibicion de la hsd17b13 en el tratamiento de la enfermedad hepatica en pacientes que expresan la variacion pnpla3 i148m.

Info

Publication number
MX2020003561A
MX2020003561A MX2020003561A MX2020003561A MX2020003561A MX 2020003561 A MX2020003561 A MX 2020003561A MX 2020003561 A MX2020003561 A MX 2020003561A MX 2020003561 A MX2020003561 A MX 2020003561A MX 2020003561 A MX2020003561 A MX 2020003561A
Authority
MX
Mexico
Prior art keywords
hsd17b13
liver disease
pnpla3
treatment
disclosure
Prior art date
Application number
MX2020003561A
Other languages
English (en)
Inventor
Xiping Cheng
Yurong Xin
Frederick Dewey
Jesper Gromada
Dostal Tanya Teslovich
Claudia Schurmann
Noura Abul-Husn
Aris Baras
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64316974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020003561(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020003561A publication Critical patent/MX2020003561A/es

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Hospice & Palliative Care (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La descripción proporciona métodos para identificar a un sujeto humano como candidato para el tratamiento o la inhibición de una enfermedad hepática mediante la inhibición de la HSD17B13. La descripción también proporciona métodos para tratar a un sujeto que es PNPLA3 Ile148Met+ mediante la administración de un inhibidor de la HSD17B13. La descripción también proporciona un método de detección de una variante PNPLA3 Ile148Met y HSD17B13 funcional en un sujeto. La descripción también proporciona un método para identificar a un sujeto que tiene un efecto protector contra la enfermedad hepática. La descripción también proporciona inhibidores de la HSD17B13 para su uso en el tratamiento de una enfermedad hepática.
MX2020003561A 2017-10-11 2018-10-11 Inhibicion de la hsd17b13 en el tratamiento de la enfermedad hepatica en pacientes que expresan la variacion pnpla3 i148m. MX2020003561A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762570985P 2017-10-11 2017-10-11
PCT/US2018/055377 WO2019075181A1 (en) 2017-10-11 2018-10-11 INHIBITION OF HSD17B13 IN THE TREATMENT OF HEPATIC DISEASE IN PATIENTS EXPRESSING PNPLA3 I148M VARIATION

Publications (1)

Publication Number Publication Date
MX2020003561A true MX2020003561A (es) 2020-08-03

Family

ID=64316974

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003561A MX2020003561A (es) 2017-10-11 2018-10-11 Inhibicion de la hsd17b13 en el tratamiento de la enfermedad hepatica en pacientes que expresan la variacion pnpla3 i148m.

Country Status (12)

Country Link
US (4) US10961583B2 (es)
EP (2) EP4234719B1 (es)
JP (2) JP7434151B2 (es)
KR (2) KR102694809B1 (es)
CN (1) CN111183234A (es)
AU (2) AU2018348195B2 (es)
CA (1) CA3078883A1 (es)
IL (2) IL319615A (es)
MX (1) MX2020003561A (es)
RU (1) RU2020115526A (es)
SG (1) SG11202003254SA (es)
WO (1) WO2019075181A1 (es)

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CN114262738B (zh) * 2021-12-31 2023-03-31 吉林大学第一医院 Hsd17b13基因多态性在中重度mafld诊断中的应用
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