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MX2020003082A - Metodos para inhibir la conversion de colina en trimetilamina (tma). - Google Patents

Metodos para inhibir la conversion de colina en trimetilamina (tma).

Info

Publication number
MX2020003082A
MX2020003082A MX2020003082A MX2020003082A MX2020003082A MX 2020003082 A MX2020003082 A MX 2020003082A MX 2020003082 A MX2020003082 A MX 2020003082A MX 2020003082 A MX2020003082 A MX 2020003082A MX 2020003082 A MX2020003082 A MX 2020003082A
Authority
MX
Mexico
Prior art keywords
tma
trimethylamine
choline
methods
inhibiting conversion
Prior art date
Application number
MX2020003082A
Other languages
English (en)
Other versions
MX390468B (es
Inventor
John August Wos
Jose Carlos Garcia-Garcia
George Franklin Gerberick
Stanley Leon HAZEN
Xiaodong Gu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX2020003082A publication Critical patent/MX2020003082A/es
Publication of MX390468B publication Critical patent/MX390468B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método para inhibir la conversión de colina en trimetilamina (TMA) y reducir la TMAO en un individuo al proporcionar una composición que comprende un compuesto expuesto en la Fórmula (I): (ver Fórmula).
MX2020003082A 2017-10-02 2018-10-02 Metodos para inhibir la conversion de colina en trimetilamina (tma) MX390468B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762566992P 2017-10-02 2017-10-02
PCT/US2018/053926 WO2019070677A1 (en) 2017-10-02 2018-10-02 METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA)

Publications (2)

Publication Number Publication Date
MX2020003082A true MX2020003082A (es) 2022-03-07
MX390468B MX390468B (es) 2025-03-20

Family

ID=63963528

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003082A MX390468B (es) 2017-10-02 2018-10-02 Metodos para inhibir la conversion de colina en trimetilamina (tma)

Country Status (9)

Country Link
US (1) US10675256B2 (es)
EP (1) EP3522878B1 (es)
CN (1) CN111163765B (es)
AU (1) AU2018345748B2 (es)
BR (1) BR112020006121B1 (es)
CA (1) CA3076232C (es)
MX (1) MX390468B (es)
PL (1) PL3522878T3 (es)
WO (1) WO2019070677A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019374794B2 (en) 2018-11-06 2022-09-08 The Cleveland Clinic Foundation Methods for inhibiting conversion of choline to trimethylamine (TMA)
AU2019392924A1 (en) * 2018-12-06 2021-06-17 Senda Biosciences, Inc Quaternary ammonium salts as inhibitors of trimethylamine production

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542826B1 (de) 1966-06-01 1971-04-08 Basf Ag Sulfoniumverbindungen und deren Verwendung
FR1559102A (es) * 1968-01-23 1969-03-07
US3644531A (en) 1968-08-13 1972-02-22 Sankyo Co 2-propynylsulfonium salts
US3651222A (en) 1969-09-15 1972-03-21 Monsanto Co Nematocidal use of substituted dimethylsulfonium tetraphenylborates
DE2331185A1 (de) 1973-06-19 1975-01-16 Bayer Ag Mittel zur regulierung des pflanzenwachstums
EP0555058B1 (en) 1992-02-07 1997-05-07 Toyo Ink Manufacturing Co., Ltd. (Oxo)sulfonium complex, polymerizable composition containing the complex, and method of polymerizing composition
JP4999043B2 (ja) * 2006-02-13 2012-08-15 株式会社Ａｄｅｋａ スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物
CN104582507A (zh) 2012-06-11 2015-04-29 克利夫兰诊所基金会 心血管疾病和血栓形成的治疗与预防
MX378437B (es) 2015-12-01 2025-03-11 Procter & Gamble Compuestos y métodos para inhibir la producción de trimetilamina.
CA3028379C (en) 2016-06-29 2021-10-26 The Procter & Gamble Company Methods for inhibiting conversion of choline to trimethylamine (tma)

Also Published As

Publication number Publication date
PL3522878T3 (pl) 2021-08-23
AU2018345748B2 (en) 2021-03-18
BR112020006121A2 (pt) 2020-09-24
BR112020006121B1 (pt) 2022-05-24
CA3076232A1 (en) 2019-04-11
MX390468B (es) 2025-03-20
EP3522878A1 (en) 2019-08-14
CN111163765B (zh) 2023-05-09
US10675256B2 (en) 2020-06-09
CN111163765A (zh) 2020-05-15
US20190099389A1 (en) 2019-04-04
WO2019070677A1 (en) 2019-04-11
CA3076232C (en) 2023-05-16
AU2018345748A1 (en) 2020-04-09
EP3522878B1 (en) 2021-03-31

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