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MX2020002925A - Nucleósidos sustituidos, nucleótidos y análogos de estos. - Google Patents

Nucleósidos sustituidos, nucleótidos y análogos de estos.

Info

Publication number
MX2020002925A
MX2020002925A MX2020002925A MX2020002925A MX2020002925A MX 2020002925 A MX2020002925 A MX 2020002925A MX 2020002925 A MX2020002925 A MX 2020002925A MX 2020002925 A MX2020002925 A MX 2020002925A MX 2020002925 A MX2020002925 A MX 2020002925A
Authority
MX
Mexico
Prior art keywords
nucleotides
analogs
substituted nucleosides
compounds
formula
Prior art date
Application number
MX2020002925A
Other languages
English (en)
Inventor
Leonid Beigelman
Jerome Deval
Marija Prhavc
Original Assignee
Janssen Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biopharma Inc filed Critical Janssen Biopharma Inc
Publication of MX2020002925A publication Critical patent/MX2020002925A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En la presente descripción se describen compuestos de la Fórmula (I) y sales farmacéuticamente aceptables de estos: (ver fórmula) donde las variables en la Fórmula (I) se describen en la presente descripción. También se describen métodos para sintetizar tales compuestos y métodos para usarlos para tratar enfermedades y/o afecciones tales como infecciones virales por Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae y/o Coronaviridae.
MX2020002925A 2017-09-18 2018-09-18 Nucleósidos sustituidos, nucleótidos y análogos de estos. MX2020002925A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762560110P 2017-09-18 2017-09-18
PCT/IB2018/057188 WO2019053696A1 (en) 2017-09-18 2018-09-18 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Publications (1)

Publication Number Publication Date
MX2020002925A true MX2020002925A (es) 2020-10-05

Family

ID=63794555

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002925A MX2020002925A (es) 2017-09-18 2018-09-18 Nucleósidos sustituidos, nucleótidos y análogos de estos.

Country Status (17)

Country Link
US (2) US11149049B2 (es)
EP (1) EP3684782A1 (es)
JP (1) JP2020534361A (es)
KR (1) KR102696517B1 (es)
CN (1) CN111542531B (es)
AU (1) AU2018332540B2 (es)
CA (1) CA3075950A1 (es)
CL (1) CL2020000685A1 (es)
CR (1) CR20200126A (es)
EA (1) EA202090775A1 (es)
EC (1) ECSP20022130A (es)
IL (1) IL273341A (es)
MA (1) MA50172A (es)
MX (1) MX2020002925A (es)
PH (1) PH12020550114A1 (es)
SG (1) SG11202002295QA (es)
WO (1) WO2019053696A1 (es)

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Also Published As

Publication number Publication date
JP2020534361A (ja) 2020-11-26
BR112020005177A2 (pt) 2020-09-15
CR20200126A (es) 2020-07-11
MA50172A (fr) 2021-04-07
CN111542531A (zh) 2020-08-14
EP3684782A1 (en) 2020-07-29
CA3075950A1 (en) 2019-03-21
KR20200098483A (ko) 2020-08-20
US20210395288A1 (en) 2021-12-23
US20200277321A1 (en) 2020-09-03
AU2018332540A1 (en) 2020-04-30
CN111542531B (zh) 2024-07-19
ECSP20022130A (es) 2020-07-31
EA202090775A1 (ru) 2020-07-06
US11773126B2 (en) 2023-10-03
US11149049B2 (en) 2021-10-19
KR102696517B1 (ko) 2024-08-21
AU2018332540B2 (en) 2023-10-05
PH12020550114A1 (en) 2020-12-07
SG11202002295QA (en) 2020-04-29
IL273341A (en) 2020-05-31
WO2019053696A1 (en) 2019-03-21
CL2020000685A1 (es) 2020-10-23

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