MX2020001979A - Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma. - Google Patents
Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma.Info
- Publication number
- MX2020001979A MX2020001979A MX2020001979A MX2020001979A MX2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidine
- pharmaceutical composition
- macrocycle containing
- aminopyrazole
- containing aminopyrazole
- Prior art date
Links
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical compound NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 108091005682 Receptor kinases Proteins 0.000 abstract 1
- 102000005937 Tropomyosin Human genes 0.000 abstract 1
- 108010030743 Tropomyosin Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud se refiere a un macrociclo que contiene aminopirazol y pirimidina, que está representado por la fórmula (I), a una composición farmacéutica del mismo y a su uso en la inhibición de la actividad de la quinasa del receptor de tropomiosina (Trk) y en el tratamiento de enfermedades en mamíferos que están mediadas por Trk (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710728132 | 2017-08-23 | ||
| PCT/CN2018/101960 WO2019037761A1 (zh) | 2017-08-23 | 2018-08-23 | 含有氨基吡唑并嘧啶的大环化合物及其药物组合物和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020001979A true MX2020001979A (es) | 2020-03-24 |
Family
ID=65439377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020001979A MX2020001979A (es) | 2017-08-23 | 2018-08-23 | Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11098060B2 (es) |
| EP (1) | EP3674307B1 (es) |
| JP (1) | JP7239563B2 (es) |
| KR (1) | KR102619444B1 (es) |
| CN (2) | CN110945000B (es) |
| AU (1) | AU2018320021C1 (es) |
| BR (1) | BR112020003783A2 (es) |
| CA (1) | CA3071032A1 (es) |
| DK (1) | DK3674307T3 (es) |
| ES (1) | ES2951427T3 (es) |
| FI (1) | FI3674307T3 (es) |
| MX (1) | MX2020001979A (es) |
| PL (1) | PL3674307T3 (es) |
| WO (1) | WO2019037761A1 (es) |
| ZA (1) | ZA202001442B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019094143A1 (en) * | 2017-11-10 | 2019-05-16 | Angex Pharmaceutical, Inc. | Macrocyclic compounds as trk kinase inhibitors and uses thereof |
| JP7092405B2 (ja) | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| EP4480953B1 (en) | 2018-10-22 | 2026-02-04 | Alumis Inc. | Tyk2 inhibitors and uses thereof |
| JP7318009B2 (ja) * | 2019-05-21 | 2023-07-31 | 浙江海正薬業股▲ふん▼有限公司 | マクロライド誘導体、その製造方法および用途 |
| CN112110938B (zh) * | 2019-06-21 | 2021-11-09 | 成都海博为药业有限公司 | 一种作为蛋白质激酶抑制剂的化合物及其制备方法和用途 |
| CN111875620B (zh) * | 2020-09-28 | 2020-12-11 | 上海美迪西生物医药股份有限公司 | 吡唑并嘧啶类大环衍生物及其应用 |
| KR102889677B1 (ko) * | 2020-11-03 | 2025-11-21 | 주식회사 엘지화학 | 작물보호제용 신규 화합물 |
| CN114907379A (zh) * | 2021-02-06 | 2022-08-16 | 正大天晴药业集团股份有限公司 | 作为egfr激酶抑制剂的大环化合物 |
| CN113475740B (zh) * | 2021-07-10 | 2022-10-21 | 深圳市真味生物科技有限公司 | 一种手性合成尼古丁的制备方法 |
| WO2023025141A1 (zh) * | 2021-08-23 | 2023-03-02 | 正大天晴药业集团股份有限公司 | 含有氨基的大环化合物在治疗trk激酶介导的肿瘤中的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| PT3372605T (pt) | 2008-10-22 | 2021-12-09 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk |
| SMT201900203T1 (it) * | 2010-05-20 | 2019-05-10 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| BR112013021638A2 (pt) | 2011-02-25 | 2016-08-02 | Irm Llc | "compostos inibidores de trk, seu uso e composições que os compreendem" |
| EP3317285B1 (en) * | 2015-07-02 | 2021-01-27 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| BR112018003588A2 (pt) | 2015-08-26 | 2018-09-25 | Blueprint Medicines Corp | compostos e composições úteis para tratamento de distúrbios relacionados ao ntrk |
| ES2896943T3 (es) | 2016-10-28 | 2022-02-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Compuesto de amino pirazolopirimidina usado como inhibidor de receptores con actividad tirosina quinasa de factores neurotróficos |
-
2018
- 2018-08-23 AU AU2018320021A patent/AU2018320021C1/en active Active
- 2018-08-23 ES ES18849368T patent/ES2951427T3/es active Active
- 2018-08-23 FI FIEP18849368.8T patent/FI3674307T3/fi active
- 2018-08-23 BR BR112020003783-4A patent/BR112020003783A2/pt unknown
- 2018-08-23 US US16/641,187 patent/US11098060B2/en active Active
- 2018-08-23 PL PL18849368.8T patent/PL3674307T3/pl unknown
- 2018-08-23 EP EP18849368.8A patent/EP3674307B1/en active Active
- 2018-08-23 DK DK18849368.8T patent/DK3674307T3/da active
- 2018-08-23 KR KR1020207008187A patent/KR102619444B1/ko active Active
- 2018-08-23 WO PCT/CN2018/101960 patent/WO2019037761A1/zh not_active Ceased
- 2018-08-23 CN CN201880053972.3A patent/CN110945000B/zh active Active
- 2018-08-23 CA CA3071032A patent/CA3071032A1/en active Pending
- 2018-08-23 MX MX2020001979A patent/MX2020001979A/es unknown
- 2018-08-23 JP JP2020511268A patent/JP7239563B2/ja active Active
- 2018-08-23 CN CN202111098325.4A patent/CN113735881A/zh active Pending
-
2020
- 2020-03-06 ZA ZA2020/01442A patent/ZA202001442B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018320021A1 (en) | 2020-03-12 |
| CN113735881A (zh) | 2021-12-03 |
| WO2019037761A1 (zh) | 2019-02-28 |
| ES2951427T3 (es) | 2023-10-20 |
| ZA202001442B (en) | 2022-04-28 |
| FI3674307T3 (fi) | 2023-09-11 |
| CN110945000B (zh) | 2021-09-03 |
| US11098060B2 (en) | 2021-08-24 |
| AU2018320021B2 (en) | 2022-04-21 |
| EP3674307A4 (en) | 2021-04-28 |
| AU2018320021C1 (en) | 2023-02-23 |
| KR102619444B1 (ko) | 2023-12-29 |
| KR20200044062A (ko) | 2020-04-28 |
| EP3674307B1 (en) | 2023-06-07 |
| JP7239563B2 (ja) | 2023-03-14 |
| US20200291042A1 (en) | 2020-09-17 |
| JP2021501738A (ja) | 2021-01-21 |
| RU2020108770A3 (es) | 2022-02-28 |
| BR112020003783A2 (pt) | 2020-09-01 |
| CA3071032A1 (en) | 2019-02-28 |
| DK3674307T3 (da) | 2023-09-11 |
| RU2020108770A (ru) | 2021-09-23 |
| EP3674307A1 (en) | 2020-07-01 |
| PL3674307T3 (pl) | 2023-11-27 |
| CN110945000A (zh) | 2020-03-31 |
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