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MX2019015283A - Dispositivos difusores de luz para su uso en fotoimmunoterapia. - Google Patents

Dispositivos difusores de luz para su uso en fotoimmunoterapia.

Info

Publication number
MX2019015283A
MX2019015283A MX2019015283A MX2019015283A MX2019015283A MX 2019015283 A MX2019015283 A MX 2019015283A MX 2019015283 A MX2019015283 A MX 2019015283A MX 2019015283 A MX2019015283 A MX 2019015283A MX 2019015283 A MX2019015283 A MX 2019015283A
Authority
MX
Mexico
Prior art keywords
core
light
fiber
diffusing
section
Prior art date
Application number
MX2019015283A
Other languages
English (en)
Other versions
MX376819B (es
Inventor
Rose Andreas
Johnston Kyle
Biel Merrill
Original Assignee
Rakuten Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rakuten Medical Inc filed Critical Rakuten Medical Inc
Publication of MX2019015283A publication Critical patent/MX2019015283A/es
Publication of MX376819B publication Critical patent/MX376819B/es

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0005Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
    • G02B6/0008Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type the light being emitted at the end of the fibre
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/067Radiation therapy using light using laser light
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407Optical details
    • G02B23/2461Illumination
    • G02B23/2469Illumination using optical fibres
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0927Systems for changing the beam intensity distribution, e.g. Gaussian to top-hat
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/02Diffusing elements; Afocal elements
    • G02B5/0205Diffusing elements; Afocal elements characterised by the diffusing properties
    • G02B5/021Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0005Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
    • G02B6/001Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type the light being emitted along at least a portion of the lateral surface of the fibre
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02Optical fibres with cladding with or without a coating
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02Optical fibres with cladding with or without a coating
    • G02B6/02295Microstructured optical fibre
    • G02B6/02314Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02Optical fibres with cladding with or without a coating
    • G02B6/036Optical fibres with cladding with or without a coating core or cladding comprising multiple layers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/26Optical coupling means
    • G02B6/262Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2035Beam shaping or redirecting; Optical components therefor
    • A61B2018/20554Arrangements for particular intensity distribution, e.g. tophat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N2005/0612Apparatus for use inside the body using probes penetrating tissue; interstitial probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/063Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0664Details
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/02Diffusing elements; Afocal elements
    • G02B5/0205Diffusing elements; Afocal elements characterised by the diffusing properties
    • G02B5/021Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures
    • G02B5/0221Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures the surface having an irregular structure
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/02Diffusing elements; Afocal elements
    • G02B5/0205Diffusing elements; Afocal elements characterised by the diffusing properties
    • G02B5/021Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures
    • G02B5/0226Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures having particles on the surface
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/241Light guide terminations

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Light Guides In General And Applications Therefor (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Radiation-Therapy Devices (AREA)
  • Artificial Filaments (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

La presente invención proporciona un dispositivo difusor de luz cilíndrico (300) que comprende una fibra de núcleo no circular (302) que tiene (i) un núcleo de la fibra (350) que proporciona una distribución de irradiancia del núcleo de "sombrero de copa"; opcionalmente (ii) un medio de bloqueo de luz (314) que evitan la emisión de luz frontal desde extremo distal de la fibra de núcleo no circular (302); y (iii) una sección difusora de luz (308) que tiene un extremo proximal difusor (310), un extremo distal difusor (312) y características de dispersión interna(362) distribuidas dentro del núcleo de la fibra (350) de la sección difusora de luz (308) a lo largo del eje central (364) del núcleo de la fibra (350), en donde la sección difusión de la luz (308) emite irradiancia en una distribución de irradiancia difusora radialmente simétrica longitudinalmente de "sombrero de copa". La descripción también proporciona un dispositivo (600) que comprende una sección de fibra de núcleo no circular (604) y una lente (606), en donde la sección núcleo no circular tiene una distribución de irradiancia del núcleo de "sombrero de copa" y el dispositivo proporciona una distribución de irradiancia espectral "de sombrero de copa" en una ubicación focalizada. La descripción también proporciona un dispositivo (700) que comprende una fibra óptica (702) y un conjunto de lentes de colimación (704) que incluye una abertura variable (714) que bloquea porciones de la luz descompuestas de la fibra óptica permitiendo de esta manera que solo una porción central de la luz salga de la abertura variable que da como resultado una distribución de irradiancia plana.
MX2019015283A 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia MX376819B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662412606P 2016-10-25 2016-10-25
US201762529507P 2017-07-07 2017-07-07
PCT/US2017/057787 WO2018080952A1 (en) 2016-10-25 2017-10-23 Light diffusing devices for use in photoimmunotherapy

Publications (2)

Publication Number Publication Date
MX2019015283A true MX2019015283A (es) 2020-02-13
MX376819B MX376819B (es) 2025-03-07

Family

ID=60473584

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019015283A MX376819B (es) 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia
MX2019015282A MX376820B (es) 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia
MX2019004391A MX371235B (es) 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2019015282A MX376820B (es) 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia
MX2019004391A MX371235B (es) 2016-10-25 2017-10-23 Dispositivos difusores de luz para su uso en fotoimmunoterapia

Country Status (12)

Country Link
US (3) US10527771B2 (es)
EP (2) EP3532771A1 (es)
JP (3) JP6688940B2 (es)
KR (3) KR102103127B1 (es)
CN (2) CN111035858B (es)
AU (3) AU2017351052B2 (es)
BR (2) BR122020013058B1 (es)
CA (3) CA3070469C (es)
MX (3) MX376819B (es)
RU (2) RU2740793C2 (es)
SG (2) SG11201903062TA (es)
WO (1) WO2018080952A1 (es)

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