[go: up one dir, main page]

MX2019014829A - Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. - Google Patents

Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas.

Info

Publication number
MX2019014829A
MX2019014829A MX2019014829A MX2019014829A MX2019014829A MX 2019014829 A MX2019014829 A MX 2019014829A MX 2019014829 A MX2019014829 A MX 2019014829A MX 2019014829 A MX2019014829 A MX 2019014829A MX 2019014829 A MX2019014829 A MX 2019014829A
Authority
MX
Mexico
Prior art keywords
multivalent conjugate
linkers
capsular polysaccharides
bivalent
bifunctional
Prior art date
Application number
MX2019014829A
Other languages
English (en)
Inventor
Subhash V Kapre
Anup K Datta
Original Assignee
Inventprise Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inventprise Llc filed Critical Inventprise Llc
Publication of MX2019014829A publication Critical patent/MX2019014829A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La descripción describe composiciones que contienen conjugados utilizando enlazadores novedosos, conjugados de polisacárido bivalentes y métodos de conjugación de polisacárido bivalente en el desarrollo de vacunas de conjugados multivalentes. La conjugación de polisacáridos capsulares a proteinas portadoras se lleva a cabo utilizando enlazadores homobifuncionales y/o heterobifuncionales de longitudes específicas. La incorporación de los enlazadores y su uso en enlazadores bifuncionales induce títulos más altos de anticuerpos funcionales con alta avidez, produciendo una memoria inmunológica superior y un efecto de proteína portadora reducido. Esto proporciona polisacáridos capsulares de reacción cruzada inmunológica, en donde uno o más polisacáridos capsulares de reacción cruzada se conjugan secuencial o concurrentemente a la proteína portadora utilizando enlazadores bifuncionales que llevan los mismos grupos funcionales o unos diferentes. Dicho enlazador y el tamaño de los polisacáridos capsulares proporcionan una vacuna de conjugado multivalente efectiva con altos títulos de anticuerpo y un efecto reducido de portadora y da como resultado una reducción en el contenido del polisacárido capsular y proteína por dosis de vacuna lo cual reduce la reactogenicidad.
MX2019014829A 2017-06-10 2018-06-11 Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. MX2019014829A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762517905P 2017-06-10 2017-06-10
PCT/US2018/036868 WO2018227177A1 (en) 2017-06-10 2018-06-11 Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity

Publications (1)

Publication Number Publication Date
MX2019014829A true MX2019014829A (es) 2020-08-17

Family

ID=64562792

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019014829A MX2019014829A (es) 2017-06-10 2018-06-11 Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas.
MX2023009362A MX2023009362A (es) 2017-06-10 2019-12-09 Vacunas de conjugado multivalente con polisacaridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023009362A MX2023009362A (es) 2017-06-10 2019-12-09 Vacunas de conjugado multivalente con polisacaridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas.

Country Status (12)

Country Link
US (1) US10688170B2 (es)
EP (1) EP3634481A4 (es)
JP (1) JP7132954B2 (es)
KR (3) KR20240018697A (es)
CN (2) CN118356485A (es)
AU (1) AU2018280272C1 (es)
BR (1) BR112019026192B1 (es)
CA (1) CA3066911C (es)
MX (2) MX2019014829A (es)
MY (1) MY198400A (es)
WO (1) WO2018227177A1 (es)
ZA (1) ZA201908528B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016168815A1 (en) * 2015-04-16 2016-10-20 Iventprise LLC Bordetella pertussis immunogenic vaccine compositions
KR20210027523A (ko) * 2015-07-21 2021-03-10 화이자 인코포레이티드 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도
US10729763B2 (en) * 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
CN118356485A (zh) 2017-06-10 2024-07-19 创赏公司 提供改善的免疫原性和亲合力的具有二价或多价缀合物多糖的多价缀合物疫苗
SG11202005255PA (en) 2017-12-06 2020-07-29 Merck Sharp & Dohme Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
WO2020121159A1 (en) * 2018-12-12 2020-06-18 Pfizer Inc. Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof
JOP20210148A1 (ar) 2018-12-19 2023-01-30 Merck Sharp & Dohme تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها
AU2020286360A1 (en) * 2019-06-05 2021-12-23 Merck Sharp & Dohme Llc An immunogenic serotype 35B pneumococcal polysaccharide-protein conjugate and conjugation process for making the same
CN110804097B (zh) * 2019-10-30 2021-02-26 云南沃森生物技术股份有限公司 一种同时制备两种单克隆抗体的方法
AU2021207701B2 (en) * 2020-01-17 2025-08-14 Bill & Melinda Gates Foundation Multivalent Streptococcus vaccines
CN111643661A (zh) * 2020-06-08 2020-09-11 王竹林 新型免疫佐剂、化合物及其应用
CA3191005A1 (en) * 2020-08-10 2022-02-17 Inventprise, Inc. Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f
CN116744965A (zh) * 2020-11-04 2023-09-12 辉瑞大药厂 用于肺炎球菌疫苗的免疫原性组合物
CN113173977B (zh) * 2021-05-12 2024-03-29 江苏坤力生物制药有限责任公司 一种双功能抗原、其制备方法及应用
CN115721709A (zh) * 2021-08-27 2023-03-03 康希诺生物股份公司 一种肺炎球菌结合疫苗制备方法
GB2614916A (en) * 2022-01-25 2023-07-26 Optivalent Ltd Intradermal vaccine complement
AU2023235760A1 (en) * 2022-03-18 2024-10-24 Denka Company Limited Virus-like particle containing capsid proteins connected by linker.
CN117643624A (zh) * 2024-01-30 2024-03-05 成都康华生物制品股份有限公司 一种双价多糖结合疫苗的制备方法及双价多糖结合疫苗

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360897A (en) 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4902506A (en) 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4686102A (en) 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof
CA2059692C (en) 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
CA2059693C (en) 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
US5371197A (en) 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5849301A (en) 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5681570A (en) 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
US5866132A (en) 1995-06-07 1999-02-02 Alberta Research Council Immunogenic oligosaccharide compositions
FR2763244B1 (fr) 1997-05-14 2003-08-01 Pasteur Merieux Serums Vacc Composition vaccinale multivalente a porteur mixte
US6224880B1 (en) 1997-09-24 2001-05-01 Merck & Co., Inc. Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines
US5965714A (en) 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
US6903184B1 (en) 1998-03-02 2005-06-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multiple antigenic peptides immunogenic against Streptococcus pneumonia
KR100794394B1 (ko) 1998-04-07 2008-01-15 메디뮨 인코포레이티드 백신용 폐렴 구균의 콜린 결합성 단백질의 유도체
EP1034792A1 (en) 1999-03-11 2000-09-13 Pasteur Merieux Serums Et Vaccins Intranasal delivery of pneumococcal polysaccharide vaccines
DE122009000054I1 (de) 1999-03-19 2009-12-31 Glaxosmithkline Biolog Sa Impfstoff gegen bakterielle antigene
FR2806304B1 (fr) 2000-03-17 2002-05-10 Aventis Pasteur Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0130215D0 (en) 2001-12-18 2002-02-06 Glaxosmithkline Biolog Sa Vaccine
WO2003094960A2 (en) 2002-05-14 2003-11-20 Chiron Srl Mucosal combination vaccines for bacterial meningitis
AU2003245648A1 (en) 2002-06-20 2004-01-06 University Of Maryland Biotechnology Institute Scaffolded maleimide clusters for multivalent peptide assembly
US20040096461A1 (en) * 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
KR101052996B1 (ko) 2003-03-13 2011-07-29 글락소스미스클라인 바이오로지칼즈 에스.에이. 박테리아 세포용해소에 대한 정제 공정
US8048432B2 (en) 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
CA2535043A1 (en) 2003-08-06 2005-04-28 Ellen Jessouroun Process for preparing polysaccharide-protein conjugate vaccines
US20050118199A1 (en) 2003-10-07 2005-06-02 Esser Mark T. Process for covalently conjugating polysaccharides to microspheres or biomolecules
EP1781326A4 (en) * 2004-06-04 2009-01-14 Pharmexa Inc INDUCTION OF AN IMMUNE RESPONSE AGAINST STREPTOCOKE PENUMONIA POLYSACCHARIDES
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
DK1868645T3 (da) 2005-04-08 2012-04-10 Wyeth Llc Multivalent pneumokok-sakkarid-protein-konjugat-sammensætning
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20070184072A1 (en) 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
US7955605B2 (en) * 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
AU2006286228A1 (en) 2005-09-01 2007-03-08 Novartis Vaccines And Diagnostics Gmbh & Co Kg Multiple vaccination including serogroup C meningococcus
KR101441368B1 (ko) 2005-12-22 2014-09-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 폐렴구균 다당류 컨쥬게이트 백신
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
DK1976974T3 (da) 2005-12-28 2014-09-15 Uab Research Foundation Pneumokok-serotyper.
US8481054B2 (en) 2005-12-28 2013-07-09 The UAB Foundation Pneumococcal serotypes
US8575319B2 (en) 2006-03-10 2013-11-05 The Regents Of The University Of California Cleavable vaccine compositions and uses thereof and methods of making and using the same
KR20130135399A (ko) 2006-03-17 2013-12-10 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 복합 다가 면역원성 콘쥬게이트의 제조 방법
AR060187A1 (es) 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa Composicion inmunogenica
WO2007127668A2 (en) 2006-04-26 2007-11-08 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
WO2008021076A2 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Protein matrix vaccines and methods of making and administering such vaccines
KR101500771B1 (ko) 2007-03-23 2015-03-18 와이어쓰 엘엘씨 스트렙토코커스 뉴모니아 협막 다당류를 제조하기 위한 단축 정제 방법
AU2008265767B2 (en) 2007-06-20 2014-11-13 Pfizer Ireland Pharmaceuticals Modified polysaccharides for conjugate vaccines
DK2167121T3 (en) 2007-06-26 2015-11-23 Glaxosmithkline Biolog Sa A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
WO2009094730A1 (en) 2008-02-01 2009-08-06 Newcastle Innovation Limited Vaccine compositions
EP2108656A1 (en) 2008-03-19 2009-10-14 Beninati, Concetta Antigenic protein fragments of streptococcus pneumoniae
KR101593770B1 (ko) 2008-12-18 2016-02-15 와이어쓰 엘엘씨 스트렙토코커스 뉴모니에 혈청형 19ａ 폴리사카라이드 분자량을 조절하는 방법
ES2552153T3 (es) 2009-04-30 2015-11-26 Coley Pharmaceutical Group, Inc. Vacuna neumocócica y usos de la misma
WO2010141312A2 (en) 2009-06-01 2010-12-09 Wake Forest University Health Sciences Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same
BR112012005349A2 (pt) 2009-09-09 2016-03-29 Matrivax Res & Dev Corp composição imunogênica, seu método de fabricação, método de fabricação de uma composição de vacina de matriz de proteína, e uso
TW201136603A (en) 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
PL3170508T3 (pl) 2010-06-04 2020-04-30 Wyeth Llc Preparaty szczepionek
CA2835628C (en) 2011-05-11 2023-01-03 Children's Medical Center Corporation Multiple antigen presenting immunogenic composition, and methods and uses thereof
EP2717919B1 (en) 2011-06-03 2016-08-03 3M Innovative Properties Company Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
US9777076B2 (en) 2012-07-16 2017-10-03 Pfizer Inc. Saccharides and uses thereof
SG11201500566XA (en) 2012-08-16 2015-04-29 Pfizer Glycoconjugation processes and compositions
CN103656631B (zh) * 2012-09-24 2015-08-19 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法
GB201218660D0 (en) * 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
PL2935299T3 (pl) 2012-12-20 2020-05-18 Pfizer Inc. Sposób glikokoniugacji
ITMI20130142A1 (it) 2013-01-31 2014-08-01 Biosynth Srl Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati
US20150079132A1 (en) 2013-09-17 2015-03-19 Path Evoking protection against streptotoccus pneumoniae incorporating b-cell and t-cell pneumococcal protein antigens and pneumococcal polysaccharides delivered concomitantly
CN112336854B (zh) 2014-01-21 2024-11-26 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
CN120718167A (zh) 2014-01-21 2025-09-30 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
CN110859957B (zh) 2014-01-21 2024-04-12 辉瑞公司 包含缀合荚膜糖抗原的免疫原性组合物及其用途
EP3443983B1 (en) 2014-02-14 2022-07-20 Pfizer Inc. Immunogenic glycoprotein conjugates
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CN104069504B (zh) 2014-05-11 2019-09-24 江苏康泰生物医学技术有限公司 一种增强多糖蛋白结合物免疫原性的方法
US20150344530A1 (en) 2014-05-29 2015-12-03 Subhash V. Kapre Synthetic Peptides as Carriers for Conjugation with Polysaccharides
SG11201702451WA (en) 2014-10-09 2017-04-27 Msd Wellcome Trust Hilleman Lab Pvt Ltd An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof
HUE053272T2 (hu) 2015-06-23 2021-06-28 Biological E Ltd Multivalens konjugált pneumococcus vakcina
KR20210027523A (ko) 2015-07-21 2021-03-10 화이자 인코포레이티드 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도
JP6884145B2 (ja) 2015-11-20 2021-06-09 ファイザー・インク 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物
CN118356485A (zh) 2017-06-10 2024-07-19 创赏公司 提供改善的免疫原性和亲合力的具有二价或多价缀合物多糖的多价缀合物疫苗

Also Published As

Publication number Publication date
MX2023009362A (es) 2023-08-16
CN118356485A (zh) 2024-07-19
MY198400A (en) 2023-08-28
JP7132954B2 (ja) 2022-09-07
JP2020523323A (ja) 2020-08-06
CN111132691A (zh) 2020-05-08
EP3634481A1 (en) 2020-04-15
KR20240018697A (ko) 2024-02-13
BR112019026192B1 (pt) 2022-05-10
AU2018280272A1 (en) 2020-01-30
KR20200014921A (ko) 2020-02-11
ZA201908528B (en) 2020-09-30
CA3066911C (en) 2022-05-24
AU2018280272C1 (en) 2021-05-06
WO2018227177A1 (en) 2018-12-13
US10688170B2 (en) 2020-06-23
BR112019026192A2 (pt) 2020-06-30
EP3634481A4 (en) 2021-07-21
CA3066911A1 (en) 2018-12-13
KR20240018698A (ko) 2024-02-13
AU2018280272B2 (en) 2021-01-28
KR102634811B1 (ko) 2024-02-06
US20180353591A1 (en) 2018-12-13

Similar Documents

Publication Publication Date Title
MX2019014829A (es) Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas.
MX2022014850A (es) Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora.
MX394768B (es) Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina.
BR112020004502A8 (pt) Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora
MX2020002555A (es) Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora.
CL2020001478A1 (es) Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y métodos de uso de estos.
AR116043A2 (es) Composición de vacuna conjugada de polisacárido-proteína neumocócica 15-valente
CU24660B1 (es) Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197
HRP20231504T1 (hr) Polisaharidi kapsule iz bakterije streptococcus pneumoniae i njihovi konjugati
RU2015131033A (ru) Вакцины с повышенной плотностью размещения углеводного антигена и новый сапониновый адъювант
AR067995A1 (es) Acoplamiento en sitio especifico de farmacos u otros agentes a anticuerpos disenados con extensiones c-terminales
AR084158A1 (es) Formulaciones que mitigan la agregacion inducida por agitacion de composiciones inmunogenicas
BR112015013560A2 (pt) composição imunogênica multivalente; e composição farmacêutica para induzir uma resposta imunológica aos conjugados de polissacarídeo capsular de streptococcus pneumoniae
BR112015004593A2 (pt) composições imunogênicas
BR112015013513A2 (pt) composição imunogênica multivalente; e composição farmacêutica para induzir uma resposta imunológica aos conjugados de polissacarídeo capsular de streptococcus pneumoniae
MX2011009359A (es) Conjugados hapteno-portador con toxinas bacterianas que tienen un peptido señal como portador, y su uso en composiciones inmunogenas.
ZA202103560B (en) Multivalent pneumococcal polysaccharide-protein conjugate vaccine
EA202090319A1 (ru) Пептидные конъюгаты, способ конъюгации и их использование
PH12018501205A1 (en) Synthetic vaccines against streptococcus pneumoniae serotype 2
TH171459A (th) องค์ประกอบมัลติวาเลนท์ นิวโมคอกคัสโพลีแซคคาไรด์-โปรตีน คอนจูเกต
HK1166000A (en) Hapten-carrier conjugates with bacterial toxins having a signal peptide as carrier and their use in immunogenic compositions
HK1185620A (en) Carbohydrate hapten-based anti-cancer vaccines and antibody drugs
TH159844A (th) วัคซีนของวัคซีนของไมโคพลาสมา ไฮโอพนิวโมนิเอ (mycoplasma hyopneumoniae)
WO2007087758A3 (es) Mimotopos de polisacáridos capsulares de neisseria meningitidis y formulaciones farmacéuticas
CU20110202A7 (es) Composición inmunogénica de polisacáridos planos adyuvados y las formulaciones resultantes