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MX2019014875A - Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica. - Google Patents

Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.

Info

Publication number
MX2019014875A
MX2019014875A MX2019014875A MX2019014875A MX2019014875A MX 2019014875 A MX2019014875 A MX 2019014875A MX 2019014875 A MX2019014875 A MX 2019014875A MX 2019014875 A MX2019014875 A MX 2019014875A MX 2019014875 A MX2019014875 A MX 2019014875A
Authority
MX
Mexico
Prior art keywords
rasopathies
compounds
inflammatory diseases
fibrotic disease
cancers
Prior art date
Application number
MX2019014875A
Other languages
English (en)
Inventor
Yaron R Hadari
Luca Carta
Michael Schmertzler
Theresa M Williams
Charles H Reynolds
Rebecca Hutcheson
Original Assignee
SHY Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHY Therapeutics LLC filed Critical SHY Therapeutics LLC
Publication of MX2019014875A publication Critical patent/MX2019014875A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

En la presente memoria se proporcionan métodos y composiciones para tratar cánceres, enfermedades inflamatorias, rasopatías y enfermedad fibrótica que implican la señalización aberrante de Ia superfamilia Ras a través de la unión de compuestos al dominio de unión a GTP de proteínas de Ia superfamilia Ras que incluyen, en ciertos casos, K-Ras y mutantes de esta, y un nuevo método para someter a ensayo dichas composiciones.
MX2019014875A 2017-06-21 2018-06-20 Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica. MX2019014875A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523114P 2017-06-21 2017-06-21
PCT/US2018/038613 WO2018237084A1 (en) 2017-06-21 2018-06-20 COMPOUNDS INTERACTING WITH RAS SUPERFAMIL FOR USE IN THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES AND FIBROTIC DISEASES

Publications (1)

Publication Number Publication Date
MX2019014875A true MX2019014875A (es) 2021-01-29

Family

ID=62904595

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019014875A MX2019014875A (es) 2017-06-21 2018-06-20 Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
MX2022010224A MX2022010224A (es) 2017-06-21 2019-12-10 Compuestos que interactuan con la superfamilia ras para el tratamiento de canceres, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
MX2022010225A MX2022010225A (es) 2017-06-21 2019-12-10 Compuestos que interactuan con la superfamilia ras para el tratamiento de canceres, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022010224A MX2022010224A (es) 2017-06-21 2019-12-10 Compuestos que interactuan con la superfamilia ras para el tratamiento de canceres, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
MX2022010225A MX2022010225A (es) 2017-06-21 2019-12-10 Compuestos que interactuan con la superfamilia ras para el tratamiento de canceres, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.

Country Status (14)

Country Link
US (9) US10588894B2 (es)
EP (2) EP3642209B1 (es)
JP (3) JP7514005B2 (es)
KR (1) KR102736865B1 (es)
CN (1) CN111032662B (es)
AU (2) AU2018288841B2 (es)
BR (1) BR112019027640A2 (es)
CA (1) CA3066939A1 (es)
EA (1) EA201992780A1 (es)
IL (2) IL271230B2 (es)
MA (1) MA49458A (es)
MX (3) MX2019014875A (es)
SG (1) SG11201911929XA (es)
WO (1) WO2018237084A1 (es)

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