MX2019014674A - Virus recombinante de sarampion que expresa proteinas de virus zika y sus aplicaciones. - Google Patents
Virus recombinante de sarampion que expresa proteinas de virus zika y sus aplicaciones.Info
- Publication number
- MX2019014674A MX2019014674A MX2019014674A MX2019014674A MX2019014674A MX 2019014674 A MX2019014674 A MX 2019014674A MX 2019014674 A MX2019014674 A MX 2019014674A MX 2019014674 A MX2019014674 A MX 2019014674A MX 2019014674 A MX2019014674 A MX 2019014674A
- Authority
- MX
- Mexico
- Prior art keywords
- zikv
- virus
- present
- proteins
- recombinant
- Prior art date
Links
- 241000907316 Zika virus Species 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 241000712079 Measles morbillivirus Species 0.000 title abstract 4
- 208000015181 infectious disease Diseases 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 4
- 230000002458 infectious effect Effects 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 101710204837 Envelope small membrane protein Proteins 0.000 abstract 1
- 101710145006 Lysis protein Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 208000001455 Zika Virus Infection Diseases 0.000 abstract 1
- 208000020329 Zika virus infectious disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18421—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18423—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
- G01N2333/12—Mumps virus; Measles virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a proteínas de virus Zika que expresan el virus recombinante de sarampión y sus aplicaciones, en particular en inducir protección preventiva contra el virus Zika. La presente invención se dirige a virus recombinante de sarampión (MV) que expresa al menos (i) el precursor de la proteína de membrana (prM) de un virus Zika (ZIKV), y la proteína de envoltura (E) de un ZIKV o una versión truncada del mismo, o (ii) la proteína E de un ZIKV o una versión truncada del mismo, y se refiere a partículas infecciosas recombinantes del MV-ZIKV capaz de replicarse en un hospedero después de una administración, y también Partículas Similares a Virus (VLP) que contienen estas proteínas ZIKV en su superficie. La presente invención proporciona medios, en particular ácidos nucleicos, vectores, células y sistemas de rescate para producir estas partículas infecciosas recombinantes y VLPs. La presente invención también se refiere al uso de estas partículas infecciosas recombinantes y/o VLP, en particular bajo la forma de una composición, de manera más particular en una formulación de vacuna, para la prevención de una infección por ZIKV o para la protección preventiva contra resultados clínicos de la infección por ZIKV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305676.3A EP3412307A1 (en) | 2017-06-07 | 2017-06-07 | Recombinant measles virus expressing zika virus proteins and their applications |
| PCT/EP2018/064943 WO2018224573A1 (en) | 2017-06-07 | 2018-06-06 | Recombinant measles virus expressing zika virus proteins and their applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019014674A true MX2019014674A (es) | 2020-09-07 |
Family
ID=59276634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019014674A MX2019014674A (es) | 2017-06-07 | 2018-06-06 | Virus recombinante de sarampion que expresa proteinas de virus zika y sus aplicaciones. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11857616B2 (es) |
| EP (2) | EP3412307A1 (es) |
| JP (2) | JP2020524496A (es) |
| CN (1) | CN110891600B (es) |
| AU (1) | AU2018281889B2 (es) |
| BR (1) | BR112019025310A2 (es) |
| CA (1) | CA3064322A1 (es) |
| MX (1) | MX2019014674A (es) |
| WO (1) | WO2018224573A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3031923A1 (en) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| CA3015792A1 (en) * | 2016-02-25 | 2017-08-31 | The Trustees Of The University Of Pennsylvania | Novel vaccines against zika virus |
| EP3412307A1 (en) * | 2017-06-07 | 2018-12-12 | Institut Pasteur | Recombinant measles virus expressing zika virus proteins and their applications |
| KR101966841B1 (ko) * | 2018-12-12 | 2019-04-08 | 대한민국 | 지카바이러스 e 단백질 유래의 재조합 항원 및 이의 용도 |
| US20220168412A1 (en) * | 2019-04-10 | 2022-06-02 | Katholieke Universiteit Leuven | Chimeric Zika-Japanese Encephalitis Virus |
| CN113999823B (zh) * | 2021-12-30 | 2022-04-26 | 北京赛尔富森生物科技有限公司 | D8基因型嵌合麻疹病毒减毒株和制备方法及用途 |
| EP4482862A1 (en) * | 2022-02-22 | 2025-01-01 | Vyro Bio Inc. | Nucleic acid compositions for delivering exogenous polynucleotides and methods of use |
| AU2023362558A1 (en) * | 2022-10-21 | 2025-05-08 | Theravectys | Polynucleotides and lentiviral vectors expressing non-structural antigens of a flavivirus selected from the group of denv, zikv and yfv, inducing protective cd8+ t-cell immunity in a host |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1375512E (pt) | 2002-06-20 | 2009-09-23 | Pasteur Institut | Adnc infeccioso de uma estirpe de vacina aprovada do vírus do sarampo. utilização de composições imunogénicas |
| EP1939214B1 (en) | 2006-12-22 | 2013-07-10 | Institut Pasteur | Cells and methodology to generate non-segmented negative-strand RNA viruses |
| EP2712871A1 (en) * | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
| CN107849558A (zh) * | 2015-06-12 | 2018-03-27 | 国立大学法人三重大学 | 2型人副流感病毒载体和疫苗 |
| WO2016210127A1 (en) * | 2015-06-25 | 2016-12-29 | Technovax, Inc. | Flavivirus and alphavirus virus-like particles (vlps) |
| EP3184119A1 (en) * | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
| EP3412307A1 (en) * | 2017-06-07 | 2018-12-12 | Institut Pasteur | Recombinant measles virus expressing zika virus proteins and their applications |
-
2017
- 2017-06-07 EP EP17305676.3A patent/EP3412307A1/en not_active Withdrawn
-
2018
- 2018-06-06 US US16/618,823 patent/US11857616B2/en active Active
- 2018-06-06 MX MX2019014674A patent/MX2019014674A/es unknown
- 2018-06-06 EP EP18731021.4A patent/EP3634482A1/en not_active Withdrawn
- 2018-06-06 CA CA3064322A patent/CA3064322A1/en active Pending
- 2018-06-06 AU AU2018281889A patent/AU2018281889B2/en not_active Ceased
- 2018-06-06 CN CN201880047044.6A patent/CN110891600B/zh active Active
- 2018-06-06 WO PCT/EP2018/064943 patent/WO2018224573A1/en not_active Ceased
- 2018-06-06 JP JP2019567572A patent/JP2020524496A/ja not_active Ceased
- 2018-06-06 BR BR112019025310-6A patent/BR112019025310A2/pt not_active IP Right Cessation
-
2023
- 2023-05-16 JP JP2023081004A patent/JP2023107780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3064322A1 (en) | 2018-12-13 |
| EP3412307A1 (en) | 2018-12-12 |
| CN110891600B (zh) | 2024-04-02 |
| AU2018281889B2 (en) | 2022-03-03 |
| WO2018224573A8 (en) | 2019-07-25 |
| US20200237893A1 (en) | 2020-07-30 |
| JP2020524496A (ja) | 2020-08-20 |
| EP3634482A1 (en) | 2020-04-15 |
| US11857616B2 (en) | 2024-01-02 |
| BR112019025310A2 (pt) | 2020-06-23 |
| WO2018224573A1 (en) | 2018-12-13 |
| AU2018281889A1 (en) | 2019-12-19 |
| JP2023107780A (ja) | 2023-08-03 |
| CN110891600A (zh) | 2020-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019014674A (es) | Virus recombinante de sarampion que expresa proteinas de virus zika y sus aplicaciones. | |
| PH12015500499A1 (en) | Recombinant measles virus expressing chikungunya virus polypeptides and their applications | |
| PH12020500569A1 (en) | Influenza virus vaccines and uses thereof | |
| EP1917033A4 (en) | VIRUS LIKE PARTICLES AS PARAMYXOVIRUS VACCINES | |
| ZA202003070B (en) | Lassa vaccine | |
| MX2019000215A (es) | Composiciones inmunogenicas a base de listeria que comprenden antigenos de proteinas del tumor de wilms y metodos para su uso. | |
| MX387396B (es) | Un poliepitope quimerico de virus de dengue compuesto por fragmentos de proteinas no estructurales y su uso en una composicion inmunogenica contra infeccion de virus de dengue. | |
| MX2017003117A (es) | Particula tipo virus de flavivirus. | |
| MX380631B (es) | Vectores de adenovirus canino | |
| CL2012000447A1 (es) | Composición o vacuna que comprende un vector viral de un paramixovirus aviar 8 (apmv-8) recombinante; método para producir dicho vector; y uso para preparar medicamento útil para inducir una respuesta inmunológica. | |
| MY189334A (en) | Lentiviral vector-based japanese encephalitis immunogenic composition | |
| HRP20240163T1 (hr) | Metode i pripravci za izazivanje zaštitnog imuniteta protiv infekcije filovirusom | |
| WO2017214596A8 (en) | Compositions and methods for preventing and treating zika virus infection | |
| PH12020550569A1 (en) | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition | |
| WO2012038832A3 (en) | Generation of replicating chimeric measles virus - retrovirus particles | |
| MX390927B (es) | Partículas semejantes a virus recombinantes que utilizan la proteína gag del virus de inmunodeficiencia bovina. | |
| EP4582440A3 (en) | Il-10-containing vaccines and uses thereof | |
| ZA202309368B (en) | Lentiviral vector, lentiviral particle for treating hepatitis b and its preparation method and application thereof | |
| WO2014151687A3 (en) | Compositions and methods to treat aids | |
| WO2019139648A3 (en) | Dna antibody constructs for use against ebola virus | |
| AR108844A1 (es) | Proteínas de fusión y su aplicación en la preparación de vacunas | |
| MX2025013140A (es) | Composiciones para el uso en el tratamiento del acne | |
| MX2015011064A (es) | Vacuna contra el virus de la leucemia bovina. | |
| MX2024001293A (es) | Polipéptidos inductores de il-10 y sus usos. | |
| WO2020144355A3 (fr) | Peptides immunogènes issus de la nucléoprotéine du virus ebola zaïre |