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MX2019013639A - Derivados de indol n-sustituidos. - Google Patents

Derivados de indol n-sustituidos.

Info

Publication number
MX2019013639A
MX2019013639A MX2019013639A MX2019013639A MX2019013639A MX 2019013639 A MX2019013639 A MX 2019013639A MX 2019013639 A MX2019013639 A MX 2019013639A MX 2019013639 A MX2019013639 A MX 2019013639A MX 2019013639 A MX2019013639 A MX 2019013639A
Authority
MX
Mexico
Prior art keywords
indole derivatives
substituted indole
formula
derivatives
prostaglandin
Prior art date
Application number
MX2019013639A
Other languages
English (en)
Other versions
MX394108B (es
Inventor
Sifferlen Thierry
Fretz Heinz
Lyothier Isabelle
Pothier Julien
Richard-Bildstein Sylvia
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2019013639A publication Critical patent/MX2019013639A/es
Publication of MX394108B publication Critical patent/MX394108B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con derivados de la fórmula (I) (ver Fórmula) en donde R1, y R2 son como se describen en la divulgación, a su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como productos farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de la fórmula (I), y especialmente a su uso como moduladores del receptor EP2 de la prostaglandina 2.
MX2019013639A 2017-05-18 2018-05-17 Derivados de indol n-sustituidos. MX394108B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017062008 2017-05-18
PCT/EP2018/062865 WO2018210995A1 (en) 2017-05-18 2018-05-17 N-substituted indole derivatives

Publications (2)

Publication Number Publication Date
MX2019013639A true MX2019013639A (es) 2020-01-21
MX394108B MX394108B (es) 2025-03-21

Family

ID=62186481

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013639A MX394108B (es) 2017-05-18 2018-05-17 Derivados de indol n-sustituidos.

Country Status (32)

Country Link
US (2) US20200069686A1 (es)
EP (1) EP3625224B1 (es)
JP (1) JP7065117B2 (es)
KR (1) KR102650756B1 (es)
CN (1) CN110621666A (es)
AR (1) AR111806A1 (es)
AU (1) AU2018269667B2 (es)
BR (1) BR112019024114A2 (es)
CA (1) CA3063637A1 (es)
CL (1) CL2019003257A1 (es)
CO (1) CO2019010804A2 (es)
CR (1) CR20190567A (es)
CY (1) CY1124528T1 (es)
DK (1) DK3625224T3 (es)
EA (1) EA039630B1 (es)
ES (1) ES2894124T3 (es)
HR (1) HRP20211532T1 (es)
HU (1) HUE056406T2 (es)
IL (1) IL270616B (es)
LT (1) LT3625224T (es)
MA (1) MA49127B1 (es)
MX (1) MX394108B (es)
PE (1) PE20191787A1 (es)
PH (1) PH12019502562B1 (es)
PL (1) PL3625224T3 (es)
PT (1) PT3625224T (es)
RS (1) RS62441B1 (es)
SG (1) SG11201908660RA (es)
SI (1) SI3625224T1 (es)
TW (1) TWI768043B (es)
UA (1) UA124748C2 (es)
WO (1) WO2018210995A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018210988A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as pge2 receptor modulators
MA49126B1 (fr) 2017-05-18 2021-10-29 Idorsia Pharmaceuticals Ltd Dérivés de phényle utilisés en tant que modulateurs des récepteurs des pge2
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
WO2021060281A1 (ja) * 2019-09-24 2021-04-01 Ａｇｃ株式会社 プロスタグランジンｅ２レセプターｅｐ２／ｅｐ４デュアルアンタゴニスト
WO2021205367A1 (en) * 2020-04-08 2021-10-14 Askat Inc. Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia
TW202228674A (zh) 2020-11-13 2022-08-01 日商小野藥品工業股份有限公司 藉由併用ｅｐ４拮抗藥與免疫檢查點抑制物質而進行之癌症治療
WO2025229177A1 (en) 2024-05-02 2025-11-06 Idorsia Pharmaceuticals Ltd Crystalline forms of an n-substituted indole derivative

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Also Published As

Publication number Publication date
US20230165859A1 (en) 2023-06-01
PH12019502562B1 (en) 2024-06-14
RS62441B1 (sr) 2021-11-30
SI3625224T1 (sl) 2021-11-30
PT3625224T (pt) 2021-10-06
KR102650756B1 (ko) 2024-03-22
TW201900637A (zh) 2019-01-01
IL270616B (en) 2022-01-01
AR111806A1 (es) 2019-08-21
AU2018269667B2 (en) 2022-02-03
SG11201908660RA (en) 2019-10-30
UA124748C2 (uk) 2021-11-10
EP3625224A1 (en) 2020-03-25
MA49127B1 (fr) 2022-05-31
CA3063637A1 (en) 2018-11-22
AU2018269667A1 (en) 2019-10-24
LT3625224T (lt) 2021-10-25
WO2018210995A1 (en) 2018-11-22
PH12019502562A1 (en) 2020-07-20
DK3625224T3 (da) 2021-11-08
EA039630B1 (ru) 2022-02-18
CL2019003257A1 (es) 2020-03-27
MA49127A (fr) 2021-05-26
JP2020520359A (ja) 2020-07-09
CR20190567A (es) 2020-02-10
EA201992679A1 (ru) 2020-05-06
CO2019010804A2 (es) 2019-10-09
CN110621666A (zh) 2019-12-27
KR20200006589A (ko) 2020-01-20
MX394108B (es) 2025-03-21
ES2894124T3 (es) 2022-02-11
EP3625224B1 (en) 2021-08-04
JP7065117B2 (ja) 2022-05-11
US20200069686A1 (en) 2020-03-05
BR112019024114A2 (pt) 2020-06-02
CY1124528T1 (el) 2022-07-22
PL3625224T3 (pl) 2022-01-10
HRP20211532T1 (hr) 2022-01-07
PE20191787A1 (es) 2019-12-24
HUE056406T2 (hu) 2022-02-28
TWI768043B (zh) 2022-06-21

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