[go: up one dir, main page]

MX2019013560A - Formulaciones con oxidacion reducida. - Google Patents

Formulaciones con oxidacion reducida.

Info

Publication number
MX2019013560A
MX2019013560A MX2019013560A MX2019013560A MX2019013560A MX 2019013560 A MX2019013560 A MX 2019013560A MX 2019013560 A MX2019013560 A MX 2019013560A MX 2019013560 A MX2019013560 A MX 2019013560A MX 2019013560 A MX2019013560 A MX 2019013560A
Authority
MX
Mexico
Prior art keywords
formulations
protein
methods
oxidation
reduced oxidation
Prior art date
Application number
MX2019013560A
Other languages
English (en)
Inventor
Alavattam Sreedhara
Mallaney Mary
Grewal Parbir
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2019013560A publication Critical patent/MX2019013560A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)

Abstract

La invención proporciona formulaciones que comprenden una proteína en combinación con un compuesto que impide la oxidación de la proteína. La invención también proporciona métodos para elaborar estas formulaciones y métodos para usar estas formulaciones. La invención proporciona además métodos para examinar compuestos para impedir la oxidación de una proteína en una composición de proteína y métodos para prevenir la oxidación de una proteína en una formulación.
MX2019013560A 2013-03-13 2015-09-02 Formulaciones con oxidacion reducida. MX2019013560A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US201361909813P 2013-11-27 2013-11-27

Publications (1)

Publication Number Publication Date
MX2019013560A true MX2019013560A (es) 2020-01-20

Family

ID=51625442

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015011432A MX369671B (es) 2013-03-13 2014-03-13 Formulaciones con oxidacion reducida.
MX2019013560A MX2019013560A (es) 2013-03-13 2015-09-02 Formulaciones con oxidacion reducida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015011432A MX369671B (es) 2013-03-13 2014-03-13 Formulaciones con oxidacion reducida.

Country Status (23)

Country Link
EP (1) EP2968466B1 (es)
JP (3) JP6389236B2 (es)
KR (1) KR102237885B1 (es)
CN (2) CN104968362B (es)
AU (3) AU2014243700B2 (es)
CA (2) CA3113172A1 (es)
DK (1) DK2968466T3 (es)
ES (1) ES2688895T3 (es)
HR (1) HRP20181504T1 (es)
HU (1) HUE039948T2 (es)
IL (2) IL269947B (es)
LT (1) LT2968466T (es)
MX (2) MX369671B (es)
MY (2) MY174679A (es)
NZ (1) NZ711566A (es)
PL (1) PL2968466T3 (es)
PT (1) PT2968466T (es)
RS (1) RS57813B1 (es)
RU (1) RU2707092C2 (es)
SG (2) SG10201705525VA (es)
SI (1) SI2968466T1 (es)
WO (1) WO2014160495A1 (es)
ZA (2) ZA201506876B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
HRP20201161T1 (hr) * 2013-03-13 2020-11-13 F. Hoffmann - La Roche Ag Formulacije sa smanjenom oksidacijom
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
ES2874640T3 (es) 2016-06-27 2021-11-05 Morphosys Ag Formulaciones de anticuerpos anti-CD19
CN111194233A (zh) * 2017-10-13 2020-05-22 株式会社田村特科 有害物质处理方法及臭氧产生装置
AU2019319822A1 (en) * 2018-08-08 2021-03-18 Genentech, Inc. Use of tryptophan derivatives and L-methionine for protein formulation

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
WO1990003430A1 (en) 1988-09-23 1990-04-05 Cetus Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE139258T1 (de) 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP0586505A1 (en) 1991-05-14 1994-03-16 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
EP1514934B1 (en) 1992-02-06 2008-12-31 Novartis Vaccines and Diagnostics, Inc. Biosynthetic binding protein for cancer marker
WO1994004690A1 (en) 1992-08-17 1994-03-03 Genentech, Inc. Bispecific immunoadhesins
PL174494B1 (pl) 1992-11-13 1998-08-31 Idec Pharma Corp Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69726285T2 (de) 1996-08-30 2004-09-09 Upfront Chromatography A/S, Kopenhagen Isolierung von immunglobulinen
JP4215172B2 (ja) 1996-12-03 2009-01-28 アムジェン フレモント インク． 複数のＶ▲下Ｈ▼およびＶ▲下κ▼領域を含むヒトＩｇ遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
US20080318254A9 (en) 1997-03-10 2008-12-25 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
EP1034298B1 (en) 1997-12-05 2011-11-02 The Scripps Research Institute Humanization of murine antibody
JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
DK1167537T3 (da) 1999-03-30 2008-11-10 Japan Tobacco Inc Fremgangsmåde til fremstilling af et monoklonalt antistof
JP2003512821A (ja) 1999-10-04 2003-04-08 メディカゴ インコーポレイテッド 外来性遺伝子の転写調節方法
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
EP1260230A4 (en) * 2000-02-29 2008-08-06 Chugai Pharmaceutical Co Ltd LONG-TERM STABILIZED PREPARATIONS
CA2422586A1 (en) * 2000-09-15 2002-03-21 The Scripps Research Institute Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
US6933123B2 (en) * 2001-04-05 2005-08-23 Yao Xiong Hu Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
EP1463522A4 (en) 2001-05-16 2005-04-13 Einstein Coll Med HUMAN ANTIPNEUMOKOKKEN ANTIBODIES OF NON-THUMBAN ANIMALS
EA014802B1 (ru) 2001-08-23 2011-02-28 Генмаб А/С АНТИТЕЛА К ИНТЕРЛЕЙКИНУ 15 (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ, ИММУНОКОНЪЮГАТ НА ИХ ОСНОВЕ, ГИБРИДОМА, ТРАНСФЕКТОМА, ТРАНСГЕННОЕ ЖИВОТНОЕ, ЭКСПРЕССИОННЫЙ ВЕКТОР (ВАРИАНТЫ) И НУКЛЕИНОВАЯ КИСЛОТА ДЛЯ ИХ ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ (ВАРИАНТЫ) И СПОСОБ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ, ОПОСРЕДОВАННЫХ ИЛ-15, СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОДУКЦИИ TNF-α И СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОЛИФЕРАЦИИ КЛЕТОК
WO2003018056A1 (fr) * 2001-08-29 2003-03-06 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
US20060258841A1 (en) 2003-01-17 2006-11-16 Josef Michl Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
AU2004270103B2 (en) 2003-05-21 2012-02-23 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies against Bacillusanthracis protective antigen
CA2549830A1 (en) * 2003-12-18 2006-01-05 The Scripps Research Institute Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells
WO2007095288A2 (en) * 2006-02-13 2007-08-23 Nektar Therapeutics Methionine-containing protein or peptide compositions and methods of making and using
CN101616685B (zh) * 2006-03-06 2013-07-24 阿穆尼克斯运营公司 非结构化重组聚合物和其应用
JP2007319124A (ja) * 2006-06-02 2007-12-13 Nippon Tablet Kk 健康食品
KR101460820B1 (ko) * 2007-01-16 2014-11-11 아이피아이엔티엘, 엘엘씨 대사 증후군의 치료를 위한 신규한 조성물
CA2719658C (en) * 2008-04-01 2019-10-01 Antipodean Pharmaceuticals, Inc. Compositions and methods for skin care
ES2616231T3 (es) * 2008-08-21 2017-06-12 Immunogenics Llc Formulación para administración oral de proteínas
EP2334323A2 (en) * 2008-09-10 2011-06-22 F. Hoffmann-La Roche AG Compositions and methods for the prevention of oxidative degradation of proteins
SI2331090T1 (en) * 2008-09-19 2018-04-30 Pfizer Inc. Stable liquid antibody formulation
CA2802756C (en) * 2010-06-24 2021-05-04 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations
RU2447448C1 (ru) * 2010-08-30 2012-04-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ стабилизации антител в водных растворах
US9700548B2 (en) * 2011-06-09 2017-07-11 Requis Pharmaceuticals Inc. Antihistamines combined with dietary supplements for improved health
WO2013001044A1 (en) * 2011-06-28 2013-01-03 Leukocare Ag Method for preventing the unfolding of a (poly) peptide and/or inducing the (re- ) folding of a (poly) peptide

Also Published As

Publication number Publication date
RU2015143548A (ru) 2017-04-20
PT2968466T (pt) 2018-10-22
AU2021201366A1 (en) 2021-03-18
CN104968362A (zh) 2015-10-07
HRP20181504T1 (hr) 2018-11-02
ZA201906057B (en) 2022-04-28
DK2968466T3 (en) 2018-10-22
EP2968466A1 (en) 2016-01-20
MY199135A (en) 2023-10-17
IL240933B (en) 2019-10-31
JP2018150317A (ja) 2018-09-27
SG10201705525VA (en) 2017-08-30
MX369671B (es) 2019-11-15
LT2968466T (lt) 2018-10-10
JP2020164531A (ja) 2020-10-08
JP6389236B2 (ja) 2018-09-12
CA2904166C (en) 2021-05-18
CA2904166A1 (en) 2014-10-02
CN104968362B (zh) 2018-12-14
RU2707092C2 (ru) 2019-11-22
PL2968466T3 (pl) 2018-11-30
MX2015011432A (es) 2016-04-27
AU2019202464B2 (en) 2020-12-10
HUE039948T2 (hu) 2019-02-28
AU2014243700B2 (en) 2019-01-24
HK1211219A1 (en) 2016-05-20
AU2014243700A1 (en) 2015-10-08
JP2016520521A (ja) 2016-07-14
AU2019202464A1 (en) 2019-05-02
RS57813B1 (sr) 2018-12-31
ES2688895T3 (es) 2018-11-07
CA3113172A1 (en) 2014-10-02
SG11201507043SA (en) 2015-10-29
WO2014160495A1 (en) 2014-10-02
IL269947B (en) 2022-08-01
MY174679A (en) 2020-05-06
IL240933A0 (en) 2015-11-30
EP2968466A4 (en) 2016-10-26
SI2968466T1 (sl) 2018-10-30
BR112015022484A2 (pt) 2017-07-18
IL269947A (es) 2019-12-31
NZ751543A (en) 2020-09-25
CN110075293A (zh) 2019-08-02
ZA201506876B (en) 2019-12-18
KR102237885B1 (ko) 2021-04-07
NZ711566A (en) 2020-06-26
KR20150130397A (ko) 2015-11-23
EP2968466B1 (en) 2018-07-25

Similar Documents

Publication Publication Date Title
MY191169A (en) Anti-fcrh5 antibodies
CL2016002772A1 (es) Composiciones de insulina de rápida acción
IL253976A0 (en) Preparations containing a mixture of allergens and methods of using them
MX2019013560A (es) Formulaciones con oxidacion reducida.
MX2015008999A (es) Inhibidores mk2 y usos de los mismos.
SG10201913040SA (en) Compositions and methods for stabilizing flaviviruses with improved formulations
WO2015038796A3 (en) Secretion of heme-containing polypeptides
PH12014502132A1 (en) Anti-lgr5 antibodies and immunoconjugates
IN2015DN00127A (es)
WO2015120062A3 (en) Therapeutic compounds and compositions
AR095398A1 (es) Formulaciones con oxidación reducida
EP3261437A4 (en) Fungicidal compounds and compositions
PL3411432T3 (pl) Kompozycja wulkanizująca zawierająca cyklododekasiarkę i ulepszony związek cyklododekasiarki
PH12017502028A1 (en) Vortioxetine pyroglutamate
IN2014DN11078A (es)
SG10201900598TA (en) Factor viii formulation
EP3193637A4 (en) Improved drink stabilizer composition and stabilized drink compositions
MX2015011433A (es) Formulaciones con oxidacion reducida.
EP3297440A4 (en) COMPOSITION WITH CARBOPLATIN AND USE
EP3153492A4 (en) Novel compound and fragrance composition containing same
PH12017502148A1 (en) Pharmaceutical compositions and use thereof
GEP20217236B (en) Composition comprising pentose and polyphenolic compound
EP3106160B8 (en) Combination composition comprising huperzine
PL3568203T3 (pl) Związki i kompozycje
GB201614961D0 (en) Compounds and compositions for use