MX2019012765A - Proceso para la fabricacion de la forma alfa de vortioxetina hbr. - Google Patents
Proceso para la fabricacion de la forma alfa de vortioxetina hbr.Info
- Publication number
- MX2019012765A MX2019012765A MX2019012765A MX2019012765A MX2019012765A MX 2019012765 A MX2019012765 A MX 2019012765A MX 2019012765 A MX2019012765 A MX 2019012765A MX 2019012765 A MX2019012765 A MX 2019012765A MX 2019012765 A MX2019012765 A MX 2019012765A
- Authority
- MX
- Mexico
- Prior art keywords
- manufacture
- alpha
- vortioxetine hbr
- vortioxetine
- hbr
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- VNGRUFUIHGGOOM-UHFFFAOYSA-N vortioxetine hydrobromide Chemical compound Br.CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 VNGRUFUIHGGOOM-UHFFFAOYSA-N 0.000 title abstract 2
- OJYGBLRPYBAHRT-UHFFFAOYSA-N alphachloralose Chemical compound O1C(C(Cl)(Cl)Cl)OC2C(O)C(C(O)CO)OC21 OJYGBLRPYBAHRT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Abstract
Se proporciona un proceso para la fabricación de la forma a de vortioxetina HBr.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201700264 | 2017-04-25 | ||
| PCT/EP2018/060192 WO2018197360A1 (en) | 2017-04-25 | 2018-04-20 | Process for the manufacture of vortioxetine hbr alpha-form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019012765A true MX2019012765A (es) | 2019-12-05 |
Family
ID=62111030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019012765A MX2019012765A (es) | 2017-04-25 | 2018-04-20 | Proceso para la fabricacion de la forma alfa de vortioxetina hbr. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11124491B2 (es) |
| EP (1) | EP3615518B1 (es) |
| JP (1) | JP7121751B2 (es) |
| KR (1) | KR102551433B1 (es) |
| CN (1) | CN110520415A (es) |
| AU (1) | AU2018258947C1 (es) |
| BR (1) | BR112018076411A2 (es) |
| CL (1) | CL2019003024A1 (es) |
| CO (1) | CO2019011592A2 (es) |
| CY (1) | CY1124974T1 (es) |
| DK (1) | DK3615518T3 (es) |
| ES (1) | ES2905962T3 (es) |
| HR (1) | HRP20220108T1 (es) |
| HU (1) | HUE057993T2 (es) |
| IL (1) | IL270052B2 (es) |
| LT (1) | LT3615518T (es) |
| MA (1) | MA49056A (es) |
| MX (1) | MX2019012765A (es) |
| PL (1) | PL3615518T3 (es) |
| PT (1) | PT3615518T (es) |
| RS (1) | RS62823B1 (es) |
| SG (1) | SG11201909678PA (es) |
| SI (1) | SI3615518T1 (es) |
| SM (1) | SMT202200073T1 (es) |
| WO (1) | WO2018197360A1 (es) |
| ZA (1) | ZA201906829B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019155352A1 (en) * | 2018-02-06 | 2019-08-15 | Piramal Enterprises Limited | An improved process for the preparation of vortioxetine and salts thereof |
| CN112125868B (zh) * | 2020-09-25 | 2021-08-03 | 中山万远新药研发有限公司 | 一种氢溴酸伏硫西汀晶型及其制备方法、组合物与用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| AU2007260355B2 (en) | 2006-06-16 | 2013-08-15 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment |
| TW200848411A (en) | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
| TW201033181A (en) | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
| BR112015006075B1 (pt) | 2012-09-19 | 2022-10-04 | Sandoz Ag | Composto cristalino, composição farmacêutica, uso do composto cristalino, hidrato cristalino do bromidrato de vortioxetina, método para a preparação do hidrato cristalino de bromidrato de vortioxetina, método para a preparação do composto cristalino e uso do hidrato cristalino de bromidrato de vortioxetina |
| EP3099669A1 (en) * | 2014-01-31 | 2016-12-07 | Egis Gyógyszergyár Zrt. | Process for the preparation of vortioxetine salts |
| US9687484B2 (en) | 2014-07-18 | 2017-06-27 | Dipharma Francis S.R.L. | Crystalline forms of an antidepressant compound |
| CN105367515B (zh) | 2015-05-08 | 2017-10-27 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀α晶型的制备方法 |
| CN104910099B (zh) | 2015-05-22 | 2017-03-08 | 扬子江药业集团有限公司 | 一种氢溴酸沃替西汀晶体的制备方法 |
| CN106316986B (zh) | 2015-07-03 | 2019-02-05 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪氢溴酸盐α型晶体的制备方法 |
-
2018
- 2018-04-20 BR BR112018076411-6A patent/BR112018076411A2/pt active Search and Examination
- 2018-04-20 RS RS20220047A patent/RS62823B1/sr unknown
- 2018-04-20 DK DK18721975.3T patent/DK3615518T3/da active
- 2018-04-20 CN CN201880025179.2A patent/CN110520415A/zh active Pending
- 2018-04-20 LT LTEPPCT/EP2018/060192T patent/LT3615518T/lt unknown
- 2018-04-20 SG SG11201909678P patent/SG11201909678PA/en unknown
- 2018-04-20 SM SM20220073T patent/SMT202200073T1/it unknown
- 2018-04-20 AU AU2018258947A patent/AU2018258947C1/en active Active
- 2018-04-20 HR HRP20220108TT patent/HRP20220108T1/hr unknown
- 2018-04-20 IL IL270052A patent/IL270052B2/en unknown
- 2018-04-20 US US16/604,313 patent/US11124491B2/en active Active
- 2018-04-20 MA MA049056A patent/MA49056A/fr unknown
- 2018-04-20 JP JP2019557745A patent/JP7121751B2/ja active Active
- 2018-04-20 ES ES18721975T patent/ES2905962T3/es active Active
- 2018-04-20 PL PL18721975T patent/PL3615518T3/pl unknown
- 2018-04-20 SI SI201830537T patent/SI3615518T1/sl unknown
- 2018-04-20 WO PCT/EP2018/060192 patent/WO2018197360A1/en not_active Ceased
- 2018-04-20 KR KR1020197031292A patent/KR102551433B1/ko active Active
- 2018-04-20 HU HUE18721975A patent/HUE057993T2/hu unknown
- 2018-04-20 EP EP18721975.3A patent/EP3615518B1/en active Active
- 2018-04-20 PT PT187219753T patent/PT3615518T/pt unknown
- 2018-04-20 MX MX2019012765A patent/MX2019012765A/es unknown
-
2019
- 2019-10-16 ZA ZA2019/06829A patent/ZA201906829B/en unknown
- 2019-10-18 CO CO2019011592A patent/CO2019011592A2/es unknown
- 2019-10-22 CL CL2019003024A patent/CL2019003024A1/es unknown
-
2022
- 2022-02-08 CY CY20221100108T patent/CY1124974T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021010418A (es) | Composiciones que comprenden una caseína y métodos para producir las mismas. | |
| AU2014375265A1 (en) | Novel pyrazolyl-heteroarylamides as pesticides | |
| HUE064642T2 (hu) | Eljárás ozanimod elõállítására | |
| ZA201902125B (en) | Process for the production of 2-alkylalkanol | |
| LT3713872T (lt) | Fosfogipso skaidymo būdas | |
| MX2017008280A (es) | Proceso para elaborar cenicriviroc y analogos relacionados. | |
| EP3110857A4 (en) | Process for the production of modified butyl rubber | |
| EP3532055A4 (en) | COMPOSITIONS AND PROCESSES FOR THE PRODUCTION OF COMPOUNDS | |
| MY187959A (en) | Reactor | |
| SG10201908248PA (en) | Processes for preparing fluoroketolides | |
| MX2019004182A (es) | Proceso para la fabricacion de 2,6-dimetil-5-hepten-1-al. | |
| MX2023009431A (es) | Metodo para crear un compuesto a base de mercurio, compuesto a base de mercurio, metodos de uso del compuesto a base de mercurio y usos del compuesto a base de mercurio. | |
| MX2019012765A (es) | Proceso para la fabricacion de la forma alfa de vortioxetina hbr. | |
| GB201814291D0 (en) | Process for the production of gallium radionculides | |
| MA39877A (fr) | Formes solides d'un composé pharmaceutiquement actif | |
| MX2019002017A (es) | Derivados de sofosbuvir para el tratamiento de la hepatitis c. | |
| MY174200A (en) | Process for reducing the chlorine content of organotetraphosphites | |
| MX2018011529A (es) | Procesos para la preparacion de acidos heteroaril carboxilicos. | |
| MX2019001763A (es) | Metodo para preparar derivados de estireno sustituidos. | |
| MY180413A (en) | Process for the decomposition of lignocellulose-containing biomass-material | |
| MX2019006956A (es) | Proceso para la fabricacion de derivados de diazepina. | |
| MX2020010343A (es) | Proceso para la purificacion de biocomposiciones complejas. | |
| EP3720967A4 (en) | METHOD FOR PRODUCING MALTOSYL ISOMALTOOLIGOSACCHARIDES (MIMO) | |
| PL3415011T3 (pl) | Procedura wytwarzania półskorupek waflowych | |
| EP3555113A4 (en) | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF NOMEGESTROL-ACETATE |