MX2019012251A - Sal agonista del receptor opioide, su forma de cristal i de sal de fumarato y metodo de preparacion de la misma. - Google Patents
Sal agonista del receptor opioide, su forma de cristal i de sal de fumarato y metodo de preparacion de la misma.Info
- Publication number
- MX2019012251A MX2019012251A MX2019012251A MX2019012251A MX2019012251A MX 2019012251 A MX2019012251 A MX 2019012251A MX 2019012251 A MX2019012251 A MX 2019012251A MX 2019012251 A MX2019012251 A MX 2019012251A MX 2019012251 A MX2019012251 A MX 2019012251A
- Authority
- MX
- Mexico
- Prior art keywords
- salt
- preparation
- crystal form
- fumarate
- opioid receptor
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 2
- 102000003840 Opioid Receptors Human genes 0.000 title 1
- 108090000137 Opioid Receptors Proteins 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229940121954 Opioid receptor agonist Drugs 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- -1 deca -9-yl Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000003402 opiate agonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se relaciona con un agonista del receptor opioide la sal de fumarato de (1S,4S)-4- etoxi-N-(2-((R)-9-(piridin-2-il)-6-oxaspiro [4.5]deca-9-il)etil)-1,2,3,4-tetrahidronaftalen-1-amina, su forma de cristal I de la sal de fumarato, y un metodo de preparacion y aplicación del mismo.(ver formula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710242119 | 2017-04-14 | ||
| PCT/CN2018/082935 WO2018188643A1 (zh) | 2017-04-14 | 2018-04-13 | 一种阿片样物质受体(mor)激动剂的盐、其富马酸盐i晶型及制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019012251A true MX2019012251A (es) | 2019-11-28 |
| MX383989B MX383989B (es) | 2025-03-14 |
Family
ID=63792318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019012251A MX383989B (es) | 2017-04-14 | 2018-04-13 | Sal agonista del receptor opioide, su forma de cristal i de sal de fumarato y método de preparación de la misma. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11014914B2 (es) |
| EP (1) | EP3610875B1 (es) |
| JP (1) | JP7153030B6 (es) |
| KR (1) | KR20190140962A (es) |
| CN (1) | CN110049980B (es) |
| AU (1) | AU2018251119B2 (es) |
| BR (1) | BR112019021447A2 (es) |
| CA (1) | CA3057383A1 (es) |
| CY (1) | CY1124063T1 (es) |
| DK (1) | DK3610875T3 (es) |
| ES (1) | ES2828636T3 (es) |
| HR (1) | HRP20210022T1 (es) |
| HU (1) | HUE053244T2 (es) |
| LT (1) | LT3610875T (es) |
| MX (1) | MX383989B (es) |
| MY (1) | MY196571A (es) |
| PL (1) | PL3610875T3 (es) |
| PT (1) | PT3610875T (es) |
| RS (1) | RS61193B1 (es) |
| SI (1) | SI3610875T1 (es) |
| TW (1) | TWI682929B (es) |
| UA (1) | UA124400C2 (es) |
| WO (1) | WO2018188643A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI682929B (zh) * | 2017-04-14 | 2020-01-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種阿片樣物質受體（mor）激動劑的鹽、其富馬酸鹽i晶型及製備方法 |
| JP2020516591A (ja) * | 2017-04-14 | 2020-06-11 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | Ｍｏｒアゴニストおよびｋｏｒアゴニストを含有する医薬組成物、およびその用途 |
| WO2019205983A1 (zh) * | 2018-04-28 | 2019-10-31 | 四川科伦博泰生物医药股份有限公司 | 氧杂螺环类化合物及其制备方法和用途 |
| WO2020073985A1 (zh) * | 2018-10-12 | 2020-04-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法 |
| WO2020073984A1 (zh) * | 2018-10-12 | 2020-04-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法 |
| CN111662284B (zh) * | 2019-03-06 | 2021-08-10 | 上海海雁医药科技有限公司 | 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途 |
| KR20210113824A (ko) | 2020-03-09 | 2021-09-17 | 건국대학교 산학협력단 | 뮤 오피오이드 수용체의 활성화제를 유효성분으로 포함하는 기분 장애의 예방용 조성물 |
| JP7707406B2 (ja) * | 2021-07-13 | 2025-07-14 | 上海海雁医薬科技有限公司 | Ｍｏｒ受容体アゴニストの薬学的に許容できる塩、その多形体及びその使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3290415T3 (pl) | 2011-03-23 | 2021-07-19 | Trevena, Inc. | Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania |
| US10442793B2 (en) | 2015-10-15 | 2019-10-15 | Jiangsu Hengrui Medicine Co., Ltd | Oxa spiro derivative, preparation method therefor, and applications thereof in medicines |
| TWI682929B (zh) * | 2017-04-14 | 2020-01-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種阿片樣物質受體（mor）激動劑的鹽、其富馬酸鹽i晶型及製備方法 |
-
2018
- 2018-04-13 TW TW107112721A patent/TWI682929B/zh not_active IP Right Cessation
- 2018-04-13 AU AU2018251119A patent/AU2018251119B2/en not_active Ceased
- 2018-04-13 WO PCT/CN2018/082935 patent/WO2018188643A1/zh not_active Ceased
- 2018-04-13 KR KR1020197033496A patent/KR20190140962A/ko not_active Abandoned
- 2018-04-13 UA UAA201911049A patent/UA124400C2/uk unknown
- 2018-04-13 PL PL18784878T patent/PL3610875T3/pl unknown
- 2018-04-13 BR BR112019021447A patent/BR112019021447A2/pt not_active IP Right Cessation
- 2018-04-13 PT PT187848783T patent/PT3610875T/pt unknown
- 2018-04-13 RS RS20201514A patent/RS61193B1/sr unknown
- 2018-04-13 HR HRP20210022TT patent/HRP20210022T1/hr unknown
- 2018-04-13 SI SI201830176T patent/SI3610875T1/sl unknown
- 2018-04-13 DK DK18784878.3T patent/DK3610875T3/da active
- 2018-04-13 US US16/499,453 patent/US11014914B2/en not_active Expired - Fee Related
- 2018-04-13 CA CA3057383A patent/CA3057383A1/en active Pending
- 2018-04-13 ES ES18784878T patent/ES2828636T3/es active Active
- 2018-04-13 CN CN201880004976.2A patent/CN110049980B/zh active Active
- 2018-04-13 LT LTEP18784878.3T patent/LT3610875T/lt unknown
- 2018-04-13 HU HUE18784878A patent/HUE053244T2/hu unknown
- 2018-04-13 MX MX2019012251A patent/MX383989B/es unknown
- 2018-04-13 EP EP18784878.3A patent/EP3610875B1/en active Active
- 2018-04-13 JP JP2019555801A patent/JP7153030B6/ja active Active
-
2019
- 2019-10-03 MY MYPI2019005849A patent/MY196571A/en unknown
-
2020
- 2020-10-22 CY CY20201101000T patent/CY1124063T1/el unknown
-
2021
- 2021-01-07 US US17/143,549 patent/US20210130332A1/en not_active Abandoned
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