MX2019010653A - Inhibidores de beta secretasa. - Google Patents
Inhibidores de beta secretasa.Info
- Publication number
- MX2019010653A MX2019010653A MX2019010653A MX2019010653A MX2019010653A MX 2019010653 A MX2019010653 A MX 2019010653A MX 2019010653 A MX2019010653 A MX 2019010653A MX 2019010653 A MX2019010653 A MX 2019010653A MX 2019010653 A MX2019010653 A MX 2019010653A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- dementia
- compounds
- compositions
- secretase
- Prior art date
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a inhibidores tricíclicos de beta-secretasa que tienen la estructura mostrada en las formulas (I) y (II) (ver formula) (I) y (II) donde los radicales son como se definen en la memoria descriptiva; la invencion se dirige tambien a composiciones farmaceuticas que comprenden este tipo de compuestos, a procedimientos para preparar compuestos y composiciones de este tipo y al uso de compuestos y composiciones de este tipo para la prevención y el tratamiento de trastornos en los que esta implicada beta-secretasa tales como la enfermedad de Alzheimer (EA), defecto cognitivo leve, senilidad, demencia, demencia con cuerpos de Lewy, síndrome de Down, demencia asociada a apoplejía, demencia asociada con la enfermedad de Parkinson, demencia asociada con betaamiloide, degeneración macular relacionada con la edad, diabetes tipo 2 y otros trastornos metabólicos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762468070P | 2017-03-07 | 2017-03-07 | |
| EP17189778 | 2017-09-07 | ||
| PCT/EP2018/055403 WO2018162445A1 (en) | 2017-03-07 | 2018-03-06 | Inhibitors of beta secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019010653A true MX2019010653A (es) | 2019-10-21 |
Family
ID=61616995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010653A MX2019010653A (es) | 2017-03-07 | 2018-03-06 | Inhibidores de beta secretasa. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20190389882A1 (es) |
| EP (1) | EP3592752A1 (es) |
| JP (1) | JP2020509064A (es) |
| KR (1) | KR20190126346A (es) |
| CN (1) | CN110382506A (es) |
| AU (1) | AU2018229723A1 (es) |
| CA (1) | CA3051779A1 (es) |
| MA (1) | MA47731A (es) |
| MX (1) | MX2019010653A (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077277A1 (es) * | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
-
2018
- 2018-03-06 US US16/489,910 patent/US20190389882A1/en not_active Abandoned
- 2018-03-06 MA MA047731A patent/MA47731A/fr unknown
- 2018-03-06 KR KR1020197028606A patent/KR20190126346A/ko not_active Withdrawn
- 2018-03-06 EP EP18710001.1A patent/EP3592752A1/en not_active Withdrawn
- 2018-03-06 AU AU2018229723A patent/AU2018229723A1/en not_active Abandoned
- 2018-03-06 CA CA3051779A patent/CA3051779A1/en not_active Abandoned
- 2018-03-06 CN CN201880016097.1A patent/CN110382506A/zh active Pending
- 2018-03-06 JP JP2019548451A patent/JP2020509064A/ja active Pending
- 2018-03-06 MX MX2019010653A patent/MX2019010653A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110382506A (zh) | 2019-10-25 |
| MA47731A (fr) | 2020-01-15 |
| CA3051779A1 (en) | 2018-09-13 |
| KR20190126346A (ko) | 2019-11-11 |
| US20190389882A1 (en) | 2019-12-26 |
| JP2020509064A (ja) | 2020-03-26 |
| EP3592752A1 (en) | 2020-01-15 |
| AU2018229723A1 (en) | 2019-08-15 |
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