MX2019009733A - 3'-deamino-3'-(2''-pirrolin-1''-il)-5-imino-13-desoxiantraciclina s y metodos de preparacion. - Google Patents
3'-deamino-3'-(2''-pirrolin-1''-il)-5-imino-13-desoxiantraciclina s y metodos de preparacion.Info
- Publication number
- MX2019009733A MX2019009733A MX2019009733A MX2019009733A MX2019009733A MX 2019009733 A MX2019009733 A MX 2019009733A MX 2019009733 A MX2019009733 A MX 2019009733A MX 2019009733 A MX2019009733 A MX 2019009733A MX 2019009733 A MX2019009733 A MX 2019009733A
- Authority
- MX
- Mexico
- Prior art keywords
- deoxyanthracycline
- preparation
- pyrrolino
- deoxyanthracyclines
- deamino
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Derivados de 2-pirrolino-13-desoxiantraciclina, usos médicos de los mismos y un proceso para fabricarlos. Una 2-pirrolino-13-desoxiantraciclina y una 13-desoxiantraciclina pueden administrarse a un paciente de forma simultánea o secuencial en cantidades para producir un efecto terapéutico enérgico con mayor potencia y eficacia, en comparación con la suma de los efectos de cada fármaco cuando se administra solo. También se proporciona una composición o preparación de una 2-pirrolino-13- desoxiantraciclina y una 13-desoxiantraciclina para producir un potente efecto o terapéutico contra el cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/434,617 US10450340B2 (en) | 2017-02-16 | 2017-02-16 | 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation |
| PCT/US2018/000090 WO2018151872A1 (en) | 2017-02-16 | 2018-02-16 | 3'deamino-3'-(2"-pyrroline-1"-yl)-5-imino-13-deoxyanthracyclines and methods of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019009733A true MX2019009733A (es) | 2020-02-07 |
| MX388090B MX388090B (es) | 2025-03-19 |
Family
ID=61692048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019009733A MX388090B (es) | 2017-02-16 | 2018-02-16 | 3'-deamino-3'-(2''-pirrolin-1''-il)-5-imino-13-desoxiantraciclinas y metodos de preparacion. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10450340B2 (es) |
| EP (1) | EP3582788A1 (es) |
| JP (1) | JP7159177B2 (es) |
| KR (1) | KR20190117609A (es) |
| CN (1) | CN110573165B (es) |
| AU (1) | AU2018220520A1 (es) |
| BR (1) | BR112019017166A2 (es) |
| CA (1) | CA3053417A1 (es) |
| IL (1) | IL268680B (es) |
| MX (1) | MX388090B (es) |
| WO (1) | WO2018151872A1 (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| US5948896A (en) | 1997-08-13 | 1999-09-07 | Gem Pharmaceuticals | Processes for preparing 13-deoxy anthracycline derivatives |
| US5942605A (en) | 1998-03-03 | 1999-08-24 | Gem Pharmaceuticals, Inc. | 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them |
| US7244829B2 (en) | 2004-11-08 | 2007-07-17 | Gem Pharmaceuticals, Llc | Compositions and processes for preparing 13-deoxy-anthracyclines |
| JP2007261976A (ja) | 2006-03-28 | 2007-10-11 | Meiji Seika Kaisha Ltd | 抗腫瘍性アンスラサイクリン系抗生物質の製造法 |
| US7776832B2 (en) * | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| US9904704B2 (en) | 2014-04-22 | 2018-02-27 | Openx Software Limited | System and method for controlling audience data and tracking |
-
2017
- 2017-02-16 US US15/434,617 patent/US10450340B2/en active Active
-
2018
- 2018-02-16 BR BR112019017166A patent/BR112019017166A2/pt not_active Application Discontinuation
- 2018-02-16 JP JP2019544029A patent/JP7159177B2/ja active Active
- 2018-02-16 WO PCT/US2018/000090 patent/WO2018151872A1/en not_active Ceased
- 2018-02-16 CA CA3053417A patent/CA3053417A1/en active Pending
- 2018-02-16 KR KR1020197026451A patent/KR20190117609A/ko not_active Abandoned
- 2018-02-16 AU AU2018220520A patent/AU2018220520A1/en not_active Abandoned
- 2018-02-16 EP EP18712287.4A patent/EP3582788A1/en not_active Withdrawn
- 2018-02-16 MX MX2019009733A patent/MX388090B/es unknown
- 2018-02-16 CN CN201880025418.4A patent/CN110573165B/zh active Active
-
2019
- 2019-08-13 IL IL268680A patent/IL268680B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018220520A1 (en) | 2019-09-05 |
| IL268680A (en) | 2019-10-31 |
| WO2018151872A1 (en) | 2018-08-23 |
| JP2020507608A (ja) | 2020-03-12 |
| CN110573165A (zh) | 2019-12-13 |
| US10450340B2 (en) | 2019-10-22 |
| MX388090B (es) | 2025-03-19 |
| CA3053417A1 (en) | 2018-08-23 |
| RU2019128837A (ru) | 2021-03-16 |
| CN110573165B (zh) | 2023-07-11 |
| EP3582788A1 (en) | 2019-12-25 |
| RU2019128837A3 (es) | 2021-06-17 |
| KR20190117609A (ko) | 2019-10-16 |
| IL268680B (en) | 2022-02-01 |
| US20180230175A1 (en) | 2018-08-16 |
| JP7159177B2 (ja) | 2022-10-24 |
| BR112019017166A2 (pt) | 2020-04-14 |
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