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MX2019009351A - Piridinas sustituidas con heteroarilsulfonilo y su uso en el tratamiento del cancer. - Google Patents

Piridinas sustituidas con heteroarilsulfonilo y su uso en el tratamiento del cancer.

Info

Publication number
MX2019009351A
MX2019009351A MX2019009351A MX2019009351A MX2019009351A MX 2019009351 A MX2019009351 A MX 2019009351A MX 2019009351 A MX2019009351 A MX 2019009351A MX 2019009351 A MX2019009351 A MX 2019009351A MX 2019009351 A MX2019009351 A MX 2019009351A
Authority
MX
Mexico
Prior art keywords
cancer
heteroarylsulfonyl
treatment
substituted pyridines
compounds
Prior art date
Application number
MX2019009351A
Other languages
English (en)
Other versions
MX392000B (es
Inventor
Suna Edgars
Pelcman Benjamin
Stafford William
Priede Martins
Original Assignee
Oblique Therapeutics Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oblique Therapeutics Ab filed Critical Oblique Therapeutics Ab
Publication of MX2019009351A publication Critical patent/MX2019009351A/es
Publication of MX392000B publication Critical patent/MX392000B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan compuestos de la Fórmula I (I) (ver formula I) o sales aceptables desde el punto de vista farmacéutico de estos, en donde L, 10 R1, R2, R3 y X tienen significados proporcionados en la descripción, en donde los compuestos son útiles en el tratamiento de tipos de cáncer.
MX2019009351A 2017-02-07 2018-02-07 Piridinas sustituidas con heteroarilsulfonilo y su uso en el tratamiento del cáncer. MX392000B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762455639P 2017-02-07 2017-02-07
US201762594799P 2017-12-05 2017-12-05
PCT/GB2018/050343 WO2018146469A1 (en) 2017-02-07 2018-02-07 Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer

Publications (2)

Publication Number Publication Date
MX2019009351A true MX2019009351A (es) 2019-09-19
MX392000B MX392000B (es) 2025-03-21

Family

ID=61226606

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009351A MX392000B (es) 2017-02-07 2018-02-07 Piridinas sustituidas con heteroarilsulfonilo y su uso en el tratamiento del cáncer.

Country Status (12)

Country Link
US (1) US11028067B2 (es)
EP (1) EP3580215A1 (es)
JP (1) JP2020507625A (es)
KR (1) KR20190115013A (es)
CN (1) CN110382486A (es)
AU (1) AU2018218519B2 (es)
BR (1) BR112019016223A2 (es)
CA (1) CA3051537A1 (es)
MA (1) MA47451A (es)
MX (1) MX392000B (es)
WO (1) WO2018146469A1 (es)
ZA (1) ZA201904967B (es)

Families Citing this family (6)

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GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
CN110382465A (zh) 2017-02-07 2019-10-25 欧比力克治疗公司 亚磺酰基吡啶和其在癌症治疗中的用途
EP3580209A1 (en) 2017-02-07 2019-12-18 Oblique Therapeutics AB Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
CN110382464A (zh) 2017-02-07 2019-10-25 欧比力克治疗公司 烃基磺酰基取代的吡啶和其在癌症治疗中的用途
JP2021513573A (ja) * 2018-02-12 2021-05-27 シンダ ファーマ エービー 癌の処置に使用されるチオレドキシン還元酵素阻害剤
FI3853234T3 (fi) 2018-09-18 2025-07-28 Nikang Therapeutics Inc Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä

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EP3580209A1 (en) 2017-02-07 2019-12-18 Oblique Therapeutics AB Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
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Also Published As

Publication number Publication date
CN110382486A (zh) 2019-10-25
EP3580215A1 (en) 2019-12-18
JP2020507625A (ja) 2020-03-12
AU2018218519A1 (en) 2019-08-15
ZA201904967B (en) 2023-12-20
RU2019128045A (ru) 2021-03-09
US20200223819A1 (en) 2020-07-16
AU2018218519B2 (en) 2021-08-05
KR20190115013A (ko) 2019-10-10
CA3051537A1 (en) 2018-08-16
WO2018146469A1 (en) 2018-08-16
US11028067B2 (en) 2021-06-08
MX392000B (es) 2025-03-21
MA47451A (fr) 2019-12-18
BR112019016223A2 (pt) 2020-04-07
RU2019128045A3 (es) 2021-03-09

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